Accession ID: MIRT003215 [miRNA, hsa-miR-421 :: ATM, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-421LinkOut: [miRBase ]
Synonyms MIRN421, hsa-mir-421, MIR421
Description Homo sapiens miR-421 stem-loop
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-421
Mature Sequence 48| AUCAACAGACAUUAAUUGGGCGC |70
Evidence Experimental
Experiments Microarray
Putative hsa-miR-421 Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol ATM LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Description ataxia telangiectasia mutated
Transcript NM_000051    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on ATM LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of ATM
(miRNA target sites are highlighted)
>ATM|NM_000051|3'UTR
   1 TCTTCAGTATATGAATTACCCTTTCATTCAGCCTTTAGAAATTATATTTTAGCCTTTATTTTTAACCTGCCAACATACTT
  81 TAAGTAGGGATTAATATTTAAGTGAACTATTGTGGGTTTTTTTGAATGTTGGTTTTAATACTTGATTTAATCACCACTCA
 161 AAAATGTTTTGATGGTCTTAAGGAACATCTCTGCTTTCACTCTTTAGAAATAATGGTCATTCGGGCTGGGCGCAGCGGCT
 241 CACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGCGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAAGA
 321 GACCAGCCTGGCCAGTATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGAGCATGGTGGCGGGCACCTGTA
 401 ATCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGTGAAGGTTGCTGTGGGCCAAAATCATGCC
 481 ATTGCACTCCAGCCTGGGTGACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAACAGAAACGTATTTGGATTTT
 561 TCCTAGTAAGATCACTCAGTGTTACTAAATAATGAAGTTGTTATGGAGAACAAATTTCAAAGACACAGTTAGTGTAGTTA
 641 CTATTTTTTTAAGTGTGTATTAAAACTTCTCATTCTATTCTCTTTATCTTTTAAGCCCTTCTGTACTGTCCATGTATGTT
 721 ATCTTTCTGTGATAACTTCATAGATTGCCTTCTAGTTCATGAATTCTCTTGTCAGATGTATATAATCTCTTTTACCCTAT
 801 CCATTGGGCTTCTTCTTTCAGAAATTGTTTTTCATTTCTAATTATGCATCATTTTTCAGATCTCTGTTTCTTGATGTCAT
 881 TTTTAATGTTTTTTTAATGTTTTTTATGTCACTAATTATTTTAAATGTCTGTACTTGATAGACACTGTAATAGTTCTATT
 961 AAATTTAGTTCCTGCTGTTTATATCTGTTGATTTTTGTATTTGATAGGCTGTTCATCCAGTTTTGTCTTTTTGAAAAGTG
1041 AGTTTATTTTCAGCAAGGCTTTATCTATGGGAATCTTGAGTGTCTGTTTATGTCATATTCCCAGGGCTGTTGCTGCACAC
1121 AAGCCCATTCTTATTTTAATTTCTTGGCTTTAGGGTTTCCATACCTGAAGTGTAGCATAAATACTGATAGGAGATTTCCC
1201 AGGCCAAGGCAAACACACTTCCTCCTCATCTCCTTGTGCTAGTGGGCAGAATATTTGATTGATGCCTTTTTCACTGAGAG
1281 TATAAGCTTCCATGTGTCCCACCTTTATGGCAGGGGTGGAAGGAGGTACATTTAATTCCCACTGCCTGCCTTTGGCAAGC
1361 CCTGGGTTCTTTGCTCCCCATATAGATGTCTAAGCTAAAAGCCGTGGGTTAATGAGACTGGCAAATTGTTCCAGGACAGC
1441 TACAGCATCAGCTCACATATTCACCTCTCTGGTTTTTCATTCCCCTCATTTTTTTCTGAGACAGAGTCTTGCTCTGTCAC
1521 CCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGAAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCC
1601 TCCCGAGTAGCTGGGACTACAGGCGTGTGCCAACACGCCCGGCTAATTTTTTGTATTTTTATTAGAGACGGAGTTTCACC
1681 GTGTTAGCCAGGATGGTCTCGATCGCTTGACCTCGTGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGT
1761 GAGCCACCGCGCCCGGCCTCATTCCCCTCATTTTTGACCGTAAGGATTTCCCCTTTCTTGTAAGTTCTGCTATGTATTTA
1841 AAAGAATGTTTTCTACATTTTATCCAGCATTTCTCTGTGTTCTGTTGGAAGGGAAGGGCTTAGGTATCTAGTTTGATACA
1921 TAGGTAGAAGTGGAACATTTCTCTGTCCCCCAGCTGTCATCATATAAGATAAACATCAGATAAAAAGCCACCTGAAAGTA
2001 AAACTACTGACTCGTGTATTAGTGAGTATAATCTCTTCTCCATCCTTAGGAAAATGTTCATCCCAGCTGCGGAGATTAAC
2081 AAATGGGTGATTGAGCTTTCTCCTCGTATTTGGACCTTGAAGGTTATATAAATTTTTTTCTTATGAAGAGTTGGCATTTC
2161 TTTTTATTGCCAATGGCAGGCACTCATTCATATTTGATCTCCTCACCTTCCCCTCCCCTAAAACCAATCTCCAGAACTTT
2241 TTGGACTATAAATTTCTTGGTTTGACTTCTGGAGAACTGTTCAGAATATTACTTTGCATTTCAAATTACAAACTTACCTT
2321 GGTGTATCTTTTTCTTACAAGCTGCCTAAATGAATATTTGGTATATATTGGTAGTTTTATTACTATAGTAAATCAAGGAA
2401 ATGCAGTAAACTTAAAATGTCTTTAAGAAAGCCCTGAAATCTTCATGGGTGAAATTAGAAATTATCAACTAGATAATAGT
2481 ATAGATAAATGAATTTGTAGCTAATTCTTGCTAGTTGTTGCATCCAGAGAGCTTTGAATAACATCATTAATCTACTCTTT
2561 AGCCTTGCATGGTATGCTATGAGGCTCCTGTTCTGTTCAAGTATTCTAATCAATGGCTTTGAAAAGTTTATCAAATTTAC
2641 ATACAGATCACAAGCCTAGGAGAAATAACTAATTCACAGATGACAGAATTAAGATTATAAAAGATTTTTTTTTTGTAATT
2721 TTAGTAGAGACAGGGTTGCCATTGTATTCCAGCCTTGGCGACAGAGCAAGACTCTGCCTCAAAAAAAAAAAAAAAAAGGT
2801 TTTGGCAAGCTGGAACTCTTTCTGCAAATGACTAAGATAGAAAACTGCCAAGGACAAATGAGGAGTAGTTAGATTTTGAA
2881 AATATTAATCATAGAATAGTTGTTGTATGCTAAGTCACTGACCCATATTATGTACAGCATTTCTGATCTTTACTTTGCAA
2961 GATTAGTGATACTATCCCAATACACTGCTGGAGAAATCAGAATTTGGAGAAATAAGTTGTCCAAGGCAAGAAGATAGTAA
3041 ATTATAAGTACAAGTGTAATATGGACAGTATCTAACTTGAAAAGATTTCAGGCGAAAAGAATCTGGGGTTTGCCAGTCAG
3121 TTGCTCAAAAGGTCAATGAAAACCAAATAGTGAAGCTATCAGAGAAGCTAATAAATTATAGACTGCTTGAACAGTTGTGT
3201 CCAGATTAAGGGAGATAATAGCTTTCCCACCCTACTTTGTGCAGGTCATACCTCCCCAAAGTGTTTACCTAATCAGTAGG
3281 TTCACAAACTCTTGGTCATTATAGTATATGCCTAAAATGTATGCACTTAGGAATGCTAAAAATTTAAATATGGTCTAAAG
3361 CAAATAAAAGCAAAGAGGAAAAACTTTGGACAGCGTAAAGACTAGAATAGTCTTTTAAAAAGAAAGCCAGTATATTGGTT
3441 TGAAATATAGAGATGTGTCCCAATTTCAAGTATTTTAATTGCACCTTAATGAAATTATCTATTTTCTATAGATTTTAGTA
3521 CTATTGAATGTATTACTTTACTGTTACCTGAATTTATTATAAAGTGTTTTTGAATAAATAATTCTAAAAGC
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' cgcggGUUAAUUACAGACAACUa 5'
               | :|| || |||||||| 
Target 5' tcctgCTGTTTATATCTGTTGAt 3'
970 - 992 162.00 -12.80
2
miRNA  3' cgcGGGU--UAA----UUAC-AGACAACUa 5'
             :|||  |||     :|| |||||||: 
Target 5' ttaTCCAGCATTTCTCTGTGTTCTGTTGGa 3'
1860 - 1889 136.00 -12.60
3
miRNA  3' cgCGGGUUAA--UUACAGACAACua 5'
            |:|  |||   | | ||||||  
Target 5' atGTCATATTCCCAGGGCTGTTGct 3'
1090 - 1114 131.00 -12.80
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-421 :: ATM    [ Functional MTI ]
Validation Method Luciferase reporter assay , qRT-PCR , Western blot , Other
Conditions HeLa
Location of target site 3'UTR
Tools used in this research microCOSm
Original Description (Extracted from the article) ... A signii??cant reduction (30%) in the luciferase activity of the reporter construct containing the ATM 3`UTR was observed in the presence of miR-421, whereas no changes were noted in the luciferase activity of the unmodii??ed construct (pRL) with miR-421 expression (Fig. 1C). ...

- Hu, H. Du, L. Nagabayashi, G. Seeger, R. C. et al., 2010, Proc Natl Acad Sci U S A.

Article - Hu, H. Du, L. Nagabayashi, G. Seeger, R. C. et al.
- Proc Natl Acad Sci U S A, 2010
Ataxia-telangiectasia mutated (ATM) is a high molecular weight protein serine/threonine kinase that plays a central role in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA double-strand breaks. Little is known about the regulatory mechanisms for ATM expression itself. MicroRNAs are naturally existing regulators that modulate gene expression in a sequence-specific manner. Here, we show that a human microRNA, miR-421, suppresses ATM expression by targeting the 3'-untranslated region (3'UTR) of ATM transcripts. Ectopic expression of miR-421 resulted in S-phase cell cycle checkpoint changes and an increased sensitivity to ionizing radiation, creating a cellular phenotype similar to that of cells derived from ataxia-telangiectasia (A-T) patients. Blocking the interaction between miR-421 and ATM 3'UTR with an antisense morpholino oligonucleotide rescued the defective phenotype caused by miR-421 overexpression, indicating that ATM mediates the effect of miR-421 on cell cycle checkpoint and radiosensitivity. Overexpression of the N-Myc transcription factor, an oncogene frequently amplified in neuroblastoma, induced miR-421 expression, which, in turn, down-regulated ATM expression, establishing a linear signaling pathway that may contribute to N-Myc-induced tumorigenesis in neuroblastoma. Taken together, our findings implicate a previously undescribed regulatory mechanism for ATM expression and ATM-dependent DNA damage response and provide several potential targets for treating neuroblastoma and perhaps A-T.
LinkOut: [PMID: 20080624]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-421 :: ATM    [ Functional MTI ]
Validation Method
Article - Mansour, W. Y. Bogdanova, N. V. et al.
- Radiother Oncol, 2012
BACKGROUND: Cellular and clinical sensitivity to ionizing radiation (IR) is determined by DNA double-strand breaks (DSB) repair. Here, we investigate the molecular mechanism underlying the extreme response of a head and neck tumor case (SKX) to standard radiotherapy. METHODS: Immunofluorescence (IF) was used for the assessment of DSB repair, Western blot and real-time PCR for protein and mRNA expression, respectively. RESULTS: SKX cells exhibited a pronounced radiosensitivity associated with numerous residual gamma-H2AX foci after IR. This was not associated with lacking canonical repair proteins. SKX cells did not express any ATM protein. Accordingly, immunoblotting revealed no ATM kinase activity toward substrates such as p-SMC1, p-CHK2 and p-KAP1. Sequencing of all 66 exons of ATM showed no mutation. ATM mRNA level was moderately reduced, which could be reverted by 5'-Aza-C treatment but without restoring protein levels. Importantly, we demonstrated a post-transcriptional regulation in SKX cells via 6-fold enhanced levels of miR-421, which targets the 3'-UTR of ATM mRNA. Transfection of SKX cells with either anti-miR-421 inhibitor or a microRNA-insensitive ATM vector recovered ATM expression and abrogated the hyper-radiosensitivity. CONCLUSION: This is the first report describing microRNA-mediated down-regulation of ATM leading to clinically manifest tumor radiosensitivity.
LinkOut: [PMID: 23199656]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-421 :: ATM    [ Functional MTI ]
Validation Method
Article - Shen, C. Houghton, P. J.
- Proc Natl Acad Sci U S A, 2013
The ataxia telangiectasia mutated (ATM) checkpoint is the central surveillance system that maintains genome integrity. We found that in the context of childhood sarcoma, mammalian target of rapamycin (mTOR) signaling suppresses ATM by up-regulating miRNAs targeting ATM. Pharmacological inhibition or genetic down-regulation of the mTOR pathway resulted in increase of ATM mRNA and protein both in mouse sarcoma xenografts and cultured cells. mTOR Complex 1 (mTORC1) suppresses ATM via S6K1/2 signaling pathways. microRNA-18a and microRNA-421, both of which target ATM, are positively controlled by mTOR signaling. Our findings have identified a negative feedback loop for the signaling between ATM and mTOR pathways and suggest that oncogenic growth signals may promote tumorigenesis by dampening the ATM checkpoint.
LinkOut: [PMID: 23818585]
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
223 hsa-miR-421 Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001103 RBMXL1 RNA binding motif protein, X-linked-like 1 3 1
MIRT001104 CBX7 chromobox homolog 7 3 1
MIRT003215 ATM ataxia telangiectasia mutated 4 3
MIRT006190 SMAD4 SMAD family member 4 3 1
MIRT016100 NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) 1 1
MIRT016101 SRSF7 serine/arginine-rich splicing factor 7 1 1
MIRT016102 GID8 GID complex subunit 8 homolog (S. cerevisiae) 1 1
MIRT016103 EIF3K eukaryotic translation initiation factor 3, subunit K 1 1
MIRT016104 MAPK8 mitogen-activated protein kinase 8 1 2
MIRT016105 LIMS1 LIM and senescent cell antigen-like domains 1 1 1
MIRT016106 ZNF30 zinc finger protein 30 1 1
MIRT016107 GID4 GID complex subunit 4, VID24 homolog (S. cerevisiae) 1 1
MIRT016108 DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 1 2
MIRT016109 ZNF678 zinc finger protein 678 1 1
MIRT016110 MIS18BP1 MIS18 binding protein 1 1 1
MIRT016111 NXPE3 neurexophilin and PC-esterase domain family, member 3 1 1
MIRT016112 RNF138 ring finger protein 138, E3 ubiquitin protein ligase 1 1
MIRT016113 LIN7C lin-7 homolog C (C. elegans) 1 1
MIRT016114 RGMB RGM domain family, member B 1 1
MIRT016115 SREK1IP1 SREK1-interacting protein 1 1 1
MIRT016116 TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 1 1
MIRT016117 NR6A1 nuclear receptor subfamily 6, group A, member 1 1 1
MIRT016118 CD46 CD46 molecule, complement regulatory protein 1 2
MIRT016119 NDC1 transmembrane protein 48 1 1
MIRT016120 CREBZF CREB/ATF bZIP transcription factor 1 1
MIRT016121 POLR2D polymerase (RNA) II (DNA directed) polypeptide D 1 3
MIRT016122 CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1 1
MIRT016123 FAM160B1 family with sequence similarity 160, member B1 1 2
MIRT016124 VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 1 1
MIRT016125 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 1 2
MIRT016126 CREBRF CREB3 regulatory factor 1 1
MIRT016127 FAM122A family with sequence similarity 122A 1 1
MIRT016128 DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 1 1
MIRT016129 ZFP36L2 zinc finger protein 36, C3H type-like 2 1 1
MIRT016130 RND3 Rho family GTPase 3 1 1
MIRT016131 ATG2B autophagy related 2B 1 2
MIRT016132 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT016133 RBBP7 retinoblastoma binding protein 7 1 1
MIRT016134 AFF4 AF4/FMR2 family, member 4 1 1
MIRT016135 NIPBL Nipped-B homolog (Drosophila) 1 1
MIRT039353 LMCD1 LIM and cysteine-rich domains 1 1 1
MIRT039354 RANBP2 RAN binding protein 2 1 1
MIRT039355 USO1 USO1 vesicle docking protein homolog (yeast) 1 1
MIRT039356 AP3B1 adaptor-related protein complex 3, beta 1 subunit 1 1
MIRT039357 PAXBP1 GC-rich sequence DNA-binding factor 1 1 1
MIRT039358 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1 1
MIRT039359 FAT2 FAT tumor suppressor homolog 2 (Drosophila) 1 1
MIRT039360 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 1 1
MIRT039361 GCSH glycine cleavage system protein H (aminomethyl carrier) 1 1
MIRT039362 LARS2 leucyl-tRNA synthetase 2, mitochondrial 1 1
MIRT039363 RPL18A ribosomal protein L18a 1 1
MIRT039364 EIF4A1 eukaryotic translation initiation factor 4A1 1 1
MIRT039365 DUSP3 dual specificity phosphatase 3 1 1
MIRT039366 PHKA1 phosphorylase kinase, alpha 1 (muscle) 1 1
MIRT039367 HIST2H4B histone cluster 2, H4b 1 1
MIRT039368 DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 1 1
MIRT039369 CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 1 1
MIRT039370 ACOT9 acyl-CoA thioesterase 9 1 1
MIRT039371 EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 1 1
MIRT039372 MSL3 male-specific lethal 3 homolog (Drosophila) 1 1
MIRT039373 CEP57 centrosomal protein 57kDa 1 1
MIRT039374 RPL26L1 ribosomal protein L26-like 1 1 1
MIRT039375 PCNXL4 pecanex-like 4 (Drosophila) 1 1
MIRT039376 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT039377 DOK4 docking protein 4 1 1
MIRT039378 OTUD1 OTU domain containing 1 1 1
MIRT039379 CDC42SE2 CDC42 small effector 2 1 1
MIRT039380 MRPL38 mitochondrial ribosomal protein L38 1 1
MIRT039381 ATXN2L ataxin 2-like 1 1
MIRT039382 TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 1 1
MIRT039383 GFOD2 glucose-fructose oxidoreductase domain containing 2 1 1
MIRT039384 RAB2B RAB2B, member RAS oncogene family 1 1
MIRT039385 PPP1R13B protein phosphatase 1, regulatory subunit 13B 1 1
MIRT039386 NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1 1
MIRT039387 PARP10 poly (ADP-ribose) polymerase family, member 10 1 1
MIRT039388 PQLC2 PQ loop repeat containing 2 1 1
MIRT039389 SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 1 1
MIRT039390 PRR7 proline rich 7 (synaptic) 1 1
MIRT039391 AGO1 eukaryotic translation initiation factor 2C, 1 1 1
MIRT039392 FBXO11 F-box protein 11 1 1
MIRT039393 AHNAK AHNAK nucleoprotein 1 1
MIRT039394 GRK6 G protein-coupled receptor kinase 6 1 1
MIRT039395 SLIT1 slit homolog 1 (Drosophila) 1 1
MIRT039396 SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 1 1
MIRT039397 FAM172A family with sequence similarity 172, member A 1 1
MIRT039398 SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 1 1
MIRT039399 SEPT2 septin 2 1 1
MIRT039400 CTC1 CTS telomere maintenance complex component 1 1 1
MIRT039401 CDC37 cell division cycle 37 homolog (S. cerevisiae) 1 1
MIRT039402 ZNF280C zinc finger protein 280C 1 1
MIRT039403 ISY1 ISY1 splicing factor homolog (S. cerevisiae) 1 1
MIRT039404 ZMYND8 zinc finger, MYND-type containing 8 1 1
MIRT039405 SRP9 signal recognition particle 9kDa 1 1
MIRT039406 GAREML family with sequence similarity 59, member B 1 1
MIRT039407 INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 1 1
MIRT039408 MLXIP MLX interacting protein 1 1
MIRT039409 DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 1 1
MIRT039410 FKBP8 FK506 binding protein 8, 38kDa 1 1
MIRT039411 DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 1 1
MIRT039412 COPRS chromosome 17 open reading frame 79 1 1
MIRT039413 TUBA1B tubulin, alpha 1b 1 1
MIRT039414 CASP2 caspase 2, apoptosis-related cysteine peptidase 1 1
MIRT039415 RPS18 ribosomal protein S18 1 1
MIRT039416 HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1 1
MIRT039417 COPA coatomer protein complex, subunit alpha 1 1
MIRT039418 RAB11FIP1 RAB11 family interacting protein 1 (class I) 1 1
MIRT039419 RHOB ras homolog family member B 1 1
MIRT039420 PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 1 1
MIRT039421 MCFD2 multiple coagulation factor deficiency 2 1 2
MIRT039422 CNOT1 CCR4-NOT transcription complex, subunit 1 1 1
MIRT039423 ZC3H7B zinc finger CCCH-type containing 7B 1 1
MIRT039424 AMZ2 archaelysin family metallopeptidase 2 1 1
MIRT039425 HTT huntingtin 1 1
MIRT039426 LBR lamin B receptor 1 1
MIRT039427 NCDN neurochondrin 1 1
MIRT039428 RASL10B RAS-like, family 10, member B 1 1
MIRT039429 RIF1 RAP1 interacting factor homolog (yeast) 1 1
MIRT039430 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT039431 ITPK1 inositol-tetrakisphosphate 1-kinase 1 1
MIRT039432 RPS10 ribosomal protein S10 1 1
MIRT039433 SRPR signal recognition particle receptor (docking protein) 1 1
MIRT039434 FAM168B family with sequence similarity 168, member B 1 1
MIRT039435 CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 1 1
MIRT039436 TRIM27 tripartite motif containing 27 1 1
MIRT039437 NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1 1
MIRT039438 ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 1 1
MIRT039439 ZXDA zinc finger, X-linked, duplicated A 1 1
MIRT039440 SFXN1 sideroflexin 1 1 1
MIRT039441 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 1 1
MIRT039442 RASAL1 RAS protein activator like 1 (GAP1 like) 1 1
MIRT039443 KIAA0100 KIAA0100 1 1
MIRT039444 CD276 CD276 molecule 1 1
MIRT039445 RHOBTB2 Rho-related BTB domain containing 2 1 1
MIRT039446 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1 1
MIRT039447 FAM32A family with sequence similarity 32, member A 1 1
MIRT039448 RAB26 RAB26, member RAS oncogene family 1 1
MIRT039449 TMEM109 transmembrane protein 109 1 1
MIRT039450 NCAPG non-SMC condensin I complex, subunit G 1 1
MIRT039451 PRCC papillary renal cell carcinoma (translocation-associated) 1 1
MIRT039452 PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 1 1
MIRT039453 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 1 1
MIRT039454 RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 1 1
MIRT039455 HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1 1
MIRT039456 LEPREL4 leprecan-like 4 1 1
MIRT054129 CASP3 caspase 3, apoptosis-related cysteine peptidase 2 1
MIRT077434 PNPO pyridoxamine 5'-phosphate oxidase 1 1
MIRT175554 XIAP X-linked inhibitor of apoptosis 1 3
MIRT197400 ZNF652 zinc finger protein 652 1 1
MIRT317107 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1 1
MIRT437900 FOXO4 forkhead box O4 2 1
MIRT443338 NBPF8 neuroblastoma breakpoint family, member 8 1 2
MIRT444694 GATSL2 GATS protein-like 2 1 1
MIRT453683 CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1 1
MIRT454721 MTAP methylthioadenosine phosphorylase 1 1
MIRT459440 TMEM37 transmembrane protein 37 1 1
MIRT459661 VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 1 1
MIRT461222 TM9SF1 transmembrane 9 superfamily member 1 1 1
MIRT464175 VMP1 vacuole membrane protein 1 1 10
MIRT491291 ARHGAP22 Rho GTPase activating protein 22 1 3
MIRT497007 FAM155B family with sequence similarity 155, member B 1 1
MIRT499075 CBWD1 COBW domain containing 1 1 3
MIRT499121 CBWD5 COBW domain containing 5 1 3
MIRT501521 PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 1 3
MIRT506261 PDPK1 3-phosphoinositide dependent protein kinase-1 1 1
MIRT509139 TSC22D3 TSC22 domain family, member 3 1 2
MIRT509610 GALK2 galactokinase 2 1 2
MIRT520368 UBE2D3 ubiquitin-conjugating enzyme E2D 3 1 3
MIRT526129 GJB7 gap junction protein, beta 7, 25kDa 1 1
MIRT526762 SLC6A13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 1 1
MIRT526863 PARP11 poly (ADP-ribose) polymerase family, member 11 1 1
MIRT527499 HOXA9 homeobox A9 1 3
MIRT528627 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1 1
MIRT529242 TRIM4 tripartite motif containing 4 1 2
MIRT529664 SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 1 1
MIRT532094 SYT4 synaptotagmin IV 1 1
MIRT536582 JARID2 jumonji, AT rich interactive domain 2 1 1
MIRT536726 IGF1 insulin-like growth factor 1 (somatomedin C) 1 1
MIRT540283 RGR retinal G protein coupled receptor 1 2
MIRT546178 TPRG1L tumor protein p63 regulated 1-like 1 1
MIRT550045 RSRC1 arginine/serine-rich coiled-coil 1 1 1
MIRT551685 ASB16 ankyrin repeat and SOCS box containing 16 1 1
MIRT555232 PRICKLE2 prickle homolog 2 (Drosophila) 1 1
MIRT557545 GOSR1 golgi SNAP receptor complex member 1 1 1
MIRT557637 GJD3 gap junction protein, delta 3, 31.9kDa 1 1
MIRT557698 GAS1 growth arrest-specific 1 1 2
MIRT558555 CSNK1A1 casein kinase 1, alpha 1 1 1
MIRT561410 TUBB2A tubulin, beta 2A class IIa 1 1
MIRT561663 REST RE1-silencing transcription factor 1 1
MIRT564892 YTHDF1 YTH domain family, member 1 1 1
MIRT565069 UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 1 1
MIRT565127 TXNRD1 thioredoxin reductase 1 1 1
MIRT566127 RACGAP1 Rac GTPase activating protein 1 1 1
MIRT566164 QSER1 glutamine and serine rich 1 1 1
MIRT574923 Vmp1 vacuole membrane protein 1 1 1
MIRT610052 MYBPC1 myosin binding protein C, slow type 1 1
MIRT612311 VSIG10 V-set and immunoglobulin domain containing 10 1 1
MIRT612350 TNRC6C trinucleotide repeat containing 6C 1 2
MIRT613816 RREB1 ras responsive element binding protein 1 1 2
MIRT615660 FAM89A family with sequence similarity 89, member A 1 1
MIRT621859 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1 1
MIRT623614 INTU inturned planar cell polarity effector homolog (Drosophila) 1 1
MIRT623964 FBXL16 F-box and leucine-rich repeat protein 16 1 1
MIRT626794 CSE1L CSE1 chromosome segregation 1-like (yeast) 1 1
MIRT628482 ADRBK2 adrenergic, beta, receptor kinase 2 1 2
MIRT639073 CD226 CD226 molecule 1 1
MIRT640756 TET1 tet methylcytosine dioxygenase 1 1 1
MIRT644282 ZNF208 zinc finger protein 208 1 1
MIRT649320 POLG polymerase (DNA directed), gamma 1 1
MIRT650340 TREM1 triggering receptor expressed on myeloid cells 1 1 1
MIRT655765 NPTX1 neuronal pentraxin I 1 1
MIRT655852 NFE2L1 nuclear factor (erythroid-derived 2)-like 1 1 1
MIRT656991 KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 1 1
MIRT657001 KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 1 1
MIRT689879 SOD2 superoxide dismutase 2, mitochondrial 1 1
MIRT693829 ZFP64 zinc finger protein 64 homolog (mouse) 1 1
MIRT701490 NEGR1 neuronal growth regulator 1 1 1
MIRT704508 COL4A1 collagen, type IV, alpha 1 1 1
MIRT705259 BAHD1 bromo adjacent homology domain containing 1 1 1
MIRT712569 CCDC39 coiled-coil domain containing 39 1 1
MIRT714362 BACE1 beta-site APP-cleaving enzyme 1 1 1
MIRT715493 MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 1 1
MIRT721127 TLK1 tousled-like kinase 1 1 1
MIRT721867 RHOH ras homolog family member H 1 1
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