Accession ID: MIRT003371 [miRNA, hsa-miR-19b-3p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-19b-1LinkOut: [miRBase ]
Synonyms MIRN19B1, miR-19b-1, miRNA19B1, MIR19B1
Description Homo sapiens miR-19b-1 stem-loop
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-19b-3p
Mature Sequence 54| UGUGCAAAUCCAUGCAAAACUGA |76
Evidence Experimental
Experiments Northern
Putative hsa-miR-19b-3p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_0003    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_0003|3'UTR
   1 TGAATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAA
  81 TGGCAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACAT
 161 CCACAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAG
 241 GACATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACT
 321 GATGTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTT
 401 CACATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACAT
 481 TCTAATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATAT
 561 ACCATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGT
 641 CACTGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGG
 721 GGTACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACAC
 801 AGCAACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGAT
 881 TTATTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGT
 961 TAGTACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCT
1041 GCCTGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAG
1121 TAAGCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACAT
1201 TCTATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATA
1281 CATATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAA
1361 AAAAAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTT
1521 CAATTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTA
1601 TTGTAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTT
1681 GACATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTC
1761 ACTAGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATG
1841 GCAAATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCA
1921 TTCAACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATT
2001 GATTGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTC
2081 TTTCATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGT
2161 TACAATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGA
2241 CATTATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTT
2321 TCAATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATA
2401 TATAAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACT
2481 GAAAGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCT
2561 CTGAGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTT
2641 TAAGAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAA
2721 GGGTAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAA
2801 ATGTTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACG
2881 ATGGCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAA
2961 CTGTGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTT
3041 TTCATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGT
3121 GCTGTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAAT
3201 GCCTCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAA
3281 AACTGATTAAAGTCTCATTCTTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' agUCAAAACGUACCUAAACGUGu 5'
            | |||||||  | ||||||| 
Target 5' tgAATTTTGCA--GTTTTGCACa 3'
1211 - 1231 169.00 -15.10
2
miRNA  3' agucaAAACGUACCU--AAACGUGu 5'
               ||   ||||:  ||||||| 
Target 5' tgacaTTATAATGGGCTTTTGCACt 3'
2238 - 2262 152.00 -11.40
3
miRNA  3' agucaaaacguaccuAAACGUGu 5'
                         ||||||| 
Target 5' ttcacatcctaccccTTTGCACt 3'
399 - 421 140.00 -5.60
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19b-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay , qRT-PCR , Western blot , Other
Conditions HCT116
Location of target site 3'UTR
Tools used in this research RNA22 , TargetScan
Original Description (Extracted from the article) ... A luciferase reporter, when fused with the wild-type human PTEN 3`UTR, was significantly repressed by overexpression of miR-19b, but not by miR-17, miR-18a,miR-20a ...

- Olive, V. Bennett, M. J. Walker, J. C. Ma, et al., 2009, Genes Dev.

Article - Olive, V. Bennett, M. J. Walker, J. C. Ma, et al.
- Genes Dev, 2009
Recent studies have revealed the importance of multiple microRNAs (miRNAs) in promoting tumorigenesis, among which mir-17-92/Oncomir-1 exhibits potent oncogenic activity. Genomic amplification and elevated expression of mir-17-92 occur in several human B-cell lymphomas, and enforced mir-17-92 expression in mice cooperates with c-myc to promote the formation of B-cell lymphomas. Unlike classic protein-coding oncogenes, mir-17-92 has an unconventional gene structure, where one primary transcript yields six individual miRNAs. Here, we functionally dissected the individual components of mir-17-92 by assaying their tumorigenic potential in vivo. Using the Emu-myc model of mouse B-cell lymphoma, we identified miR-19 as the key oncogenic component of mir-17-92, both necessary and sufficient for promoting c-myc-induced lymphomagenesis by repressing apoptosis. The oncogenic activity of miR-19 is at least in part due to its repression of the tumor suppressor Pten. Consistently, miR-19 activates the Akt-mTOR (mammalian target of rapamycin) pathway, thereby functionally antagonizing Pten to promote cell survival. Our findings reveal the essential role of miR-19 in mediating the oncogenic activity of mir-17-92, and implicate the functional diversity of mir-17-92 components as the molecular basis for its pleiotropic effects during tumorigenesis.
LinkOut: [PMID: 20008935]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19b-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions FL5-12
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). ...

- Mavrakis, K. J. Wolfe, A. L. Oricchio, E. et al., 2010, Nat Cell Biol.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1
miRNA  3' agUCAAAACGUACCUAAACGUGu 5'
            |||||||||  | ||||||| 
Target 5' ugAGUUUUGCA--GUUUUGCACa 3'
3 - 23
Article - Mavrakis, K. J. Wolfe, A. L. Oricchio, E. et al.
- Nat Cell Biol, 2010
MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defining its relevant target genes. Here we show that miR-19 is sufficient to promote leukaemogenesis in Notch1-induced T-cell acute lymphoblastic leukaemia (T-ALL) in vivo. In concord with the pathogenic importance of this interaction in T-ALL, we report a novel translocation that targets the 17-92 cluster and coincides with a second rearrangement that activates Notch1. To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale short hairpin RNA screen for genes whose knockdown can phenocopy miR-19. Strikingly, the results of this screen were enriched for miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). Hence, an unbiased, functional genomics approach reveals a coordinate clampdown on several regulators of phosphatidylinositol-3-OH kinase-related survival signals by the leukaemogenic miR-19.
LinkOut: [PMID: 20190740]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
254 hsa-miR-19b-3p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001164 NR3C2 nuclear receptor subfamily 3, group C, member 2 1 1
MIRT001793 BACE1 beta-site APP-cleaving enzyme 1 2 1
MIRT003371 PTEN phosphatase and tensin homolog 4 2
MIRT003780 ATXN1 ataxin 1 5 2
MIRT004064 HIPK3 homeodomain interacting protein kinase 3 2 1
MIRT004065 ARID4B AT rich interactive domain 4B (RBP1-like) 3 2
MIRT004066 MYLIP myosin regulatory light chain interacting protein 2 1
MIRT004309 ESR1 estrogen receptor 1 4 1
MIRT004310 NCOA3 nuclear receptor coactivator 3 2 1
MIRT004335 KAT2B K(lysine) acetyltransferase 2B 3 1
MIRT004336 SOCS1 suppressor of cytokine signaling 1 3 1
MIRT004523 BCL2L11 BCL2-like 11 (apoptosis facilitator) 2 2
MIRT004594 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4 3
MIRT004933 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 4 1
MIRT006476 CUL5 cullin 5 2 1
MIRT006647 TLR2 toll-like receptor 2 3 1
MIRT006742 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2 2
MIRT006743 PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 1 1
MIRT007271 CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1 1
MIRT007272 GCM1 glial cells missing homolog 1 (Drosophila) 1 1
MIRT031084 CTGF connective tissue growth factor 1 1
MIRT031085 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1 1
MIRT031086 ZNF417 zinc finger protein 417 1 1
MIRT031087 ZNF567 zinc finger protein 567 1 1
MIRT031088 MRPL19 mitochondrial ribosomal protein L19 1 1
MIRT031089 RPA2 replication protein A2, 32kDa 1 1
MIRT031090 HOXC8 homeobox C8 1 1
MIRT031091 KCTD20 potassium channel tetramerisation domain containing 20 1 1
MIRT031092 NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 1 1
MIRT031093 THOP1 thimet oligopeptidase 1 1 1
MIRT031094 SESTD1 SEC14 and spectrin domains 1 1 1
MIRT031095 DYNLL2 dynein, light chain, LC8-type 2 1 1
MIRT031096 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 1 1
MIRT031097 RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1 1
MIRT031098 RAB5B RAB5B, member RAS oncogene family 1 1
MIRT031099 HHEX hematopoietically expressed homeobox 1 1
MIRT031100 ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 1 1
MIRT031101 PALLD palladin, cytoskeletal associated protein 1 1
MIRT031102 MOSPD2 motile sperm domain containing 2 1 1
MIRT031103 ANKRD10 ankyrin repeat domain 10 1 1
MIRT031104 RAB34 RAB34, member RAS oncogene family 1 1
MIRT031105 YTHDC1 YTH domain containing 1 1 1
MIRT031106 KATNAL1 katanin p60 subunit A-like 1 1 1
MIRT031107 NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1 1
MIRT031108 ARHGAP12 Rho GTPase activating protein 12 1 1
MIRT031109 CENPN centromere protein N 1 1
MIRT031110 PRKACB protein kinase, cAMP-dependent, catalytic, beta 1 1
MIRT031111 LPGAT1 lysophosphatidylglycerol acyltransferase 1 1 1
MIRT031112 SIX4 SIX homeobox 4 1 1
MIRT031113 SLAIN1 SLAIN motif family, member 1 1 1
MIRT031114 HIPK1 homeodomain interacting protein kinase 1 1 1
MIRT031115 DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 1 1
MIRT031116 TRIM2 tripartite motif-containing 2 1 1
MIRT031117 DMXL2 Dmx-like 2 1 1
MIRT031118 CCNL1 cyclin L1 1 1
MIRT031119 SECISBP2L SECIS binding protein 2-like 1 1
MIRT031120 PATL1 protein associated with topoisomerase II homolog 1 (yeast) 1 1
MIRT031121 TES testis derived transcript (3 LIM domains) 1 1
MIRT031122 ATM ataxia telangiectasia mutated 1 1
MIRT031123 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 1 1
MIRT031124 NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1 1
MIRT031125 LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1 1
MIRT031126 SNAPIN SNAP-associated protein 1 1
MIRT031127 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1 1
MIRT031128 EGLN3 egl nine homolog 3 (C. elegans) 1 1
MIRT031129 XYLT2 xylosyltransferase II 1 1
MIRT031130 ADRM1 adhesion regulating molecule 1 1 1
MIRT031131 NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 1 1
MIRT031132 TRPC3 transient receptor potential cation channel, subfamily C, member 3 1 1
MIRT031133 SLC44A1 solute carrier family 44, member 1 1 1
MIRT031134 BAHD1 bromo adjacent homology domain containing 1 1 1
MIRT031135 SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 1 1
MIRT031136 PDZD11 PDZ domain containing 11 1 1
MIRT031137 SEC23B Sec23 homolog B (S. cerevisiae) 1 1
MIRT031138 TBC1D4 TBC1 domain family, member 4 1 1
MIRT031139 TBC1D25 TBC1 domain family, member 25 1 1
MIRT031140 HARS histidyl-tRNA synthetase 1 1
MIRT031141 COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) 1 1
MIRT031142 MAPRE3 microtubule-associated protein, RP/EB family, member 3 1 1
MIRT031143 SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 1 1
MIRT031144 CDK19 cyclin-dependent kinase 19 1 1
MIRT031145 KCTD10 potassium channel tetramerisation domain containing 10 1 1
MIRT031146 PTP4A1 protein tyrosine phosphatase type IVA, member 1 1 1
MIRT031147 MAP7 microtubule-associated protein 7 1 1
MIRT031148 CSNK1G1 casein kinase 1, gamma 1 1 1
MIRT031149 WDR33 WD repeat domain 33 1 1
MIRT031150 PDRG1 p53 and DNA-damage regulated 1 1 1
MIRT031151 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 1 1
MIRT031152 OTUD4 OTU domain containing 4 1 1
MIRT031153 ZCCHC14 zinc finger, CCHC domain containing 14 1 1
MIRT031154 DERL1 Der1-like domain family, member 1 1 1
MIRT031155 ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1 1
MIRT031156 SMAD4 SMAD family member 4 1 1
MIRT031157 TMEM9B TMEM9 domain family, member B 1 1
MIRT031158 ZMYM2 zinc finger, MYM-type 2 1 1
MIRT031159 GMEB2 glucocorticoid modulatory element binding protein 2 1 1
MIRT031160 CD46 CD46 molecule, complement regulatory protein 1 1
MIRT031161 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 1
MIRT031162 CA13 carbonic anhydrase XIII 1 1
MIRT031163 MID1IP1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) 1 1
MIRT031164 POGZ pogo transposable element with ZNF domain 1 1
MIRT031165 TRIM59 tripartite motif-containing 59 1 1
MIRT031166 ABHD5 abhydrolase domain containing 5 1 1
MIRT031167 SLC35D1 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 1 1
MIRT031168 PPP6R2 SAPS domain family, member 2 1 1
MIRT031169 PPP1R15B protein phosphatase 1, regulatory (inhibitor) subunit 15B 1 1
MIRT031170 ZNF217 zinc finger protein 217 1 1
MIRT031171 ZNF644 zinc finger protein 644 1 1
MIRT031172 FBXO28 F-box protein 28 1 1
MIRT031173 SOGA1 chromosome 20 open reading frame 117 1 1
MIRT031174 MPHOSPH9 M-phase phosphoprotein 9 1 1
MIRT031175 ZNF721 zinc finger protein 721 1 1
MIRT031176 PAPD4 PAP associated domain containing 4 1 1
MIRT031177 ZNF711 zinc finger protein 711 1 1
MIRT031178 MB21D2 chromosome 3 open reading frame 59 1 1
MIRT031179 ROR1 receptor tyrosine kinase-like orphan receptor 1 1 1
MIRT031180 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) 1 1
MIRT031181 CLIP1 CAP-GLY domain containing linker protein 1 1 1
MIRT031182 HOXA5 homeobox A5 1 1
MIRT031183 C16orf70 chromosome 16 open reading frame 70 1 1
MIRT031184 CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1 1
MIRT031185 CREB3L2 cAMP responsive element binding protein 3-like 2 1 1
MIRT031186 MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1 1
MIRT031187 FAM46A family with sequence similarity 46, member A 1 1
MIRT031188 WBP1L chromosome 10 open reading frame 26 1 1
MIRT031189 STEAP2 six transmembrane epithelial antigen of the prostate 2 1 1
MIRT031190 SON SON DNA binding protein 1 1
MIRT031191 AGO1 eukaryotic translation initiation factor 2C, 1 1 1
MIRT031192 MBNL1 muscleblind-like (Drosophila) 1 1
MIRT031193 SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1 1
MIRT031194 NFIB nuclear factor I/B 1 1
MIRT031195 LDLR low density lipoprotein receptor 1 1
MIRT031196 TMEM45A transmembrane protein 45A 1 1
MIRT031197 CEP350 centrosomal protein 350kDa 1 1
MIRT031198 TRIM33 tripartite motif-containing 33 1 1
MIRT031199 PTPRG protein tyrosine phosphatase, receptor type, G 1 1
MIRT031200 FBXO8 F-box protein 8 1 1
MIRT031201 RNF145 ring finger protein 145 1 1
MIRT031202 ZER1 zer-1 homolog (C. elegans) 1 1
MIRT031203 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT031204 SYBU syntabulin (syntaxin-interacting) 1 1
MIRT031205 ARRDC3 arrestin domain containing 3 1 1
MIRT031206 VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 1 1
MIRT031207 C11orf96 protein Ag2 homolog 1 1
MIRT031208 SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 1 1
MIRT031209 RAP2C RAP2C, member of RAS oncogene family 1 1
MIRT031210 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 1 1
MIRT031211 SLMAP sarcolemma associated protein 1 1
MIRT031212 SOCS4 suppressor of cytokine signaling 4 1 1
MIRT031213 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 1 1
MIRT031214 FYCO1 FYVE and coiled-coil domain containing 1 1 1
MIRT031215 ATMIN ATM interactor 1 1
MIRT031216 C12orf66 chromosome 12 open reading frame 66 1 1
MIRT031217 NCKAP5 NCK-associated protein 5 1 1
MIRT031218 BTBD3 BTB (POZ) domain containing 3 1 1
MIRT031219 SAMD1 sterile alpha motif domain containing 1 1 1
MIRT031220 WBP2 WW domain binding protein 2 1 1
MIRT031221 CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1 1
MIRT031222 ACPL2 acid phosphatase-like 2 1 1
MIRT031223 TBC1D13 TBC1 domain family, member 13 1 1
MIRT031224 GPATCH8 G patch domain containing 8 1 1
MIRT031225 KIAA1967 KIAA1967 1 1
MIRT031226 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1 1
MIRT031227 CD2AP CD2-associated protein 1 1
MIRT031228 SRSF7 splicing factor, arginine/serine-rich 7, 35kDa 1 1
MIRT031229 TCF4 transcription factor 4 1 1
MIRT031230 DAAM2 dishevelled associated activator of morphogenesis 2 1 1
MIRT031231 HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 1 1
MIRT031232 HEG1 HEG homolog 1 (zebrafish) 1 1
MIRT031233 DCAF8 DDB1 and CUL4 associated factor 8 1 1
MIRT031234 KLHL21 kelch-like 21 (Drosophila) 1 1
MIRT031235 HABP4 hyaluronan binding protein 4 1 1
MIRT031236 PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 1 1
MIRT031237 SPG20 spastic paraplegia 20 (Troyer syndrome) 1 1
MIRT031238 SAMD8 sterile alpha motif domain containing 8 1 1
MIRT031239 LTN1 ring finger protein 160 1 1
MIRT031240 MBOAT7 membrane bound O-acyltransferase domain containing 7 1 1
MIRT031241 RNF41 ring finger protein 41 1 1
MIRT031242 ARHGAP1 Rho GTPase activating protein 1 1 1
MIRT031243 ANKRD52 ankyrin repeat domain 52 1 1
MIRT031244 BTBD10 BTB (POZ) domain containing 10 1 1
MIRT031245 ZFAND5 zinc finger, AN1-type domain 5 1 1
MIRT031246 SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 1 1
MIRT031247 LBR lamin B receptor 1 1
MIRT031248 IER3IP1 immediate early response 3 interacting protein 1 1 1
MIRT031249 WEE1 WEE1 homolog (S. pombe) 1 1
MIRT031250 TOM1L2 target of myb1-like 2 (chicken) 1 1
MIRT031251 MEF2D myocyte enhancer factor 2D 1 1
MIRT031252 USP37 ubiquitin specific peptidase 37 1 1
MIRT031253 ACVR1 activin A receptor, type I 1 1
MIRT031254 SMYD2 SET and MYND domain containing 2 1 1
MIRT031255 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT031256 MREG melanoregulin 1 1
MIRT031257 GFOD1 glucose-fructose oxidoreductase domain containing 1 1 1
MIRT031258 SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 1 1
MIRT031259 SERINC3 serine incorporator 3 1 1
MIRT031260 RRAS2 related RAS viral (r-ras) oncogene homolog 2 1 1
MIRT031261 ESYT1 extended synaptotagmin-like protein 1 1 1
MIRT031262 EPC1 enhancer of polycomb homolog 1 (Drosophila) 1 1
MIRT031263 WDR26 WD repeat domain 26 1 1
MIRT031264 PSAP prosaposin 1 1
MIRT031265 SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 1 1
MIRT031266 JARID2 jumonji, AT rich interactive domain 2 1 1
MIRT031267 RAB1A RAB1A, member RAS oncogene family 1 1
MIRT031268 RHEBL1 Ras homolog enriched in brain like 1 1 1
MIRT031269 CREBL2 cAMP responsive element binding protein-like 2 1 1
MIRT031270 CPPED1 calcineurin-like phosphoesterase domain containing 1 1 1
MIRT031271 STK38 serine/threonine kinase 38 1 1
MIRT031272 DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 1 2
MIRT031273 SPATA2 spermatogenesis associated 2 1 1
MIRT031274 CCND2 cyclin D2 1 1
MIRT031275 CNOT6 CCR4-NOT transcription complex, subunit 6 1 1
MIRT031276 ALG2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT031277 BLCAP bladder cancer associated protein 1 1
MIRT031278 CNOT4 CCR4-NOT transcription complex, subunit 4 1 1
MIRT031279 RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1 1
MIRT031280 ARHGAP11A Rho GTPase activating protein 11A 1 1
MIRT031281 VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 1 1
MIRT031282 PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 1 1
MIRT031283 PRUNE2 prune homolog 2 (Drosophila) 1 1
MIRT031284 CPD carboxypeptidase D 1 1
MIRT031285 FAT3 FAT tumor suppressor homolog 3 (Drosophila) 1 1
MIRT031286 ZNF521 zinc finger protein 521 1 1
MIRT031287 CAMSAP1 calmodulin regulated spectrin-associated protein 1 1 1
MIRT031288 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT031289 CGN cingulin 1 1
MIRT031290 IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 1 1
MIRT031291 SHCBP1 SHC SH2-domain binding protein 1 1 1
MIRT031292 OTUD1 OTU domain containing 1 1 1
MIRT031293 LPHN2 latrophilin 2 1 1
MIRT031294 E2F8 E2F transcription factor 8 1 1
MIRT031295 TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 1 1
MIRT031296 ATXN7L1 ataxin 7-like 1 1 1
MIRT031297 ATF2 activating transcription factor 2 1 1
MIRT031298 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1 1
MIRT031299 RNF11 ring finger protein 11 1 1
MIRT031300 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 1
MIRT031301 RNF111 ring finger protein 111 1 1
MIRT031302 HBP1 HMG-box transcription factor 1 1 1
MIRT031303 KLF10 Kruppel-like factor 10 1 1
MIRT050627 AP2B1 adaptor-related protein complex 2, beta 1 subunit 1 1
MIRT050628 TPGS2 chromosome 18 open reading frame 10 1 1
MIRT050629 ZNF507 zinc finger protein 507 1 1
MIRT050630 NCBP2 nuclear cap binding protein subunit 2, 20kDa 1 1
MIRT050631 ZFHX4 zinc finger homeobox 4 1 1
MIRT050632 EIF3L eukaryotic translation initiation factor 3, subunit L 1 1
MIRT050633 ALAD aminolevulinate dehydratase 1 1
MIRT050634 MRPL32 mitochondrial ribosomal protein L32 1 1
MIRT050635 ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) 1 1
MIRT050636 DEGS1 degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) 1 1
MIRT050637 TSC22D3 TSC22 domain family, member 3 1 1
MIRT050638 TMBIM6 transmembrane BAX inhibitor motif containing 6 1 1
MIRT050639 NUTF2 nuclear transport factor 2 1 1
MIRT050640 RAB21 RAB21, member RAS oncogene family 1 1