Accession ID: MIRT003370 [miRNA, hsa-miR-18a-5p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-18aLinkOut: [miRBase ]
Synonyms MIR18, MIRN18, MIRN18A, hsa-mir-18, hsa-mir-18a, miR-18, miRNA18A, MIR18A
Description Homo sapiens miR-18a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-18 precursor-13 in reference .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-18a-5p
Mature Sequence 6| UAAGGUGCAUCUAGUGCAGAUAG |28
Evidence Experimental
Experiments Cloned
Putative hsa-miR-18a-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_000314    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_000314|3'UTR
   1 ATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGG
  81 CAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCA
 161 CAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGAC
 241 ATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGAT
 321 GTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCAC
 401 ATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACATTCT
 481 AATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATATACC
 561 ATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGTCAC
 641 TGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGGGT
 721 ACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGC
 801 AACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTA
 881 TTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAG
 961 TACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCC
1041 TGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAA
1121 GCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACATTCT
1201 ATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATACAT
1281 ATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAAAAA
1361 AAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAA
1521 TTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTG
1601 TAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGAC
1681 ATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACT
1761 AGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCA
1841 AATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCATTC
1921 AACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATTGAT
2001 TGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTCTTT
2081 CATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTTAC
2161 AATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACAT
2241 TATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCA
2321 ATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATAT
2401 AAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAA
2481 AGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTG
2561 AGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTTTAA
2641 GAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAAGGG
2721 TAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAAATG
2801 TTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGATG
2881 GCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTG
2961 TGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTC
3041 ATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCT
3121 GTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCC
3201 TCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAAC
3281 TGATTAAAGTCTCATTCTTGTCA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' gaUAGACGUGA-----UCUA-CGUGGAAu 5'
            ||: | |:|     |||| ||||:|| 
Target 5' caATTAGGATTAATAAAGATGGCACTTTc 3'
251 - 279 141.00 -9.10
2
miRNA  3' gaUAGACGUGAUC---------UACGUGGAAu 5'
            |||||:|:|:|         ||| ||||| 
Target 5' gaATCTGTATTGGGGTACAGGAATGAACCTTc 3'
705 - 736 137.00 -17.41
3
miRNA  3' gaUAGACGU--GAUCUAC-GUGGAAu 5'
            || || |  :|| ||| |||||| 
Target 5' ccAT-TGAAATTTATATGCCACCTTg 3'
2051 - 2075 130.00 -11.60
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-18a-5p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay , qRT-PCR , Western blot , Other
Conditions HCT116
Location of target site 3'UTR
Tools used in this research RNA22 , TargetScan
Original Description (Extracted from the article) ... A luciferase reporter, when fused with the wild-type human PTEN 3`UTR, was significantly repressed by overexpression of miR-19b, but not by miR-17, miR-18a,miR-20a ...

- Olive, V. Bennett, M. J. Walker, J. C. Ma, et al., 2009, Genes Dev.

Article - Olive, V. Bennett, M. J. Walker, J. C. Ma, et al.
- Genes Dev, 2009
Recent studies have revealed the importance of multiple microRNAs (miRNAs) in promoting tumorigenesis, among which mir-17-92/Oncomir-1 exhibits potent oncogenic activity. Genomic amplification and elevated expression of mir-17-92 occur in several human B-cell lymphomas, and enforced mir-17-92 expression in mice cooperates with c-myc to promote the formation of B-cell lymphomas. Unlike classic protein-coding oncogenes, mir-17-92 has an unconventional gene structure, where one primary transcript yields six individual miRNAs. Here, we functionally dissected the individual components of mir-17-92 by assaying their tumorigenic potential in vivo. Using the Emu-myc model of mouse B-cell lymphoma, we identified miR-19 as the key oncogenic component of mir-17-92, both necessary and sufficient for promoting c-myc-induced lymphomagenesis by repressing apoptosis. The oncogenic activity of miR-19 is at least in part due to its repression of the tumor suppressor Pten. Consistently, miR-19 activates the Akt-mTOR (mammalian target of rapamycin) pathway, thereby functionally antagonizing Pten to promote cell survival. Our findings reveal the essential role of miR-19 in mediating the oncogenic activity of mir-17-92, and implicate the functional diversity of mir-17-92 components as the molecular basis for its pleiotropic effects during tumorigenesis.
LinkOut: [PMID: 20008935]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-18a-5p :: PTEN    [ Functional MTI ]
Validation Method
Article - Liu, X. S. Chopp, M. Wang, X. L. Zhang, L. et al.
- J Biol Chem, 2013
The role of microRNAs (miRNAs) in mediating adult neurogenesis after stroke has not been extensively studied. The present study investigated the function of the miR17-92 cluster in adult neural progenitor cells after experimental stroke. We found that stroke substantially upregulated miR17-92 cluster expression in neural progenitor cells of the adult mouse. Overexpression of the miR17-92 cluster either in cultured ischemic neural progenitor cells or in the subventricular zone (SVZ) of ischemic animals significantly increased cell proliferation, whereas inhibition of individual members of the miR17-92 cluster, miR-18a and miR-19a, suppressed cell proliferation and increased cell death. The miR17-92 cluster mediated phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression, which is a predicted target of the miR17-92 cluster. Addition of Sonic hedgehog (Shh) protein upregulated miR17-92 expression and elevated C-MYC protein in ischemic neural progenitor cells, whereas blockade of the Shh signaling pathway downregulated miR17-92 cluster expression and reduced C-MYC levels. Over-expression of C-MYC upregulated miR17-92 cluster expression. Intraventricular infusion of Shh and a Shh receptor inhibitor, cyclopamine, to ischemic animals further elevated and suppressed, respectively, miR17-92 cluster expression in the SVZ. These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in upregulating miR17-92 cluster expression.
LinkOut: [PMID: 23511639]
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
256 hsa-miR-18a-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000703 ESR1 estrogen receptor 1 5 3
MIRT000792 IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 1 1
MIRT003370 PTEN phosphatase and tensin homolog 4 2
MIRT004174 CTGF connective tissue growth factor 4 3
MIRT004311 NCOA3 nuclear receptor coactivator 3 2 1
MIRT004383 CCNL1 cyclin L1 2 1
MIRT004384 SPPL3 signal peptide peptidase like 3 1 1
MIRT004385 CSRNP3 cysteine-serine-rich nuclear protein 3 2 1
MIRT004386 THRA thyroid hormone receptor, alpha 2 1
MIRT004387 TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3 1
MIRT004545 NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3 1
MIRT004547 TSC22D3 TSC22 domain family, member 3 3 3
MIRT004569 BCL2L11 BCL2-like 11 (apoptosis facilitator) 1 2
MIRT004587 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1 4
MIRT004592 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3 2
MIRT004665 Prmt5 protein arginine methyltransferase 5 4 1
MIRT004666 Myc myelocytomatosis oncogene 4 1
MIRT004736 SMAD4 SMAD family member 4 5 1
MIRT005361 HSF2 heat shock transcription factor 2 4 1
MIRT006118 ATM ataxia telangiectasia mutated 4 7
MIRT006613 Smad2 SMAD family member 2 3 1
MIRT006614 Smad4 SMAD family member 4 3 1
MIRT006817 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 1
MIRT006818 CDK19 cyclin-dependent kinase 19 2 1
MIRT007178 DICER1 dicer 1, ribonuclease type III 5 2
MIRT007323 SMAD3 SMAD family member 3 1 1
MIRT031310 THBS1 thrombospondin 1 1 1
MIRT031311 ZFAND5 zinc finger, AN1-type domain 5 1 1
MIRT031312 LMNB2 lamin B2 1 1
MIRT031313 FAM127B family with sequence similarity 127, member B 1 1
MIRT031314 PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1 1
MIRT031315 RAB23 RAB23, member RAS oncogene family 1 1
MIRT031316 MID1 midline 1 (Opitz/BBB syndrome) 1 1
MIRT031317 ZNF711 zinc finger protein 711 1 1
MIRT031318 MOB4 MOB family member 4, phocein 1 1
MIRT031319 SON SON DNA binding protein 1 1
MIRT031320 SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 1 1
MIRT031321 ACTL6A actin-like 6A 1 1
MIRT031322 CKAP5 cytoskeleton associated protein 5 1 1
MIRT031323 PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1 1
MIRT031324 TMUB2 transmembrane and ubiquitin-like domain containing 2 1 1
MIRT031325 NCOA6 nuclear receptor coactivator 6 1 1
MIRT031326 POGK pogo transposable element with KRAB domain 1 2
MIRT031327 KIAA0907 KIAA0907 1 1
MIRT031328 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) 1 1
MIRT031329 GABPA GA binding protein transcription factor, alpha subunit 60kDa 1 1
MIRT031330 PCNP PEST proteolytic signal containing nuclear protein 1 1
MIRT031331 HNRNPR heterogeneous nuclear ribonucleoprotein R 1 1
MIRT031332 RASSF3 Ras association (RalGDS/AF-6) domain family member 3 1 1
MIRT031333 HOXA9 homeobox A9 1 1
MIRT031334 ZNF33A zinc finger protein 33A 1 1
MIRT031335 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT031336 FEM1C fem-1 homolog c (C. elegans) 1 1
MIRT031337 ZNF708 zinc finger protein 708 1 1
MIRT031338 EZR ezrin 1 1
MIRT031339 SERTAD3 SERTA domain containing 3 1 1
MIRT031340 FAM120C family with sequence similarity 120C 1 1
MIRT031341 PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 1 1
MIRT031342 UBE2G1 ubiquitin-conjugating enzyme E2G 1 1 1
MIRT031343 UBL5 ubiquitin-like 5 1 1
MIRT031344 UBTD2 ubiquitin domain containing 2 1 1
MIRT031345 SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 1 2
MIRT031346 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 1
MIRT031347 SYPL1 synaptophysin-like 1 1 1
MIRT031348 CA12 carbonic anhydrase XII 1 2
MIRT031349 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT031350 CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 1 1
MIRT031351 RAB5A RAB5A, member RAS oncogene family 1 1
MIRT031352 PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 1 2
MIRT031353 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1 1
MIRT031354 XYLT2 xylosyltransferase II 1 1
MIRT031355 DAAM2 dishevelled associated activator of morphogenesis 2 1 1
MIRT031356 PDE4D phosphodiesterase 4D, cAMP-specific 1 2
MIRT031357 CA13 carbonic anhydrase XIII 1 1
MIRT031358 GIGYF1 GRB10 interacting GYF protein 1 1 5
MIRT031359 MAP7D1 MAP7 domain containing 1 1 1
MIRT031360 CREBL2 cAMP responsive element binding protein-like 2 1 4
MIRT050649 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 1 1
MIRT050650 ZNF703 zinc finger protein 703 1 1
MIRT050651 ZC3H18 zinc finger CCCH-type containing 18 1 1
MIRT050652 RBPJ recombination signal binding protein for immunoglobulin kappa J region 1 1
MIRT050653 DDAH1 dimethylarginine dimethylaminohydrolase 1 1 1
MIRT050654 ZSWIM6 zinc finger, SWIM-type containing 6 1 1
MIRT050655 MXD3 MAX dimerization protein 3 1 1
MIRT050656 IRS4 insulin receptor substrate 4 1 1
MIRT050657 MSL3 male-specific lethal 3 homolog (Drosophila) 1 1
MIRT050658 ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1 1
MIRT050659 AFF4 AF4/FMR2 family, member 4 1 1
MIRT050660 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT050661 PELP1 proline, glutamate and leucine rich protein 1 1 1
MIRT050662 DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 1 1
MIRT050663 PON2 paraoxonase 2 1 1
MIRT050664 TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) 1 1
MIRT050665 YBX3 cold shock domain protein A 1 1
MIRT050666 RPL9 ribosomal protein L9 1 1
MIRT050667 STX12 syntaxin 12 1 1
MIRT050668 RICTOR RPTOR independent companion of MTOR, complex 2 1 1
MIRT050669 LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1 1
MIRT050670 CIZ1 CDKN1A interacting zinc finger protein 1 1 1
MIRT050671 GCH1 GTP cyclohydrolase 1 1 1
MIRT050672 GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1 1
MIRT050673 DCAF7 DDB1 and CUL4 associated factor 7 1 3
MIRT050674 TNPO1 transportin 1 1 1
MIRT050675 ZMYND8 zinc finger, MYND-type containing 8 1 1
MIRT050676 ZFP36L2 zinc finger protein 36, C3H type-like 2 1 1
MIRT050677 MCM5 minichromosome maintenance complex component 5 1 1
MIRT050678 ERRFI1 ERBB receptor feedback inhibitor 1 1 1
MIRT050679 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT050680 IGHMBP2 immunoglobulin mu binding protein 2 1 1
MIRT050681 RPL7A ribosomal protein L7a 1 1
MIRT050682 TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 1 1
MIRT050683 TCP1 t-complex 1 1 1
MIRT050684 DIAPH1 diaphanous homolog 1 (Drosophila) 1 1
MIRT050685 CUL4A cullin 4A 1 1
MIRT050686 ZNF770 zinc finger protein 770 1 1
MIRT050687 COX7B cytochrome c oxidase subunit VIIb 1 1
MIRT050688 MATR3 matrin 3 1 1
MIRT050689 CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 1 1
MIRT050690 PPIA peptidylprolyl isomerase A (cyclophilin A) 1 1
MIRT050691 UBQLN4 ubiquilin 4 1 1
MIRT050692 CANX calnexin 1 1
MIRT050693 NBEA neurobeachin 1 1
MIRT050694 FAM104A family with sequence similarity 104, member A 1 1
MIRT050695 PI4KB phosphatidylinositol 4-kinase, catalytic, beta 1 1
MIRT050696 AHRR aryl-hydrocarbon receptor repressor 1 1
MIRT050697 MDC1 mediator of DNA-damage checkpoint 1 1 1
MIRT050698 SASS6 spindle assembly 6 homolog (C. elegans) 1 1
MIRT050699 RNF4 ring finger protein 4 1 1
MIRT050700 ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 1 1
MIRT050701 GDAP2 ganglioside induced differentiation associated protein 2 1 1
MIRT050702 CXorf40B chromosome X open reading frame 40B 1 1
MIRT050703 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1 1
MIRT050704 DCTN2 dynactin 2 (p50) 1 1
MIRT050705 RABAC1 Rab acceptor 1 (prenylated) 1 1
MIRT050706 ZMYM3 zinc finger, MYM-type 3 1 1
MIRT050707 LRRC41 leucine rich repeat containing 41 1 1
MIRT050708 CDC20 cell division cycle 20 homolog (S. cerevisiae) 1 1
MIRT050709 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT050710 UBC ubiquitin C 1 1
MIRT050711 PNPO pyridoxamine 5'-phosphate oxidase 1 1
MIRT050712 TRAPPC1 trafficking protein particle complex 1 1 1
MIRT050713 LARGE like-glycosyltransferase 1 1
MIRT050714 FAM173B family with sequence similarity 173, member B 1 1
MIRT050715 BVES blood vessel epicardial substance 1 1
MIRT050716 PDIK1L PDLIM1 interacting kinase 1 like 1 1
MIRT050717 WAC WW domain containing adaptor with coiled-coil 1 1
MIRT050718 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1 1
MIRT050719 SRSF6 serine/arginine-rich splicing factor 6 1 1
MIRT050720 PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1 1
MIRT050721 ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 1 1
MIRT050722 PCNA proliferating cell nuclear antigen 1 1
MIRT050723 SEC24B SEC24 family, member B (S. cerevisiae) 1 1
MIRT050724 HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 1 1
MIRT050725 PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 1 1
MIRT050726 KIAA0100 KIAA0100 1 1
MIRT050727 GLRX5 glutaredoxin 5 1 1
MIRT050728 ABR active BCR-related 1 1
MIRT050729 WWTR1 WW domain containing transcription regulator 1 1 1
MIRT050730 IRGQ immunity-related GTPase family, Q 1 1
MIRT050731 TCEA2 transcription elongation factor A (SII), 2 1 1
MIRT050732 CDCA5 cell division cycle associated 5 1 1
MIRT050733 ETFA electron-transfer-flavoprotein, alpha polypeptide 1 1
MIRT050734 VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1 1
MIRT050735 RNF157 ring finger protein 157 1 2
MIRT050736 TXNDC15 thioredoxin domain containing 15 1 1
MIRT050737 ORAI3 ORAI calcium release-activated calcium modulator 3 1 1
MIRT050738 B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1 1
MIRT050739 ADAM15 ADAM metallopeptidase domain 15 1 1
MIRT052968 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1 1
MIRT053024 PIAS3 protein inhibitor of activated STAT, 3 2 1
MIRT053297 BCL2 B-cell CLL/lymphoma 2 3 1
MIRT068860 UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 1 1
MIRT081709 ZNF507 zinc finger protein 507 1 1
MIRT085092 IFNAR2 interferon (alpha, beta and omega) receptor 2 1 3
MIRT087387 AGFG1 ArfGAP with FG repeats 1 1 3
MIRT090332 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1 4
MIRT091937 ZBTB47 zinc finger and BTB domain containing 47 1 3
MIRT094297 LIN54 lin-54 homolog (C. elegans) 1 2
MIRT098545 TBPL1 TBP-like 1 1 3
MIRT099596 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1 1
MIRT105324 CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 1 1
MIRT109229 VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 1 4
MIRT114158 FBXL3 F-box and leucine-rich repeat protein 3 1 1
MIRT148275 RNF138 ring finger protein 138, E3 ubiquitin protein ligase 1 1
MIRT191107 ARF6 ADP-ribosylation factor 6 1 1
MIRT194879 DCTN5 dynactin 5 (p25) 1 1
MIRT195612 FAM195A family with sequence similarity 195, member A 1 3
MIRT196599 TAOK1 TAO kinase 1 1 1
MIRT202401 RBM38 RNA binding motif protein 38 1 1
MIRT205503 SP100 SP100 nuclear antigen 1 1
MIRT207427 MRPL35 mitochondrial ribosomal protein L35 1 1
MIRT273157 RAD51AP1 RAD51 associated protein 1 1 1
MIRT282668 SYNM synemin, intermediate filament protein 1 1
MIRT302632 CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1 1
MIRT313685 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1 1
MIRT387526 SMAD2 SMAD family member 2 2 1
MIRT438457 SDC4 syndecan 4 2 1
MIRT438460 STK4 serine/threonine kinase 4 3 1
MIRT438474 BCL2L10 BCL2-like 10 (apoptosis facilitator) 1 1
MIRT438477 FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2 1
MIRT438693 NEO1 neogenin 1 2 1
MIRT438786 FAS Fas (TNF receptor superfamily, member 6) 1 1
MIRT438792 TP53 tumor protein p53 1 1
MIRT438809 DNMT1 DNA (cytosine-5-)-methyltransferase 1 1 1
MIRT442747 PTCHD1 patched domain containing 1 1 1
MIRT445126 DCAF4 DDB1 and CUL4 associated factor 4 1 1
MIRT449547 PCDH9 protocadherin 9 1 1
MIRT455222 GNL1 guanine nucleotide binding protein-like 1 1 1
MIRT455405 PLA2G2F phospholipase A2, group IIF 1 1
MIRT456069 SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1 1
MIRT456383 CRB1 crumbs homolog 1 (Drosophila) 1 1
MIRT456575 TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1 1
MIRT458082 RNLS renalase, FAD-dependent amine oxidase 1 1
MIRT464247 VCP valosin containing protein 1 1
MIRT464927 TXNIP thioredoxin interacting protein 1 2
MIRT465069 TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 1 1
MIRT469497 RDH10 retinol dehydrogenase 10 (all-trans) 1 1
MIRT470207 PSAT1 phosphoserine aminotransferase 1 1 3
MIRT472577 NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 1 1
MIRT477186 F3 coagulation factor III (thromboplastin, tissue factor) 1 3
MIRT478408 DCAF8 DDB1 and CUL4 associated factor 8 1 1
MIRT480209 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 1 1
MIRT484174 WDR82P1 WD repeat domain 82 pseudogene 1 1 4
MIRT485167 RAB5C RAB5C, member RAS oncogene family 1 4
MIRT493761 GNAS GNAS complex locus 1 2
MIRT505625 SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 1 1
MIRT512897 RAP1A RAP1A, member of RAS oncogene family 1 1
MIRT513477 ZNF132 zinc finger protein 132 1 2
MIRT515179 AHI1 Abelson helper integration site 1 1 1
MIRT517531 ITM2C integral membrane protein 2C 1 3
MIRT519502 MAPK13 mitogen-activated protein kinase 13 1 1
MIRT521853 PNISR PNN-interacting serine/arginine-rich protein 1 2
MIRT525968 ZNF585B zinc finger protein 585B 1 1
MIRT536621 IRF2 interferon regulatory factor 2 1 1
MIRT544442 ZNF460 zinc finger protein 460 1 2
MIRT546589 SAR1A SAR1 homolog A (S. cerevisiae) 1 1
MIRT546676 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 1 1
MIRT546690 RORA RAR-related orphan receptor A 1 2
MIRT546763 RLIM ring finger protein, LIM domain interacting 1 1
MIRT548289 FAM3C family with sequence similarity 3, member C 1 2
MIRT549003 CCND1 cyclin D1 1 1
MIRT551152 ZNF678 zinc finger protein 678 1 1
MIRT553232 TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila) 1 1
MIRT554719 RNF146 ring finger protein 146 1 1
MIRT563199 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 1 1
MIRT564665 ZNF367 zinc finger protein 367 1 1
MIRT571068 ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) 1 1
MIRT571091 ZNF670 zinc finger protein 670 1 1
MIRT621411 VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 1 1
MIRT629512 AS3MT arsenic (+3 oxidation state) methyltransferase 1 1
MIRT657094 JMY junction mediating and regulatory protein, p53 cofactor 1 1
MIRT662379 BDH1 3-hydroxybutyrate dehydrogenase, type 1 1 3
MIRT686806 SOX12 SRY (sex determining region Y)-box 12 1 1
MIRT690077 MBD1 methyl-CpG binding domain protein 1 1 1
MIRT698313 TMEM2 transmembrane protein 2 1 1
MIRT704016 EFCAB14 KIAA0494 1 1
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