Accession ID: MIRT002958 [miRNA, hsa-miR-19a-3p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-19aLinkOut: [miRBase ]
Synonyms MIRN19A, hsa-mir-19a, miR-19a, miRNA19A, MIR19A
Description Homo sapiens miR-19a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-19a-3p
Mature Sequence 49| UGUGCAAAUCUAUGCAAAACUGA |71
Evidence Experimental
Experiments Cloned
Putative hsa-miR-19a-3p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_000314    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_000314|3'UTR
   1 ATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGG
  81 CAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCA
 161 CAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGAC
 241 ATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGAT
 321 GTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCAC
 401 ATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACATTCT
 481 AATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATATACC
 561 ATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGTCAC
 641 TGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGGGT
 721 ACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGC
 801 AACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTA
 881 TTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAG
 961 TACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCC
1041 TGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAA
1121 GCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACATTCT
1201 ATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATACAT
1281 ATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAAAAA
1361 AAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAA
1521 TTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTG
1601 TAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGAC
1681 ATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACT
1761 AGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCA
1841 AATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCATTC
1921 AACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATTGAT
2001 TGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTCTTT
2081 CATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTTAC
2161 AATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACAT
2241 TATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCA
2321 ATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATAT
2401 AAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAA
2481 AGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTG
2561 AGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTTTAA
2641 GAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAAGGG
2721 TAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAAATG
2801 TTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGATG
2881 GCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTG
2961 TGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTC
3041 ATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCT
3121 GTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCC
3201 TCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAAC
3281 TGATTAAAGTCTCATTCTTGTCA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' agUCAAAACGUAUCUAAACGUGu 5'
            | ||||||  || ||||||| 
Target 5' tgAATTTTGC--AGTTTTGCACa 3'
1208 - 1228 169.00 -15.10
2
miRNA  3' agucaAAACGUAUCU--AAACGUGu 5'
               ||   ||:|:  ||||||| 
Target 5' tgacaTTATAATGGGCTTTTGCACt 3'
2235 - 2259 148.00 -8.80
3
miRNA  3' agucaaaacguaucuAAACGUGu 5'
                         ||||||| 
Target 5' ttcacatcctaccccTTTGCACt 3'
396 - 418 140.00 -5.60
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay , Reporter assay
Conditions HeLa
Location of target site 3'UTR
Original Description (Extracted from the article) ... Experimental Support for Predicted Targets.//{These MTI shown in Fig. 3} ...

- Lewis, B. P. Shih, I. H. Jones-Rhoades, M. et al., 2003, Cell.

Article - Lewis, B. P. Shih, I. H. Jones-Rhoades, M. et al.
- Cell, 2003
MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and plants by basepairing to mRNAs to specify posttranscriptional repression of these messages. However, the mRNAs regulated by vertebrate miRNAs are all unknown. Here we predict more than 400 regulatory target genes for the conserved vertebrate miRNAs by identifying mRNAs with conserved pairing to the 5' region of the miRNA and evaluating the number and quality of these complementary sites. Rigorous tests using shuffled miRNA controls supported a majority of these predictions, with the fraction of false positives estimated at 31% for targets identified in human, mouse, and rat and 22% for targets identified in pufferfish as well as mammals. Eleven predicted targets (out of 15 tested) were supported experimentally using a HeLa cell reporter system. The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
LinkOut: [PMID: 14697198]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method qRT-PCR , Western blot , Other
Conditions 158 patients with CS, CSL, or BRRS
Location of target site 3'UTR
Original Description (Extracted from the article) ... Taken together, our study results suggest that differential expression of PTEN-targeting miR-19a and miR-21 modulates the PTEN protein levels and the CS and CSL phenotypes, irrespective of the patient’s mutation status, and support their roles as genetic modifiers in CS and CSL. ...

- Pezzolesi, M. G. Platzer, P. Waite, K. A. Eng, C., 2008, Am J Hum Genet.

Article - Pezzolesi, M. G. Platzer, P. Waite, K. A. Eng, C.
- Am J Hum Genet, 2008
Germline mutations in the gene encoding phosphatase and tensin homolog deleted on chromosome ten (PTEN [MIM 601728]) are associated with a number of clinically distinct heritable cancer syndromes, including both Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRRS). Seemingly identical pathogenic PTEN mutations have been observed in patients with CS and BRRS, as well as in patients with incomplete features of CS, referred to as CS-like (CSL) patients. These observations indicate that additional, unidentified, genetic and epigenetic factors act as phenotypic modifiers in these disorders. These genetic factors could also contribute to disease in patients with CS, CSL, or BRRS without identifiable PTEN mutations. Two potential modifiers are miR-19a and miR-21, which are previously identified PTEN-targeting miRNAs. We investigated the role of these miRNAs by characterizing their relative expression levels in PTEN-mutation-positive and PTEN-mutation-negative patients with CS, CSL, or BRRS. Interestingly, we observed differential expression of miR-19a and miR-21 in our PTEN-mutation-positive patients. Both were found to be significantly overexpressed within this group (p < 0.01) and were inversely correlated with germline PTEN protein levels. Similarly, the relative expression of miR-19a and miR-21 was differentially expressed in a series of PTEN-mutation-negative patients with CS or CSL with variable clinical phenotypes and decreased full-length PTEN protein expression. Among PTEN-mutation-positive patients with CS, both miRNAs were significantly overexpressed (p = 0.006-0.013). Taken together, our study results suggest that differential expression of PTEN-targeting miR-19a and miR-21 modulates the PTEN protein levels and the CS and CSL phenotypes, irrespective of the patient's mutation status, and support their roles as genetic modifiers in CS and CSL.
LinkOut: [PMID: 18460397]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method Other
Article - Wang, L. Pal, S. Sif, S.
- Mol Cell Biol, 2008
The proper epigenetic modification of chromatin by protein arginine methyltransferases (PRMTs) is crucial for normal cell growth and health. The human SWI/SNF-associated PRMT5 is involved in the transcriptional repression of target genes by directly methylating H3R8 and H4R3. To further understand the impact of PRMT5-mediated histone methylation on cancer, we analyzed its expression in normal and transformed human B lymphocytes. Our findings reveal that PRMT5 protein levels are enhanced in various human lymphoid cancer cells, including transformed chronic lymphocytic leukemia (B-CLL) cell lines. PRMT5 overexpression is caused by the altered expression of the PRMT5-specific microRNAs 19a, 25, 32, 92, 92b, and 96 and results in the increased global symmetric methylation of H3R8 and H4R3. An evaluation of both epigenetic marks at PRMT5 target genes such as RB1 (p105), RBL1 (p107), and RBL2 (p130) showed that promoters H3R8 and H4R3 are hypermethylated, which in turn triggers pocket protein transcriptional repression. Furthermore, reducing PRMT5 expression in WaC3CD5 B-CLL cells abolishes H3R8 and H4R3 hypermethylation, restores RBL2 expression, and inhibits cancer cell proliferation. These results indicate that PRMT5 overexpression epigenetically alters the transcription of key tumor suppressor genes and suggest a causal role of the elevated symmetric methylation of H3R8 and H4R3 at the RBL2 promoter in transformed B-lymphocyte pathology.
LinkOut: [PMID: 18694959]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions DU145 , PWR-1E
Location of target site 3'UTR
Tools used in this research miRanda , miRBase Target Database , PicTar , TargetScanS
Original Description (Extracted from the article) ... Direct interaction of miR-17, 19, 22, 25 and 302 with PTEN 3'UTR. ...

- Poliseno, L. Salmena, L. Riccardi, L. et al., 2010, Sci Signal.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1
miRNA  3' agUCAAAACGUAUCUAAACGUGu 5'
            | ||||||  || ||||||| 
Target 5' tgAATTTTGC--AGTTTTGCAC- 3'
3 - 22
Article - Poliseno, L. Salmena, L. Riccardi, L. et al.
- Sci Signal, 2010
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor that antagonizes signaling through the phosphatidylinositol 3-kinase-Akt pathway. We have demonstrated that subtle decreases in PTEN abundance can have critical consequences for tumorigenesis. Here, we used a computational approach to identify miR-22, miR-25, and miR-302 as three PTEN-targeting microRNA (miRNA) families found within nine genomic loci. We showed that miR-22 and the miR-106b~25 cluster are aberrantly overexpressed in human prostate cancer, correlate with abundance of the miRNA processing enzyme DICER, and potentiate cellular transformation both in vitro and in vivo. We demonstrated that the intronic miR-106b~25 cluster cooperates with its host gene MCM7 in cellular transformation both in vitro and in vivo, so that the concomitant overexpression of MCM7 and the miRNA cluster triggers prostatic intraepithelial neoplasia in transgenic mice. Therefore, the MCM7 gene locus delivers two simultaneous oncogenic insults when amplified or overexpressed in human cancer. Thus, we have uncovered a proto-oncogenic miRNA-dependent network for PTEN regulation and defined the MCM7 locus as a critical factor in initiating prostate tumorigenesis.
LinkOut: [PMID: 20388916]
Experimental Support 5 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay , qRT-PCR , Western blot
Conditions MDR human breast cancer cell lines, MCF-7/TX200, MCF-7/VP-16, MCF-7/MX100 and wild-type MCF-7 (MCF7/WT)
Disease multidrug resistance (MDR) of breast cancer cells
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... MiR-19 Directly Targets PTEN ...

- Liang, Z. Li, Y. Huang, K. Wagar, N. Shim, H., 2011, Pharm Res.

Article - Liang, Z. Li, Y. Huang, K. Wagar, N. Shim, H.
- Pharm Res, 2011
PURPOSE: To explore whether miR-19 is involved in the regulation of multidrug resistance (MDR), one of the main causes of breast cancer mortality, and modulates sensitivity of tumor cells to chemotherapeutic agents. METHODS: We analyzed miRNA expression levels in three MDR cell lines in comparison with their parent cell line, MCF-7, using a miRNA microarray. We investigated whether inhibitor of miR-19 sensitized MDR cells to chemotherapeutic agents in vitro and in vivo. RESULTS: MiR-19 was overexpressed in all three MDR cell lines compared to their parental cell line, MCF-7. Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN. Inhibitor of miR-19a restored sensitivity of MDR cells to cytotoxic agents; administration of LNA-antimiR-19a, a chemo-modified miR-19a inhibitor, sensitized MDR cells to chemotherapeutic agents in vivo. CONCLUSION: Our findings demonstrate, for the first time, involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells.
LinkOut: [PMID: 21853360]
Experimental Support 6 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method
Article - Riley, K. J. Rabinowitz, G. S. Yario, T. A. et al.
- EMBO J, 2012
Epstein-Barr virus (EBV) controls gene expression to transform human B cells and maintain viral latency. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) identified mRNA targets of 44 EBV and 310 human microRNAs (miRNAs) in Jijoye (Latency III) EBV-transformed B cells. While 25% of total cellular miRNAs are viral, only three viral mRNAs, all latent transcripts, are targeted. Thus, miRNAs do not control the latent/lytic switch by targeting EBV lytic genes. Unexpectedly, 90% of the 1664 human 3'-untranslated regions targeted by the 12 most abundant EBV miRNAs are also targeted by human miRNAs via distinct binding sites. Half of these are targets of the oncogenic miR-17 approximately 92 miRNA cluster and associated families, including mRNAs that regulate transcription, apoptosis, Wnt signalling, and the cell cycle. Reporter assays confirmed the functionality of several EBV and miR-17 family miRNA-binding sites in EBV latent membrane protein 1 (LMP1), EBV BHRF1, and host CAPRIN2 mRNAs. Our extensive list of EBV and human miRNA targets implicates miRNAs in the control of EBV latency and illuminates viral miRNA function in general.
LinkOut: [PMID: 22473208]
Experimental Support 7 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method
Article - Wang, F. Li, T. Zhang, B. Li, H. Wu, Q. et al.
- Biochem Biophys Res Commun, 2013
Multidrug resistance (MDR) is the major cause of failure of gastric cancer chemotherapy. Members of the miR-17-92 cluster, including miR-19a/b, are considered oncomiRs and influence multiple aspects of the malignant phenotype of gastric cancer. However, the role of miR-19a/b in MDR in gastric cancer and its underlying mechanism remain unclear. In this study, we found that miR-19a/b were upregulated in MDR cell lines. Our results also showed that miR-19a/b upregulation decreased the sensitivity of gastric cancer cells to anticancer drugs. We further confirmed that miR-19a/b accelerated the ADR efflux of gastric cancer cells by increasing the levels of mdr1 and P-gp and that miR-19a/b suppressed drug-induced apoptosis by regulating Bcl-2 and Bax. Finally, we verified that PTEN, an inhibitor of AKT phosphorylation, is the functional target of miR-19a/b. Overall, these findings demonstrated that miR-19a/b promote MDR in gastric cancer cells by targeting PTEN.
LinkOut: [PMID: 23603256]
Experimental Support 8 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: PTEN    [ Functional MTI ]
Validation Method
Article - Jia, Z. Wang, K. Zhang, A. Wang, G. Kang, et al.
- Pathol Oncol Res, 2013
Astrocytic gliomas are the most common type of human primary brain tumors with poor prognosis. MicroRNAs(miRs) are frequently deregulated in gliomas and play an oncogenic or tumor suppressor role. In our previous study we found that miR-19a and miR-19b were up-regulated in malignant glioma cell lines by microRNA array. For further validation of this finding, the expression of miR-19a and miR-19b was detected by qRT-PCR and in situ hybridization(ISH) in 8 malignant glioma cell lines, 43 freshly resected glioma samples and 75 archival paraffin embedded glioma specimens with different grades of malignancy in the present study. The results demonstrate that miR-19a and miR-19b are overexpressed in glioma cell lines and astrocytic glioma tissues, and their expression level is positively correlated with tumor grades. Additionally, the tumor suppressor gene PTEN is identified as the target of miR-19a and miR-19b by Luciferase assay. It is speculated that miR-19a and miR-19b may have an oncogenic role in gliomagenesis at least partially via the negative regulation of PTEN and the molecular mechanism of gliomagenesis in which miR 19a and miR-19b involved should be investigated further.
LinkOut: [PMID: 23824915]
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
550 hsa-miR-19a-3p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001794 HOXA5 homeobox A5 2 2
MIRT001795 MECP2 methyl CpG binding protein 2 (Rett syndrome) 4 4
MIRT002958 PTEN phosphatase and tensin homolog 5 9
MIRT003214 ESR1 estrogen receptor 1 4 2
MIRT003426 CCND1 cyclin D1 5 3
MIRT003533 ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 3 3
MIRT003536 NR4A2 nuclear receptor subfamily 4, group A, member 2 3 3
MIRT003781 ATXN1 ataxin 1 5 4
MIRT004334 KAT2B K(lysine) acetyltransferase 2B 3 2
MIRT004337 SOCS1 suppressor of cytokine signaling 1 5 7
MIRT004350 PRMT5 protein arginine methyltransferase 5 2 2
MIRT004452 BCL2L11 BCL2-like 11 (apoptosis facilitator) 2 5
MIRT004593 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4 8
MIRT004934 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 5 5
MIRT005396 ARIH2 ariadne homolog 2 (Drosophila) 2 2
MIRT005630 SMAD4 SMAD family member 4 4 7
MIRT006179 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4 1
MIRT006475 CUL5 cullin 5 2 1
MIRT006646 TLR2 toll-like receptor 2 3 1
MIRT006787 TNF tumor necrosis factor 3 2
MIRT007118 SUZ12 suppressor of zeste 12 homolog (Drosophila) 2 2
MIRT007119 RAB13 RAB13, member RAS oncogene family 1 1
MIRT007120 MSMO1 methylsterol monooxygenase 1 2 3
MIRT007121 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1 1
MIRT007122 PSAP prosaposin 2 2
MIRT031304 THBS1 thrombospondin 1 2 2
MIRT031305 CTGF connective tissue growth factor 1 1
MIRT031306 DPYSL2 dihydropyrimidinase-like 2 1 1
MIRT031307 VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 1 1
MIRT031308 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 1 1
MIRT031309 RAB14 RAB14, member RAS oncogene family 2 3
MIRT050641 KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1 1
MIRT050642 RNF4 ring finger protein 4 1 1
MIRT050643 PRRC2C proline-rich coiled-coil 2C 1 1
MIRT050644 TMEM87A transmembrane protein 87A 1 1
MIRT050645 MTF2 metal response element binding transcription factor 2 1 1
MIRT050646 GRK6 G protein-coupled receptor kinase 6 1 1
MIRT050647 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 1 1
MIRT050648 WDFY3 WD repeat and FYVE domain containing 3 1 1
MIRT052969 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1 1
MIRT053155 MXD1 MAX dimerization protein 1 3 1
MIRT053165 TF transferrin 3 1
MIRT053789 IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 4 2
MIRT053790 NPEPL1 aminopeptidase-like 1 3 1
MIRT054156 AKT1 v-akt murine thymoma viral oncogene homolog 1 2 2
MIRT054459 ZBTB4 zinc finger and BTB domain containing 4 2 5
MIRT056046 MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 1 1
MIRT056174 OTUD1 OTU domain containing 1 1 1
MIRT056383 ZMYND11 zinc finger, MYND-type containing 11 1 2
MIRT057490 CEP55 centrosomal protein 55kDa 1 2
MIRT057811 SLC30A7 solute carrier family 30 (zinc transporter), member 7 1 2
MIRT060676 KLHL20 kelch-like 20 (Drosophila) 1 1
MIRT060822 CEP350 centrosomal protein 350kDa 1 3
MIRT062706 MLEC malectin 1 3
MIRT063592 FBXO28 F-box protein 28 1 2
MIRT063711 WDR26 WD repeat domain 26 1 2
MIRT063998 KLHL42 kelch domain containing 5 1 1
MIRT064747 CCND2 cyclin D2 1 5
MIRT064795 ZBTB18 zinc finger protein 238 1 2
MIRT065616 CLIC4 chloride intracellular channel 4 1 1
MIRT065885 RAB5B RAB5B, member RAS oncogene family 1 5
MIRT066882 RAB21 RAB21, member RAS oncogene family 1 1
MIRT066935 SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1 1
MIRT067193 STX12 syntaxin 12 1 1
MIRT068828 FNDC3A fibronectin type III domain containing 3A 1 1
MIRT069290 WDR20 WD repeat domain 20 1 1
MIRT069422 SIVA1 SIVA1, apoptosis-inducing factor 1 2
MIRT070993 SMOC1 SPARC related modular calcium binding 1 1 1
MIRT071086 RBM25 RNA binding motif protein 25 1 1
MIRT071480 CALM1 calmodulin 1 (phosphorylase kinase, delta) 1 1
MIRT071816 RNF11 ring finger protein 11 1 4
MIRT071901 ZFYVE9 zinc finger, FYVE domain containing 9 1 1
MIRT072478 RAB8B RAB8B, member RAS oncogene family 1 1
MIRT073803 ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 1 2
MIRT074500 NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1 2
MIRT074889 CHD9 chromodomain helicase DNA binding protein 9 1 1
MIRT075110 C16ORF70 chromosome 16 open reading frame 70 1 3
MIRT075330 SF3B3 splicing factor 3b, subunit 3, 130kDa 1 2
MIRT076024 COX10 cytochrome c oxidase assembly homolog 10 (yeast) 1 4
MIRT076583 NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 1 1
MIRT079342 CCDC137 coiled-coil domain containing 137 1 2
MIRT079465 FN3KRP fructosamine 3 kinase related protein 1 1
MIRT079744 RBBP8 retinoblastoma binding protein 8 1 1
MIRT080177 PRKACB protein kinase, cAMP-dependent, catalytic, beta 1 1
MIRT080680 KIAA1468 KIAA1468 1 1
MIRT081116 LDLR low density lipoprotein receptor 1 4
MIRT082387 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 1 3
MIRT083229 GINS1 GINS complex subunit 1 (Psf1 homolog) 1 1
MIRT085259 CCNT2 cyclin T2 1 1
MIRT085515 SLC37A1 solute carrier family 37 (glycerol-3-phosphate transporter), member 1 1 1
MIRT086398 MFSD6 major facilitator superfamily domain containing 6 1 1
MIRT087602 ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1 1
MIRT087862 CBY1 chibby homolog 1 (Drosophila) 1 2
MIRT087928 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT090333 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1 5
MIRT090801 MBNL1 muscleblind-like splicing regulator 1 1 3
MIRT090896 ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 1 1
MIRT091211 USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 1 1
MIRT091231 FXR1 fragile X mental retardation, autosomal homolog 1 1 1
MIRT091938 ZBTB47 zinc finger and BTB domain containing 47 1 3
MIRT092024 ABHD5 abhydrolase domain containing 5 1 3
MIRT092487 PTPRG protein tyrosine phosphatase, receptor type, G 1 1
MIRT092954 CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1 2
MIRT093076 SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1 1
MIRT094087 PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1 3
MIRT094221 G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1 5
MIRT094526 C5ORF30 chromosome 5 open reading frame 30 1 1
MIRT095135 C5ORF24 chromosome 5 open reading frame 24 1 1
MIRT095198 SMAD5 SMAD family member 5 1 1
MIRT095995 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 1 1
MIRT097459 PAPD4 PAP associated domain containing 4 1 1
MIRT097556 RASA1 RAS p21 protein activator (GTPase activating protein) 1 1 1
MIRT097688 ARRDC3 arrestin domain containing 3 1 1
MIRT099306 QKI QKI, KH domain containing, RNA binding 1 2
MIRT099822 SOX4 SRY (sex determining region Y)-box 4 1 5
MIRT100760 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 1 2
MIRT101801 PNRC1 proline-rich nuclear receptor coactivator 1 1 1
MIRT102245 HBP1 HMG-box transcription factor 1 1 3
MIRT102566 CREB3L2 cAMP responsive element binding protein 3-like 2 1 1
MIRT102614 UBN2 ubinuclein 2 1 4
MIRT104392 ANKIB1 ankyrin repeat and IBR domain containing 1 1 1
MIRT105199 EFR3A EFR3 homolog A (S. cerevisiae) 1 1
MIRT105302 VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1 1
MIRT105429 ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1 6
MIRT107274 FAM73B family with sequence similarity 73, member B 1 1
MIRT107488 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1 1
MIRT108873 HPRT1 hypoxanthine phosphoribosyltransferase 1 1 1
MIRT109826 MID1IP1 MID1 interacting protein 1 1 4
MIRT112758 ADIPOR2 adiponectin receptor 2 1 1
MIRT113257 TMBIM6 transmembrane BAX inhibitor motif containing 6 1 3
MIRT113580 ZDHHC18 zinc finger, DHHC-type containing 18 1 1
MIRT113882 KPNA6 karyopherin alpha 6 (importin alpha 7) 1 3
MIRT117352 TGIF1 TGFB-induced factor homeobox 1 1 2
MIRT125560 SCD stearoyl-CoA desaturase (delta-9-desaturase) 1 1
MIRT126661 RAB18 RAB18, member RAS oncogene family 1 1
MIRT127082 REEP3 receptor accessory protein 3 1 1
MIRT127203 PLAU plasminogen activator, urokinase 1 1
MIRT127441 FAS Fas (TNF receptor superfamily, member 6) 1 1
MIRT129454 CHEK1 checkpoint kinase 1 1 1
MIRT129779 FAM46C family with sequence similarity 46, member C 1 1
MIRT129958 TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1 1
MIRT130677 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT130845 ZBTB7B zinc finger and BTB domain containing 7B 1 1
MIRT132676 RASSF5 Ras association (RalGDS/AF-6) domain family member 5 1 1
MIRT132981 WNK1 WNK lysine deficient protein kinase 1 1 1
MIRT133161 GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1 1
MIRT133376 BCL7A B-cell CLL/lymphoma 7A 1 1
MIRT134301 GPR137B G protein-coupled receptor 137B 1 1
MIRT136439 PLXNC1 plexin C1 1 1
MIRT137249 AGO1 eukaryotic translation initiation factor 2C, 1 1 1
MIRT137289 MBNL2 muscleblind-like splicing regulator 2 1 1
MIRT137383 MACF1 microtubule-actin crosslinking factor 1 1 1
MIRT137540 RCOR1 REST corepressor 1 1 1
MIRT138187 KLHDC2 kelch domain containing 2 1 1
MIRT138346 FRMD6 FERM domain containing 6 1 1
MIRT139871 BTF3L4 basic transcription factor 3-like 4 1 4
MIRT139915 KLF13 Kruppel-like factor 13 1 1
MIRT140246 DMXL2 Dmx-like 2 1 1
MIRT140961 NPTN neuroplastin 1 1
MIRT141350 ABHD17C family with sequence similarity 108, member C1 1 1
MIRT141934 SMG1 smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 1 5
MIRT142377 TNRC6A trinucleotide repeat containing 6A 1 3
MIRT142988 TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1 1
MIRT144147 PHF13 PHD finger protein 13 1 1
MIRT144488 MIER1 mesoderm induction early response 1 homolog (Xenopus laevis) 1 1
MIRT144865 MAP2K3 mitogen-activated protein kinase kinase 3 1 1
MIRT145462 NF1 neurofibromin 1 1 1
MIRT147074 DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1 1
MIRT147919 CAMTA1 calmodulin binding transcription activator 1 1 1
MIRT147970 VAMP3 vesicle-associated membrane protein 3 1 1
MIRT148866 ANKRD12 ankyrin repeat domain 12 1 1
MIRT149309 PDE4A phosphodiesterase 4A, cAMP-specific 1 1
MIRT150380 CC2D1A coiled-coil and C2 domain containing 1A 1 1
MIRT150616 SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 1 1
MIRT151584 ZNF526 zinc finger protein 526 1 1
MIRT153283 FAM83D family with sequence similarity 83, member D 1 1
MIRT156402 RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1 1
MIRT156586 COQ10B coenzyme Q10 homolog B (S. cerevisiae) 1 1
MIRT157707 CAB39 calcium binding protein 39 1 1
MIRT158798 PPARA peroxisome proliferator-activated receptor alpha 1 1
MIRT159103 NRBP1 nuclear receptor binding protein 1 1 1
MIRT159677 AFTPH aftiphilin 1 1
MIRT162256 LMLN leishmanolysin-like (metallopeptidase M8 family) 1 2
MIRT162697 ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1 1
MIRT164476 RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1 1
MIRT166255 C5ORF51 chromosome 5 open reading frame 51 1 2
MIRT166399 MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1 1
MIRT168650 MAPK14 mitogen-activated protein kinase 14 1 1
MIRT170951 IKZF1 IKAROS family zinc finger 1 (Ikaros) 1 1
MIRT172151 FZD6 frizzled family receptor 6 1 5
MIRT172594 CNOT7 CCR4-NOT transcription complex, subunit 7 1 1
MIRT173377 TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 1 1
MIRT175592 OCRL oculocerebrorenal syndrome of Lowe 1 1
MIRT176283 DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 1 1
MIRT177384 WAC WW domain containing adaptor with coiled-coil 1 1
MIRT178061 SAMD8 sterile alpha motif domain containing 8 1 1
MIRT178924 C11ORF57 chromosome 11 open reading frame 57 1 2
MIRT179065 PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 1 3
MIRT179423 TBRG1 transforming growth factor beta regulator 1 1 3
MIRT187749 ESYT1 extended synaptotagmin-like protein 1 1 1
MIRT188209 RAP1B RAP1B, member of RAS oncogene family 1 1
MIRT193021 TMOD3 tropomodulin 3 (ubiquitous) 1 4
MIRT193529 RORA RAR-related orphan receptor A 1 2
MIRT195613 FAM195A family with sequence similarity 195, member A 1 3
MIRT195752 ATMIN ATM interactor 1 3
MIRT197826 DCAF7 DDB1 and CUL4 associated factor 7 1 2
MIRT203045 AMMECR1L AMME chromosomal region gene 1-like 1 2
MIRT208722 MED12L mediator complex subunit 12-like 1 3
MIRT209477 EIF4A2 eukaryotic translation initiation factor 4A2 1 4
MIRT211502 ELMOD2 ELMO/CED-12 domain containing 2 1 2
MIRT213428 MOB1B MOB kinase activator 1B 1 3
MIRT213702 AFF1 AF4/FMR2 family, member 1 1 1
MIRT213973 DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) 1 1
MIRT217599 NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 1 1
MIRT220279 TMEM106B transmembrane protein 106B 1 1
MIRT227992 NFIB nuclear factor I/B 1 2
MIRT230215 RPS4Y1 ribosomal protein S4, Y-linked 1 1 1
MIRT230963 PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1 1
MIRT243090 LCLAT1 lysocardiolipin acyltransferase 1 1 3
MIRT243389 SKIL SKI-like oncogene 1 5
MIRT245295 BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 1 1
MIRT248070 SLC38A2 solute carrier family 38, member 2 1 3
MIRT250718 DEF8 differentially expressed in FDCP 8 homolog (mouse) 1 1
MIRT251362 RNF167 ring finger protein 167 1 1
MIRT252920 BCL3 B-cell CLL/lymphoma 3 1 1
MIRT253410 EVI5L ecotropic viral integration site 5-like 1 2
MIRT259381 SLC6A8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 1 2
MIRT260199 KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 1 1
MIRT260227 ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 1 1
MIRT275173 BTG1 B-cell translocation gene 1, anti-proliferative 1 1
MIRT275508 ZIC5 Zic family member 5 1 1
MIRT278994 GMFB glia maturation factor, beta 1 6
MIRT280867 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 1 3
MIRT283021 NFIA nuclear factor I/A 1 1
MIRT284268 ALG1 asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT287194 STAT5B signal transducer and activator of transcription 5B 1 1
MIRT290693 POLI polymerase (DNA directed) iota 1 2
MIRT291961 CHERP calcium homeostasis endoplasmic reticulum protein 1 1
MIRT295902 DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) 1 1
MIRT296524 STX16 syntaxin 16 1 1
MIRT298581 BRWD1 bromodomain and WD repeat domain containing 1 1 2
MIRT313089 RNF44 ring finger protein 44 1 2
MIRT313686 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1 1
MIRT322045 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 2
MIRT323126 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 1 1
MIRT323692 PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 1 2
MIRT367152 HIST2H4A histone cluster 2, H4a 1 3
MIRT367176 HIST2H4B histone cluster 2, H4b 1 3
MIRT400560 MB21D2 Mab-21 domain containing 2 1 1
MIRT402567 ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 1 1
MIRT405626 WBP4 WW domain binding protein 4 1 2
MIRT438094 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT438478 CD22 CD22 molecule 2 1
MIRT438801 MYC v-myc myelocytomatosis viral oncogene homolog (avian) 1 1
MIRT438808 DNMT1 DNA (cytosine-5-)-methyltransferase 1 1 1
MIRT456095 MB21D1 Mab-21 domain containing 1 1 3
MIRT457965 PTPRB protein tyrosine phosphatase, receptor type, B 1 1
MIRT460412 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1 2
MIRT462956 ZNF800 zinc finger protein 800 1 7
MIRT463058 ZNF644 zinc finger protein 644 1 1
MIRT463650 YY1 YY1 transcription factor 1 4
MIRT463909 WNT7B wingless-type MMTV integration site family, member 7B 1 1
MIRT466377 TGOLN2 trans-golgi network protein 2 1 3
MIRT466813 STX6 syntaxin 6 1 4
MIRT468242 SGK1 serum/glucocorticoid regulated kinase 1 1 2
MIRT468564 SERINC3 serine incorporator 3 1 5
MIRT469279 RHOB ras homolog family member B 1 4
MIRT470338 PPP6R1 protein phosphatase 6, regulatory subunit 1 1 1
MIRT470388 PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 1 1
MIRT471566 PATL1 protein associated with topoisomerase II homolog 1 (yeast) 1 4
MIRT472561 NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 1 2
MIRT472785 MTMR6 myotubularin related protein 6 1 4
MIRT473735 MAP3K9 mitogen-activated protein kinase kinase kinase 9 1 1
MIRT474479 KLHL11 kelch-like 11 (Drosophila) 1 4
MIRT474747 KIF13A kinesin family member 13A 1 3
MIRT474952 KCTD10 potassium channel tetramerisation domain containing 10 1 2
MIRT475199 IMPDH1P11 IMP (inosine monophosphate) dehydrogenase 1 pseudogene 11 1 3
MIRT476915 FBLIM1 filamin binding LIM protein 1 1 2
MIRT477372 EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 1 2
MIRT477479 ELL2 elongation factor, RNA polymerase II, 2 1 1
MIRT478114 DLG5 discs, large homolog 5 (Drosophila) 1 3
MIRT478218 DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1 2
MIRT479662 CD164 CD164 molecule, sialomucin 1 2
MIRT479821 CCNA2 cyclin A2 1 4
MIRT480021 CAPRIN2 caprin family member 2 1 2
MIRT480846 BLCAP bladder cancer associated protein 1 6
MIRT481615 ARHGAP1 Rho GTPase activating protein 1 1 4
MIRT481864 ANKRD50 ankyrin repeat domain 50 1 1
MIRT482516 ACTB actin, beta 1 2
MIRT482595 ABHD14B abhydrolase domain containing 14B 1 1
MIRT483460 YTHDF1 YTH domain family, member 1 1 3
MIRT484947 ZFYVE26 zinc finger, FYVE domain containing 26 1 2
MIRT485130 SECISBP2L SECIS binding protein 2-like 1 3
MIRT485564 FOXQ1 forkhead box Q1 1 1
MIRT485653 DICER1 dicer 1, ribonuclease type III 1 2
MIRT485806 ARPP19 cAMP-regulated phosphoprotein, 19kDa 1 2
MIRT486737 CNOT4 CCR4-NOT transcription complex, subunit 4 1 3
MIRT491635 PDRG1 p53 and DNA-damage regulated 1 1 5
MIRT491940 WDR45B WDR45-like 1 4
MIRT492241 SLC48A1 solute carrier family 48 (heme transporter), member 1 1 1
MIRT493101 MMGT1 membrane magnesium transporter 1 1 6
MIRT494487 BRWD3 bromodomain and WD repeat domain containing 3 1 1
MIRT495274 NICN1 nicolin 1 1 2
MIRT496505 G6PC glucose-6-phosphatase, catalytic subunit 1 1
MIRT498464 PTBP2 polypyrimidine tract binding protein 2 1 5
MIRT500408 ZMAT3 zinc finger, matrin-type 3 1 5
MIRT500677 TRIM37 tripartite motif containing 37 1 1
MIRT501253 SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 1 4
MIRT501531 PPP1R15B protein phosphatase 1, regulatory subunit 15B 1 5
MIRT501662 PHLDA3 pleckstrin homology-like domain, family A, member 3 1 1
MIRT501792 NRBF2 nuclear receptor binding factor 2 1 3
MIRT501994 MAPK1 mitogen-activated protein kinase 1 1 5
MIRT502764 CLIP1 CAP-GLY domain containing linker protein 1 1 5
MIRT502979 CCNL1 cyclin L1 1 4
MIRT503054 CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 1 2
MIRT503467 ZNF154 zinc finger protein 154 1 3
MIRT503674 SLC46A1 solute carrier family 46 (folate transporter), member 1 1 1
MIRT505253 UBE2D3 ubiquitin-conjugating enzyme E2D 3 1 1
MIRT505526 SPATA2 spermatogenesis associated 2 1 2
MIRT505700 SESN3 sestrin 3 1 1
MIRT505788 SATB1 SATB homeobox 1 1 2
MIRT506351 NUP54 nucleoporin 54kDa 1 4
MIRT506470 NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1 2
MIRT506697 LZIC leucine zipper and CTNNBIP1 domain containing 1 2
MIRT507968 BEND3 BEN domain containing 3 1 4
MIRT509028 PALM2-AKAP2 PALM2-AKAP2 readthrough 1 1
MIRT509047 AKAP2 A kinase (PRKA) anchor protein 2 1 1
MIRT510563 USP8 ubiquitin specific peptidase 8 1 2
MIRT510725 SPG20 spastic paraplegia 20 (Troyer syndrome) 1 3
MIRT510856 RAN RAN, member RAS oncogene family 1 5
MIRT510948 PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 1 4
MIRT510985 PFN2 profilin 2 1 3
MIRT511153 MRPL17 mitochondrial ribosomal protein L17 1 3
MIRT511966 ELOVL5 ELOVL fatty acid elongase 5 1 4
MIRT512136 CREBL2 cAMP responsive element binding protein-like 2 1 5
MIRT512576 DCC deleted in colorectal carcinoma 1 2
MIRT512705 ZNF134 zinc finger protein 134 1 3
MIRT513482 ADRM1 adhesion regulating molecule 1 1 1
MIRT513597 ZFAND5 zinc finger, AN1-type domain 5 1 3
MIRT513625 VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 1 2
MIRT513720 RBM20 RNA binding motif protein 20 1 2
MIRT513914 GRB10 growth factor receptor-bound protein 10 1 3
MIRT513950 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 1 3
MIRT521318 RRAGD Ras-related GTP binding D 1 2
MIRT524508 CEP170 centrosomal protein 170kDa 1 2
MIRT529430 MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 1 1
MIRT530121 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1 1
MIRT533711 TMEM64 transmembrane protein 64 1 2
MIRT534274 SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7 1 1
MIRT535359 PFN1 profilin 1 1 1
MIRT538084 DGKH diacylglycerol kinase, eta 1 1
MIRT538502 CLOCK clock homolog (mouse) 1 2
MIRT539382 ADSS adenylosuccinate synthase 1 4
MIRT541005 ZNF367 zinc finger protein 367 1 2
MIRT541137 RAB34 RAB34, member RAS oncogene family 1 1
MIRT543097 TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1 1
MIRT543213 TMEM117 transmembrane protein 117 1 1
MIRT543559 RPF2 ribosome production factor 2 homolog (S. cerevisiae) 1 2
MIRT544722 NDRG1 N-myc downstream regulated 1 1 1
MIRT544977 MFF mitochondrial fission factor 1 2
MIRT545800 ZNF772 zinc finger protein 772 1 2
MIRT546397 STOX2 storkhead box 2 1 2
MIRT546426 SNX5 sorting nexin 5 1 1
MIRT546777 RLIM ring finger protein, LIM domain interacting 1 1
MIRT546860 RAB1A RAB1A, member RAS oncogene family 1 1
MIRT546958 SFTPA1 surfactant protein A1 1 1
MIRT547031 POGZ pogo transposable element with ZNF domain 1 1
MIRT547496 MBNL3 muscleblind-like splicing regulator 3 1 2
MIRT548085 GIGYF1 GRB10 interacting GYF protein 1 1 2
MIRT548105 GFPT1 glutamine--fructose-6-phosphate transaminase 1 1 2
MIRT548414 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 1 1
MIRT548507 E2F8 E2F transcription factor 8 1 2
MIRT548607 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) 1 1
MIRT548734 CREBRF CREB3 regulatory factor 1 1
MIRT548850 CERCAM cerebral endothelial cell adhesion molecule 1 1
MIRT548924 CHEK2 checkpoint kinase 2 1 2
MIRT549040 CASZ1 castor zinc finger 1 1 2
MIRT549185 BMP3 bone morphogenetic protein 3 1 1
MIRT549336 ARHGAP12 Rho GTPase activating protein 12 1 3
MIRT549357 ARC activity-regulated cytoskeleton-associated protein 1 1
MIRT549466 ACSL4 acyl-CoA synthetase long-chain family member 4 1 2
MIRT549492 ACBD5 acyl-CoA binding domain containing 5 1 2
MIRT550132 ZNF138 zinc finger protein 138 1 1
MIRT550205 MAVS mitochondrial antiviral signaling protein 1 2
MIRT550986 RBM38 RNA binding motif protein 38 1 1
MIRT551821 TMEM138 transmembrane protein 138 1 1
MIRT552148 DAD1 defender against cell death 1 1 2
MIRT552843 WNK3 WNK lysine deficient protein kinase 3 1 1
MIRT552877 WASL Wiskott-Aldrich syndrome-like 1 2
MIRT553207 UBE2A ubiquitin-conjugating enzyme E2A 1 1
MIRT553214 TXLNG taxilin gamma 1 1
MIRT553353 TRPC3 transient receptor potential cation channel, subfamily C, member 3 1 2
MIRT553390 TRIM33 tripartite motif containing 33 1 2
MIRT554049 SOX6 SRY (sex determining region Y)-box 6 1 1
MIRT554947 RAP1A RAP1A, member of RAS oncogene family 1 2
MIRT555086 PURG purine-rich element binding protein G 1 1
MIRT555201 PRUNE2 prune homolog 2 (Drosophila) 1 1
MIRT555245 PRICKLE2 prickle homolog 2 (Drosophila) 1 1
MIRT556080 MPRIP myosin phosphatase Rho interacting protein 1 2
MIRT556200 MCC mutated in colorectal cancers 1 1
MIRT556867 JAZF1 JAZF zinc finger 1 1 1
MIRT557212 HNRNPF heterogeneous nuclear ribonucleoprotein F 1 2
MIRT557567 GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1 1
MIRT557776 FRS2 fibroblast growth factor receptor substrate 2 1 2
MIRT557911 FBXO8 F-box protein 8 1 1
MIRT558267 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 1 1
MIRT558406 DEPDC1 DEP domain containing 1 1 1
MIRT558492 DBN1 drebrin 1 1 1
MIRT558776 CFL2 cofilin 2 (muscle) 1 1
MIRT559413 GDNF glial cell derived neurotrophic factor 1 2
MIRT559486 ARL8A ADP-ribosylation factor-like 8A 1 2
MIRT559688 AGO3 eukaryotic translation initiation factor 2C, 3 1 1
MIRT560046 ZNF680 zinc finger protein 680 1 1
MIRT560641 ZNF107 zinc finger protein 107 1 2
MIRT563097 PABPC4L poly(A) binding protein, cytoplasmic 4-like 1 1
MIRT563189 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 1 1
MIRT563798 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 1
MIRT564185 CLVS2 clavesin 2 1 1
MIRT564537 CCDC80 coiled-coil domain containing 80 1 1
MIRT564641 ZNF544 zinc finger protein 544 1 1
MIRT564784 ZDHHC7 zinc finger, DHHC-type containing 7 1 2
MIRT566160 RACGAP1 Rac GTPase activating protein 1 1 1
MIRT567525 FGFR1OP FGFR1 oncogene partner 1 1
MIRT571672 RRAS2 related RAS viral (r-ras) oncogene homolog 2 1 1
MIRT575745 Zfp618 zinc fingerprotein 618 1 1
MIRT614961 HOMER1 homer homolog 1 (Drosophila) 1 1
MIRT620045 ODF4 outer dense fiber of sperm tails 4 1 1
MIRT625044 MBD3 methyl-CpG binding domain protein 3 1 1
MIRT632672 MTX3 metaxin 3 1 1
MIRT644933 PTCD2 pentatricopeptide repeat domain 2 1 1
MIRT668496 ETV3 ets variant 3 1 1
MIRT675087 C6orf132 chromosome 6 open reading frame 132 1 1
MIRT681481 DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 1 1
MIRT683140 MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1 1
MIRT683184 UBL3 ubiquitin-like 3 1 1
MIRT693228 KIAA0907 KIAA0907 1 3
MIRT697757 USP37 ubiquitin specific peptidase 37 1 2
MIRT698245 TMEM2 transmembrane protein 2 1 1
MIRT698796 STK38 serine/threonine kinase 38 1 2
MIRT702410 KITLG KIT ligand 1 1
MIRT703537 FKBP15 FK506 binding protein 15, 133kDa 1 2
MIRT705008 CAMSAP1 calmodulin regulated spectrin-associated protein 1 1 1
MIRT715058 TMTC1 transmembrane and tetratricopeptide repeat containing 1 1 1
MIRT726019 ZNF721 zinc finger protein 721 1 1
MIRT726045 ZNF217 zinc finger protein 217 1 1
MIRT726094 XIAP X-linked inhibitor of apoptosis 1 1
MIRT726098 WNT10A wingless-type MMTV integration site family, member 10A 1 1
MIRT726107 WDR1 WD repeat domain 1 1 1
MIRT726112 WBP2 WW domain binding protein 2 1 1
MIRT726149 VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 1 1
MIRT726240 TRAK2 trafficking protein, kinesin binding 2 1 1
MIRT726244 TP53INP1 tumor protein p53 inducible nuclear protein 1 1 1
MIRT726245 TP53 tumor protein p53 1 1
MIRT726258 TNPO2 transportin 2 1 1
MIRT726260 TNIP1 TNFAIP3 interacting protein 1 1 1
MIRT726266 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1 1
MIRT726276 TMEM9B TMEM9 domain family, member B 1 1
MIRT726336 TFB1M transcription factor B1, mitochondrial 1 1
MIRT726395 TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 1 1
MIRT726424 STK4 serine/threonine kinase 4 1 1
MIRT726479 SNX17 sorting nexin 17 1 1
MIRT726500 SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 1 1
MIRT726553 SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1 1
MIRT726582 SHCBP1 SHC SH2-domain binding protein 1 1 1
MIRT726592 SH3KBP1 SH3-domain kinase binding protein 1 1 1
MIRT726628 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT726630 SEPHS2 selenophosphate synthetase 2 1 1
MIRT726638 SEL1L sel-1 suppressor of lin-12-like (C. elegans) 1 1
MIRT726640 SEC63 SEC63 homolog (S. cerevisiae) 1 1
MIRT726650 SBF2 SET binding factor 2 1 1
MIRT726672 S1PR2 sphingosine-1-phosphate receptor 2 1 1
MIRT726724 RNF216 ring finger protein 216 1 1
MIRT726736 RNF111 ring finger protein 111 1 1
MIRT726749 RGL1 ral guanine nucleotide dissociation stimulator-like 1 1 1
MIRT726782 RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1 1
MIRT726784 RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 1 1
MIRT726785 RAP2C RAP2C, member of RAS oncogene family 1 1
MIRT726795 RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 1 1
MIRT726819 RAB2B RAB2B, member RAS oncogene family 1 1
MIRT726855 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1 1
MIRT726939 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 1 1
MIRT726944 PIGS phosphatidylinositol glycan anchor biosynthesis, class S 1 1
MIRT726959 PGM2L1 phosphoglucomutase 2-like 1 1 1
MIRT726964 PGK1 phosphoglycerate kinase 1 1 1
MIRT727000 PCDH10 protocadherin 10 1 1
MIRT727013 PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 1 1
MIRT727030 OTUD7B OTU domain containing 7B 1 1
MIRT727035 OTUD4 OTU domain containing 4 1 1
MIRT727114 NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 1 1
MIRT727142 MTMR12 myotubularin related protein 12 1 1
MIRT727189 MKL2 MKL/myocardin-like 2 1 1
MIRT727217 MEF2A myocyte enhancer factor 2A 1 1
MIRT727225 MCM3AP-AS1 MCM3AP antisense RNA 1 1 1
MIRT727238 MBD4 methyl-CpG binding domain protein 4 1 1
MIRT727252 MAP3K14 mitogen-activated protein kinase kinase kinase 14 1 1
MIRT727293 LOC613266 uncharacterized LOC613266 1 1
MIRT727300 LIN9 lin-9 homolog (C. elegans) 1 1
MIRT727334 KLHL3 kelch-like 3 (Drosophila) 1 1
MIRT727351 KIF3A kinesin family member 3A 1 1
MIRT727359 CCSER2 family with sequence similarity 190, member B 1 1
MIRT727366 ATG14 autophagy related 14 1 1
MIRT727383 KATNAL1 katanin p60 subunit A-like 1 1 1
MIRT727400 JARID2 jumonji, AT rich interactive domain 2 1 1
MIRT727447 INO80 INO80 homolog (S. cerevisiae) 1 1
MIRT727487 HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 1 1
MIRT727495 HIPK3 homeodomain interacting protein kinase 3 1 1
MIRT727501 HIC1 hypermethylated in cancer 1 1 1
MIRT727502 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT727513 HDAC4 histone deacetylase 4 1 1
MIRT727525 GRSF1 G-rich RNA sequence binding factor 1 1 1
MIRT727530 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1 1
MIRT727607 GAK cyclin G associated kinase 1 1
MIRT727650 FOXP1 forkhead box P1 1 1
MIRT727663 FBXO48 F-box protein 48 1 1
MIRT727680 FBXO10 F-box protein 10 1 1
MIRT727697 FAM73A family with sequence similarity 73, member A 1 1
MIRT727721 DENND6A DENN/MADD domain containing 6A 1 1
MIRT727728 FAM102A family with sequence similarity 102, member A 1 1
MIRT727737 EXOC7 exocyst complex component 7 1 1
MIRT727753 EPS15 epidermal growth factor receptor pathway substrate 15 1 1
MIRT727759 EPN2 epsin 2 1 1
MIRT727790 EIF4E2 eukaryotic translation initiation factor 4E family member 2 1 1
MIRT727794 EHD1 EH-domain containing 1 1 1
MIRT727838 DUT deoxyuridine triphosphatase 1 1
MIRT727852 DSCR3 Down syndrome critical region gene 3 1 1
MIRT727971 CNOT6 CCR4-NOT transcription complex, subunit 6 1 1
MIRT727986 CIT citron (rho-interacting, serine/threonine kinase 21) 1 1
MIRT728042 CBX7 chromobox homolog 7 1 1
MIRT728043 CBX5 chromobox homolog 5 1 1
MIRT728061 IDNK idnK, gluconokinase homolog (E. coli) 1 1
MIRT728099 C2orf42 chromosome 2 open reading frame 42 1 1
MIRT728105 PRR14L proline rich 14-like 1 1
MIRT728121 SDE2 SDE2 telomere maintenance homolog (S. pombe) 1 1
MIRT728134 C15orf38 chromosome 15 open reading frame 38 1 1
MIRT728148 SPTSSA serine palmitoyltransferase, small subunit A 1 1
MIRT728155 GSKIP GSK3B interacting protein 1 1
MIRT728182 BTBD7 BTB (POZ) domain containing 7 1 1
MIRT728197 BRD9 bromodomain containing 9 1 1
MIRT728216 BCL7B B-cell CLL/lymphoma 7B 1 1
MIRT728235 B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1 1
MIRT728239 AZIN1 antizyme inhibitor 1 1 1
MIRT728245 ATXN7 ataxin 7 1 1
MIRT728248 ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 1 1
MIRT728272 ATG5 autophagy related 5 1 1
MIRT728274 ATG2B autophagy related 2B 1 1
MIRT728308 ARMC8 armadillo repeat containing 8 1 1
MIRT728318 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 1 1
MIRT728352 ANGEL2 angel homolog 2 (Drosophila) 1 1
MIRT728356 ALG2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT728370 AHDC1 AT hook, DNA binding motif, containing 1 1 1
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