Accession ID: MIRT000534 [miRNA, hsa-miR-216a-5p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-216aLinkOut: [miRBase ]
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Mature Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Putative hsa-miR-216a-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_000314    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_000314|3'UTR
   1 ATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGG
  81 CAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCA
 161 CAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGAC
 241 ATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGAT
 321 GTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCAC
 401 ATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACATTCT
 481 AATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATATACC
 561 ATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGTCAC
 641 TGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGGGT
 721 ACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGC
 801 AACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTA
 881 TTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAG
 961 TACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCC
1041 TGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAA
1121 GCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACATTCT
1201 ATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATACAT
1281 ATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAAAAA
1361 AAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAA
1521 TTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTG
1601 TAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGAC
1681 ATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACT
1761 AGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCA
1841 AATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCATTC
1921 AACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATTGAT
2001 TGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTCTTT
2081 CATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTTAC
2161 AATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACAT
2241 TATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCA
2321 ATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATAT
2401 AAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAA
2481 AGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTG
2561 AGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTTTAA
2641 GAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAAGGG
2721 TAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAAATG
2801 TTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGATG
2881 GCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTG
2961 TGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTC
3041 ATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCT
3121 GTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCC
3201 TCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAAC
3281 TGATTAAAGTCTCATTCTTGTCA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' agUGUC----AACGGUCGACUCUAAu 5'
            ||||    || | | :||||||| 
Target 5' gcACAGAAATTTTCAATTTGAGATTc 3'
1087 - 1112 158.00 -12.80
2
miRNA  3' agugucAACGGUCGACUCUAAu 5'
                ||| : ||||| ||| 
Target 5' aacttaTTGGT-GCTGAAATTg 3'
1734 - 1754 123.00 -8.70
3
miRNA  3' agUGUCAA-CGGUCGACUCUAAu 5'
            :||||| ||:|   |||:|| 
Target 5' ttGCAGTTGGCTAAGAGAGGTTt 3'
436 - 458 120.00 -14.00
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-216a-5p :: PTEN    [ Functional MTI ]
Validation Method Other
Article - Kato, M. Putta, S. Wang, M. Yuan, H. et al.
- Nat Cell Biol, 2009
Akt kinase is activated by transforming growth factor-beta1 (TGF-beta) in diabetic kidneys, and has important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells. However, the mechanisms of Akt activation by TGF-beta are not fully understood. Here we show that TGF-beta activates Akt in glomerular mesangial cells by inducing the microRNAs (miRNAs) miR-216a and miR-217, both of which target PTEN (phosphatase and tensin homologue), an inhibitor of Akt activation. These miRNAs are located within the second intron of a non-coding RNA (RP23-298H6.1-001). The RP23 promoter was activated by TGF-beta and miR-192 through E-box-regulated mechanisms, as shown previously. Akt activation by these miRs led to glomerular mesangial cell survival and hypertrophy, which were similar to the effects of activation by TGF-beta. These studies reveal a mechanism of Akt activation through PTEN downregulation by two miRs, which are regulated by upstream miR-192 and TGF-beta. Due to the diversity of PTEN function, this miR-amplifying circuit may have key roles, not only in kidney disorders, but also in other diseases.
LinkOut: [PMID: 19543271]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-216a-5p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay , Western blot , Other
Location of target site 3'UTR
Article - Inui, M. Martello, G. Piccolo, S.
- Nat Rev Mol Cell Biol, 2010
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function. Signalling pathways are ideal candidates for miRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Indeed, emerging evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-beta, WNT, Notch and epidermal growth factor. As such, miRNAs serve as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
LinkOut: [PMID: 20216554]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-216a-5p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions PLC/PRF/5
Location of target site 3'UTR
Tools used in this research miRecord
Original Description (Extracted from the article) ... SMAD7 and PTEN are identified as two functional downstream targets of miR-216a /217 ...

- Xia, H. Ooi, L. L. Hui, K. M., 2013, Hepatology.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1
miRNA  3' agUGUC----AACGGUCGACUCUAAu 5'
            ||||    || | | :||||||| 
Target 5' -cACAGAAAUUUUCAAUUUGAGAUUc 3'
1 - 25
Article - Xia, H. Ooi, L. L. Hui, K. M.
- Hepatology, 2013
Tumor recurrence and metastases are the major obstacles to improving the prognosis of patients with hepatocellular carcinoma (HCC). To identify novel risk factors associated with HCC recurrence and metastases, we have established a panel of recurrence-associated microRNAs by comparing the microRNA expression in recurrent and non-recurrent human HCC tissue samples using microarrays (recurrence is defined as recurrent disease occurring within a 2-year time point of the original treatment). Among the panel, expression of the miR-216a/217 cluster was consistently and significantly upregulated in HCC tissue samples and cell lines associated with early tumor recurrence, poor disease-free survival and an epithelial-mesenchymal transition (EMT) phenotype. Stable over-expression of miR-216a/217-induced EMT, increased the stemlike cell population, migration and metastatic ability of epithelial HCC cells. PTEN and SMAD7 were subsequently identified as two functional targets of miR-216a/217, and both PTEN and SMAD7 were downregulated in HCC. Ectopic expression of PTEN or SMAD7 partially rescued miR-216a/217-mediated EMT, cell migration and stem-like properties of HCC cells. Previously, SMAD7 was shown to be a TGF-beta type 1 receptor antagonist. Here, we further demonstrated that the overexpression of miR-216a/217 acted as a positive feedback regulator for the TGF-beta pathway and the canonical pathway involved in the activation of PI3K/Akt signaling in HCC cells. Additionally, activation of the TGF-beta and PI3K/Akt signaling pathways in HCC cells resulted in an acquired resistance to sorafenib, while blocking the activation of TGF-beta pathway overcame miR-216a/217-induced sorafenib resistance and prevented tumor metastases in HCC. Conclusion: our present study demonstrates that overexpression of miR-216a/217 activates the PI3K/Akt and TGF-beta pathways by targeting PTEN and SMAD7, contributing to hepatocarcinogenesis and tumor recurrence in HCC. (HEPATOLOGY 2013.).
LinkOut: [PMID: 23471579]
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
144 hsa-miR-216a-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 3 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1, autophagy related 4 2
MIRT067588 METAP2 methionyl aminopeptidase 2 1 3
MIRT099144 MYLIP myosin regulatory light chain interacting protein 1 6
MIRT162313 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1 1
MIRT230668 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1 1
MIRT256274 PHAX phosphorylated adaptor for RNA export 1 1
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 1 1
MIRT386825 RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 1 1
MIRT438816 HNF4A hepatocyte nuclear factor 4, alpha 1 1
MIRT464699 UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1 1
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 1 1
MIRT466046 TMEM189 transmembrane protein 189 1 1
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 1 3
MIRT472209 NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 1 2
MIRT472562 NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 1 2
MIRT478921 CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1 1
MIRT480121 CALR calreticulin 1 1
MIRT497754 OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 1 1
MIRT497967 TWISTNB TWIST neighbor 1 1
MIRT502882 CDK4 cyclin-dependent kinase 4 1 4
MIRT510191 MON1B MON1 homolog B (yeast) 1 2
MIRT512407 CD84 CD84 molecule 1 1
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 1 2
MIRT526257 DROSHA drosha, ribonuclease type III 1 1
MIRT528968 FAM19A3 family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 1 1
MIRT529599 C6orf132 chromosome 6 open reading frame 132 1 1
MIRT529776 ZNF486 zinc finger protein 486 1 1
MIRT530110 PSAPL1 prosaposin-like 1 (gene/pseudogene) 1 1
MIRT530504 FADS6 fatty acid desaturase domain family, member 6 1 1
MIRT531437 PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1 1
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 1 1
MIRT537286 GABPB1 GA binding protein transcription factor, beta subunit 1 1 1
MIRT538451 CNNM2 cyclin M2 1 1
MIRT543085 ACTB actin, beta 1 1
MIRT550982 ZNF254 zinc finger protein 254 1 1
MIRT556259 MAPRE2 microtubule-associated protein, RP/EB family, member 2 1 1
MIRT556639 LAMC1 laminin, gamma 1 (formerly LAMB2) 1 1
MIRT559127 C11orf57 chromosome 11 open reading frame 57 1 1
MIRT561405 TUBB2A tubulin, beta 2A class IIa 1 1
MIRT569677 SEC23B Sec23 homolog B (S. cerevisiae) 1 2
MIRT574660 KLHL15 kelch-like 15 (Drosophila) 1 1
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 1 1
MIRT617683 JRKL jerky homolog-like (mouse) 1 1
MIRT618540 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 1 1
MIRT620805 C1orf27 chromosome 1 open reading frame 27 1 1
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 1 1
MIRT622133 SP4 Sp4 transcription factor 1 1
MIRT624913 CTCFL CCCTC-binding factor (zinc finger protein)-like 1 1
MIRT625010 PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 1 1
MIRT626644 ZNF551 zinc finger protein 551 1 1
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 1 1
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 1 1
MIRT627963 NLK nemo-like kinase 1 1
MIRT628767 SRSF7 serine/arginine-rich splicing factor 7 1 1
MIRT629261 KDM2B lysine (K)-specific demethylase 2B 1 1
MIRT629422 ADM2 adrenomedullin 2 1 1
MIRT630238 SORD sorbitol dehydrogenase 1 1
MIRT631272 CENPM centromere protein M 1 2
MIRT631793 CLK4 CDC-like kinase 4 1 1
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 1 1
MIRT632485 RPS15A ribosomal protein S15a 1 1
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 1 1
MIRT632708 MTA3 metastasis associated 1 family, member 3 1 1
MIRT632815 INO80 INO80 homolog (S. cerevisiae) 1 1
MIRT635956 PLA2G12A phospholipase A2, group XIIA 1 1
MIRT636152 UBXN2A UBX domain protein 2A 1 1
MIRT636899 C5orf45 chromosome 5 open reading frame 45 1 2
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 1 1
MIRT637457 ZNF324B zinc finger protein 324B 1 1
MIRT637900 SLC19A3 solute carrier family 19, member 3 1 1
MIRT639826 ZNF638 zinc finger protein 638 1 1
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34, member 1 1 1
MIRT640681 ARSK arylsulfatase family, member K 1 1
MIRT641611 CAPN7 calpain 7 1 1
MIRT641676 AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1 1
MIRT646786 IL23R interleukin 23 receptor 1 1
MIRT648352 A2ML1 alpha-2-macroglobulin-like 1 1 1
MIRT649144 SPATA5 spermatogenesis associated 5 1 1
MIRT649254 TRIM65 tripartite motif containing 65 1 1
MIRT652491 TMEM178B transmembrane protein 178B 1 1
MIRT653308 SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 1 1
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1 1
MIRT654212 RNF19B ring finger protein 19B 1 1
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 1 1
MIRT655159 PHF21A PHD finger protein 21A 1 1
MIRT655316 PDCD11 programmed cell death 11 1 1
MIRT655375 PAX3 paired box 3 1 1
MIRT657301 HOXB5 homeobox B5 1 1
MIRT657593 GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1 1
MIRT658460 FAM117B family with sequence similarity 117, member B 1 1
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 1 1
MIRT661640 UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 1 1
MIRT661712 MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae) 1 2
MIRT661833 ZNF793 zinc finger protein 793 1 1
MIRT663805 BET1L blocked early in transport 1 homolog (S. cerevisiae)-like 1 1
MIRT663884 CXorf56 chromosome X open reading frame 56 1 1
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 1 1
MIRT665814 TMEM168 transmembrane protein 168 1 1
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 1 1
MIRT668430 FAM20B family with sequence similarity 20, member B 1 1
MIRT672306 GP2 glycoprotein 2 (zymogen granule membrane) 1 1
MIRT673101 SYNPO2L synaptopodin 2-like 1 1
MIRT673437 APAF1 apoptotic peptidase activating factor 1 1 1
MIRT673584 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 1 1
MIRT673718 SLU7 SLU7 splicing factor homolog (S. cerevisiae) 1 1
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 1 1
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) 1 1
MIRT674820 FAM229B chromosome 6 open reading frame 225 1 1
MIRT675179 BPTF bromodomain PHD finger transcription factor 1 1
MIRT675586 WWC1 WW and C2 domain containing 1 1 1
MIRT675812 MED28 mediator complex subunit 28 1 1
MIRT677632 ALG1 asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT683914 PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 1 1
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase-like 1 1
MIRT691973 PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 1 1
MIRT693078 AS3MT arsenic (+3 oxidation state) methyltransferase 1 1
MIRT694084 RNASEH2B ribonuclease H2, subunit B 1 1
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 1 1
MIRT696541 C3 complement component 3 1 1
MIRT701955 MITF microphthalmia-associated transcription factor 1 1
MIRT703276 GNG12 guanine nucleotide binding protein (G protein), gamma 12 1 1
MIRT706852 DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 1 1
MIRT706993 XPO5 exportin 5 1 1
MIRT710716 KRTAP6-1 keratin associated protein 6-1 1 1
MIRT711305 ACOX1 acyl-CoA oxidase 1, palmitoyl 1 1
MIRT711514 ESCO1 establishment of cohesion 1 homolog 1 (S. cerevisiae) 1 1
MIRT711648 LIPG lipase, endothelial 1 1
MIRT711772 CCDC59 coiled-coil domain containing 59 1 1
MIRT714280 COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 1 1
MIRT715048 PRPF38A PRP38 pre-mRNA processing factor 38 (yeast) domain containing A 1 1
MIRT716934 INCENP inner centromere protein antigens 135/155kDa 1 1
MIRT717220 OTUD3 OTU domain containing 3 1 1
MIRT717865 BICD2 bicaudal D homolog 2 (Drosophila) 1 1
MIRT718836 SNX20 sorting nexin 20 1 1
MIRT720243 GPBP1 GC-rich promoter binding protein 1 1 1
MIRT721969 MCM8 minichromosome maintenance complex component 8 1 1
MIRT724000 LMTK2 lemur tyrosine kinase 2 1 1
MIRT725193 SDAD1 SDA1 domain containing 1 1 1
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