Accession ID: MIRT003803 [miRNA, hsa-miR-26a-5p :: SMAD4, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-26a-1LinkOut: [miRBase ]
Synonyms MIR26A, MIRN26A1, MIR26A1
Description Homo sapiens miR-26a-1 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-26a-5p
Mature Sequence 10| UUCAAGUAAUCCAGGAUAGGCU |31
Evidence Experimental
Experiments Cloned
Putative hsa-miR-26a-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol SMAD4 LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms DPC4, JIP, MADH4
Description SMAD family member 4
Transcript NM_0053    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on SMAD4 LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of SMAD4
(miRNA target sites are highlighted)
>SMAD4|NM_0053|3'UTR
   1 CCTTTAGACTGAGGTCTTTTACCGTTGGGGCCCTTAACCTTATCAGGATGGTGGACTACAAAATACAATCCTGTTTATAA
  81 TCTGAAGATATATTTCACTTTTGTTCTGCTTTATCTTTTCATAAAGGGTTGAAAATGTGTTTGCTGCCTTGCTCCTAGCA
 161 GACAGAAACTGGATTAAAACAATTTTTTTTTTCCTCTTCAGAACTTGTCAGGCATGGCTCAGAGCTTGAAGATTAGGAGA
 241 AACACATTCTTATTAATTCTTCACCTGTTATGTATGAAGGAATCATTCCAGTGCTAGAAAATTTAGCCCTTTAAAACGTC
 321 TTAGAGCCTTTTATCTGCAGAACATCGATATGTATATCATTCTACAGAATAATCCAGTATTGCTGATTTTAAAGGCAGAG
 401 AAGTTCTCAAAGTTAATTCACCTATGTTATTTTGTGTACAAGTTGTTATTGTTGAACATACTTCAAAAATAATGTGCCAT
 481 GTGGGTGAGTTAATTTTACCAAGAGTAACTTTACTCTGTGTTTAAAAAGTAAGTTAATAATGTATTGTAATCTTTCATCC
 561 AAAATATTTTTTGCAAGTTATATTAGTGAAGATGGTTTCAATTCAGATTGTCTTGCAACTTCAGTTTTATTTTTGCCAAG
 641 GCAAAAAACTCTTAATCTGTGTGTATATTGAGAATCCCTTAAAATTACCAGACAAAAAAATTTAAAATTACGTTTGTTAT
 721 TCCTAGTGGATGACTGTTGATGAAGTATACTTTTCCCCTGTTAAACAGTAGTTGTATTCTTCTGTATTTCTAGGCACAAG
 801 GTTGGTTGCTAAGAAGCCTATAAGAGGAATTTCTTTTCCTTCATTCATAGGGAAAGGTTTTGTATTTTTTAAAACACTAA
 881 AAGCAGCGTCACTCTACCTAATGTCTCACTGTTCTGCAAAGGTGGCAATGCTTAAACTAAATAATGAATAAACTGAATAT
 961 TTTGGAAACTGCTAAATTCTATGTTAAATACTGTGCAGAATAATGGAAACATTACAGTTCATAATAGGTAGTTTGGATAT
1041 TTTTGTACTTGATTTGATGTGACTTTTTTTGGTATAATGTTTAAATCATGTATGTTATGATATTGTTTAAAATTCAGTTT
1121 TTGTATCTTGGGGCAAGACTGCAAACTTTTTTATATCTTTTGGTTATTCTAAGCCCTTTGCCATCAATGATCATATCAAT
1201 TGGCAGTGACTTTGTATAGAGAATTTAAGTAGAAAAGTTGCAGATGTATTGACTGTACCACAGACACAATATGTATGCTT
1281 TTTACCTAGCTGGTAGCATAAATAAAACTGAATCTCAACATACAAAGTTGAATTCTAGGTTTGATTTTTAAGATTTTTTT
1361 TTTCTTTTGCACTTTTGAGTCCAATCTCAGTGATGAGGTACCTTCTACTAAATGACAGGCAACAGCCAGTTCTATTGGGC
1441 AGCTTTGTTTTTTTCCCTCACACTCTACCGGGACTTCCCCATGGACATTGTGTATCATGTGTAGAGTTGGTTTTTTTTTT
1521 TTTTAATTTTTATTTTACTATAGCAGAAATAGACCTGATTATCTACAAGATGATAAATAGATTGTCTACAGGATAAATAG
1601 TATGAAATAAAATCAAGGATTATCTTTCAGATGTGTTTACTTTTGCCTGGAGAACTTTTAGCTATAGAAACACTTGTGTG
1681 ATGATAGTCCTCCTTATATCACCTGGAATGAACACAGCTTCTACTGCCTTGCTCAGAAGGTCTTTTAAATAGACCATCCT
1761 AGAAACCACTGAGTTTGCTTATTTCTGTGATTTAAACATAGATCTTGATCCAAGCTACATGACTTTTGTCTTTAAATAAC
1841 TTATCTACCACCTCATTTGTACTCTTGATTACTTACAAATTCTTTCAGTAAACACCTAATTTTCTTCTGTAAAAGTTTGG
1921 TGATTTAAGTTTTATTGGCAGTTTTATAAAAAGACATCTTCTCTAGAAATTGCTAACTTTAGGTCCATTTTACTGTGAAT
2001 GAGGAATAGGAGTGAGTTTTAGAATAACAGATTTTTAAAAATCCAGATGATTTGATTAAAACCTTAATCATACATTGACA
2081 TAATTCATTGCTTCTTTTTTTTGAGATATGGAGTCTTGCTGTGTTGCCCAGGCAGGAGTGCAGTGGTATGATCTCAGCTC
2161 ACTGCAACCTCTGCCTCCCGGGTTCAACTGATTCTCCTGCCTCAGCCTCCCTGGTAGCTAGGATTACAGGTGCCCGCCAC
2241 CATGCCTGGCTAACTTTTGTAGTTTTAGTAGAGACGGGGTTTTGCCTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCA
2321 AGTGATCCATCCACCTTGGCCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCACTGTCCCTGGCCTCATTGTTCCCTTTT
2401 CTACTTTAAGGAAAGTTTTCATGTTTAATCATCTGGGGAAAGTATGTGAAAAATATTTGTTAAGAAGTATCTCTTTGGAG
2481 CCAAGCCACCTGTCTTGGTTTCTTTCTACTAAGAGCCATAAAGTATAGAAATACTTCTAGTTGTTAAGTGCTTATATTTG
2561 TACCTAGATTTAGTCACACGCTTTTGAGAAAACATCTAGTATGTTATGATCAGCTATTCCTGAGAGCTTGGTTGTTAATC
2641 TATATTTCTATTTCTTAGTGGTAGTCATCTTTGATGAATAAGACTAAAGATTCTCACAGGTTTAAAATTTTATGTCTACT
2721 TTAAGGGTAAAATTATGAGGTTATGGTTCTGGGTGGGTTTTCTCTAGCTAATTCATATCTCAAAGAGTCTCAAAATGTTG
2801 AATTTCAGTGCAAGCTGAATGAGAGATGAGCCATGTACACCCACCGTAAGACCTCATTCCATGTTTGTCCAGTGCCTTTC
2881 AGTGCATTATCAAAGGGAATCCTTCATGGTGTTGCCTTTATTTTCCGGGGAGTAGATCGTGGGATATAGTCTATCTCATT
2961 TTTAATAGTTTACCGCCCCTGGTATACAAAGATAATGACAATAAATCACTGCCATATAACCTTGCTTTTTCCAGAAACAT
3041 GGCTGTTTTGTATTGCTGTAACCACTAAATAGGTTGCCTATACCATTCCTCCTGTGAACAGTGCAGATTTACAGGTTGCA
3121 TGGTCTGGCTTAAGGAGAGCCATACTTGAGACATGTGAGTAAACTGAACTCATATTAGCTGTGCTGCATTTCAGACTTAA
3201 AATCCATTTTTGTGGGGCAGGGTGTGGTGTGTAAAGGGGGGTGTTTGTAATACAAGTTGAAGGCAAAATAAAATGTCCTG
3281 TCTCCCAGATGATATACATCTTATTATTTTTAAAGTTTATTGCTAATTGTAGGAAGGTGAGTTGCAGGTATCTTTGACTA
3361 TGGTCATCTGGGGAAGGAAAATTTTACATTTTACTATTAATGCTCCTTAAGTGTCTATGGAGGTTAAAGAATAAAATGGT
3441 AAATGTTTCTGTGCCTGGTTTGATGGTAACTGGTTAATAGTTACTCACCATTTTATGCAGAGTCACATTAGTTCACACCC
3521 TTTCTGAGAGCCTTTTGGGAGAAGCAGTTTTATTCTCTGAGTGGAACAGAGTTCTTTTTGTTGATAATTTCTAGTTTGCT
3601 CCCTTCGTTATTGCCAACTTTACTGGCATTTTATTTAATGATAGCAGATTGGGAAAATGGCAAATTTAGGTTACGGAGGT
3681 AAATGAGTATATGAAAGCAATTACCTCTAAAGCCAGTTAACAATTATTTTGTAGGTGGGGTACACTCAGCTTAAAGTAAT
3761 GCATTTTTTTTTCCCGTAAAGGCAGAATCCATCTTGTTGCAGATAGCTATCTAAATAATCTCATATCCTCTTTTGCAAAG
3841 ACTACAGAGAATAGGCTATGACAATCTTGTTCAAGCCTTTCCATTTTTTTCCCTGATAACTAAGTAATTTCTTTGAACAT
3921 ACCAAGAAGTATGTAAAAAGTCCATGGCCTTATTCATCCACAAAGTGGCATCCTAGGCCCAGCCTTATCCCTAGCAGTTG
4001 TCCCAGTGCTGCTAGGTTGCTTATCTTGTTTATCTGGAATCACTGTGGAGTGAAATTTTCCACATCATCCAGAATTGCCT
4081 TATTTAAGAAGTAAAACGTTTTAATTTTTAGCCTTTTTTTGGTGGAGTTATTTAATATGTATATCAGAGGATATACTAGA
4161 TGGTAACATTTCTTTCTGTGCTTGGCTATCTTTGTGGACTTCAGGGGCTTCTAAAACAGACAGGACTGTGTTGCCTTTAC
4241 TAAATGGTCTGAGACAGCTATGGTTTTGAATTTTTAGTTTTTTTTTTTTAACCCACTTCCCCTCCTGGTCTCTTCCCTCT
4321 CTGATAATTACCATTCATATGTGAGTGTTAGTGTGCCTCCTTTTAGCATTTTCTTCTTCTCTTTCTGATTCTTCATTTCT
4401 GACTGCCTAGGCAAGGAAACCAGATAACCAAACTTACTAGAACGTTCTTTAAAACACAAGTACAAACTCTGGGACAGGAC
4481 CCAAGACACTTTCCTGTGAAGTGCTGAAAAAGACCTCATTGTATTGGCATTTGATATCAGTTTGATGTAGCTTAGAGTGC
4561 TTCCTGATTCTTGCTGAGTTTCAGGTAGTTGAGATAGAGAGAAGTGAGTCATATTCATATTTTCCCCCTTAGAATAATAT
4641 TTTGAAAGGTTTCATTGCTTCCACTTGAATGCTGCTCTTACAAAAACTGGGGTTACAAGGGTTACTAAATTAGCATCAGT
4721 AGCCAGAGGCAATACCGTTGTCTGGAGGACACCAGCAAACAACACACAACAAAGCAAAACAAACCTTGGGAAACTAAGGC
4801 CATTTGTTTTGTTTTGGTGTCCCCTTTGAAGCCCTGCCTTCTGGCCTTACTCCTGTACAGATATTTTTGACCTATAGGTG
4881 CCTTTATGAGAATTGAGGGTCTGACATCCTGCCCCAAGGAGTAGCTAAAGTAATTGCTAGTGTTTTCAGGGATTTTAACA
4961 TCAGACTGGAATGAATGAATGAAACTTTTTGTCCTTTTTTTTTCTGTTTTTTTTTTTCTAATGTAGTAAGGACTAAGGAA
5041 AACCTTTGGTGAAGACAATCATTTCTCTCTGTTGATGTGGATACTTTTCACACCGTTTATTTAAATGCTTTCTCAATAGG
5121 TCCAGAGCCAGTGTTCTTGTTCAACCTGAAAGTAATGGCTCTGGGTTGGGCCAGACAGTTGCACTCTCTAGTTTGCCCTC
5201 TGCCACAAATTTGATGTGTGACCTTTGGGCAAGTCATTTATCTTCTCTGGGCCTTAGTTGCCTCATCTGTAAAATGAGGG
5281 AGTTGGAGTAGATTAATTATTCCAGCTCTGAAATTCTAAGTGACCTTGGCTACCTTGCAGCAGTTTTGGATTTCTTCCTT
5361 ATCTTTGTTCTGCTGTTTGAGGGGGCTTTTTACTTATTTCCATGTTATTCAAAGGAGACTAGGCTTGATATTTTATTACT
5441 GTTCTTTTATGGACAAAAGGTTACATAGTATGCCCTTAAGACTTAATTTTAACCAAAGGCCTAGCACCACCTTAGGGGCT
5521 GCAATAAACACTTAACGCGCGTGCGCACGCGCGCGCGCACACACACACACACACACACACACACACACAGGTCAGAGTTT
5601 AAGGCTTTCGAGTCATGACATTCTAGCTTTTGAATTGCGTGCACACACACACGCACGCACACACTCTGGTCAGAGTTTAT
5681 TAAGGCTTTCGAGTCATGACATTATAGCTTTTGAGTTGGTGTGTGTGACACCACCCTCCTAAGTGGTGTGTGCTTGTAAT
5761 TTTTTTTTTCAGTGAAAATGGATTGAAAACCTGTTGTTAATGCTTAGTGATATTATGCTCAAAACAAGGAAATTCCCTTG
5841 AACCGTGTCAATTAAACTGGTTTATATGACTCAAGAAAACAATACCAGTAGATGATTATTAACTTTATTCTTGGCTCTTT
5921 TTAGGTCCATTTTGATTAAGTGACTTTTGGCTGGATCATTCAGAGCTCTCTTCTAGCCTACCCTTGGATGAGTACAATTA
6001 ATGAAATTCATATTTTCAAGGACCTGGGAGCCTTCCTTGGGGCTGGGTTGAGGGTGGGGGGTTGGGGAGTCCTGGTAGAG
6081 GCCAGCTTTGTGGTAGCTGGAGAGGAAGGGATGAAACCAGCTGCTGTTGCAAAGGCTGCTTGTCATTGATAGAAGGACTC
6161 ACGGGCTTGGATTGATTAAGACTAAACATGGAGTTGGCAAACTTTCTTCAAGTATTGAGTTCTGTTCAATGCATTGGACA
6241 TGTGATTTAAGGGAAAAGTGTGAATGCTTATAGATGATGAAAACCTGGTGGGCTGCAGAGCCCAGTTTAGAAGAAGTGAG
6321 TTGGGGGTTGGGGACAGATTTGGTGGTGGTATTTCCCAACTGTTTCCTCCCCTAAATTCAGAGGAATGCAGCTATGCCAG
6401 AAGCCAGAGAAGAGCCACTCGTAGCTTCTGCTTTGGGGACAACTGGTCAGTTGAAAGTCCCAGGAGTTCCTTTGTGGCTT
6481 TCTGTATACTTTTGCCTGGTTAAAGTCTGTGGCTAAAAAATAGTCGAACCTTTCTTGAGAACTCTGTAACAAAGTATGTT
6561 TTTGATTAAAAGAGAAAGCCAACTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors  Predicted by miRanda
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-26a-5p :: SMAD4    [ Functional MTI ]
Validation Method Other
Article - Morgan, M. Iaconcig, A. Muro, A. F.
- Nucleic Acids Res, 2010
The cytoplasmic polyadenylation element binding-protein (CPEB) is an RNA-binding protein that participates in translational control. CPEB2, CPEB3 and CPEB4 are paralog proteins very similar among themselves referred as the CPEB2 subfamily. To gain insight into common mechanisms of regulation of the CPEB2 subfamily transcripts, we looked for putative cis-acting elements present in the 3'-UTRs of the three paralogs. We found different families of miRNAs predicted to target all subfamily members. Most predicted target sites for these families are located in paralog positions suggesting that these putative regulatory motifs were already present in the ancestral gene. We validated target sites for miR-92 and miR-26 in the three paralogs using mutagenesis of miRNA-binding sites in reporter constructs combined with over-expression and depletion of miRNAs. Both miR-92 and miR-26 induced a decrease in Luciferase activity associated to a reduction in mRNA levels of the reporter constructs. We also showed that the endogenous miRNAs co-regulate CPEB2, CPEB3 and CPEB4 transcripts, supporting our hypothesis that these genes have a common regulatory mechanism mediated by miRNAs. We also suggest that the ancestral pattern of miRNA-binding motifs was maintained throughout the generation of highly conserved elements in each of the 3'-UTRs.
LinkOut: [PMID: 20660482]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-26a-5p :: SMAD4    [ Functional MTI ]
Validation Method Western blot
Conditions Human aortic SMCs , HEK293
Location of target site 3'UTR
Tools used in this research PicTar , TargetScan
Original Description (Extracted from the article) ... MicroRNA-26a targets the expression of SMAD-1 and SMAD-4, members of the TGF-b superfamily signaling cascade.//Compared to negative control transfected cells, SMC transfected with anti-miRNA-26a antagomiR displayed increases in the expression of both SMAD1 (2.3- to 3.5-fold-change range, P < 0.05) and SMAD4 (1.6- to 3.3-fold-change range, P < 0.05) after 72 h of serum starvation.//One day after treatment, cells deficient in miRNA-26a displayed a qualitative increase in the rate of SMAD-1 and SMAD-4 expression after TGF-b exposure (Fig. 5B). Densitometric analysis of these blots confirmed a 1.59-fold greater expression of SMAD-1 protein and a 1.16-fold greater expression of SMAD-4 protein in cells treated with 5 ng/ml of TGF-b. ...

- Leeper, N. J. Raiesdana, A. Kojima, Y. et al., 2011, Journal of cellular physiology.

Article - Leeper, N. J. Raiesdana, A. Kojima, Y. et al.
- Journal of cellular physiology, 2011
Aberrant smooth muscle cell (SMC) plasticity has been implicated in a variety of vascular disorders including atherosclerosis, restenosis, and abdominal aortic aneurysm (AAA) formation. While the pathways governing this process remain unclear, epigenetic regulation by specific microRNAs (miRNAs) has been demonstrated in SMCs. We hypothesized that additional miRNAs might play an important role in determining vascular SMC phenotype. Microarray analysis of miRNAs was performed on human aortic SMCs undergoing phenotypic switching in response to serum withdrawal, and identified 31 significantly regulated entities. We chose the highly conserved candidate miRNA-26a for additional studies. Inhibition of miRNA-26a accelerated SMC differentiation, and also promoted apoptosis, while inhibiting proliferation and migration. Overexpression of miRNA-26a blunted differentiation. As a potential mechanism, we investigated whether miRNA-26a influences TGF-beta-pathway signaling. Dual-luciferase reporter assays demonstrated enhanced SMAD signaling with miRNA-26a inhibition, and the opposite effect with miRNA-26a overexpression in transfected human cells. Furthermore, inhibition of miRNA-26a increased gene expression of SMAD-1 and SMAD-4, while overexpression inhibited SMAD-1. MicroRNA-26a was also found to be downregulated in two mouse models of AAA formation (2.5- to 3.8-fold decrease, P < 0.02) in which enhanced switching from contractile to synthetic phenotype occurs. In summary, miRNA-26a promotes vascular SMC proliferation while inhibiting cellular differentiation and apoptosis, and alters TGF-beta pathway signaling. MicroRNA-26a represents an important new regulator of SMC biology and a potential therapeutic target in AAA disease. J. Cell. Physiol. 226: 1035-1043, 2011. (c) 2010 Wiley-Liss, Inc.
LinkOut: [PMID: 20857419]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-26a-5p :: SMAD4    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions C2C12
Location of target site 3'UTR
Tools used in this research miRanda , RNAhybrid , TargetScan
Original Description (Extracted from the article) ... Transcription factors critical for the TGF-b/BMP pathway, Smad1 and Smad4, are directly targeted by miR-26a ...

- Dey, B. K. Gagan, J. Yan, Z. Dutta, A., 2012, Genes Dev.

Article - Dey, B. K. Gagan, J. Yan, Z. Dutta, A.
- Genes Dev, 2012
Multiple microRNAs are known to be induced during the differentiation of myoblasts to myotubes. Yet, experiments in animals have not provided clear evidence for the requirement of most of these microRNAs in myogenic differentiation in vivo. miR-26a is induced during skeletal muscle differentiation and is predicted to target a well-known inhibitor of differentiation, the transforming growth factor beta/bone morphogenetic protein (TGF-beta/BMP) signaling pathway. Here we show that exogenous miR-26a promotes differentiation of myoblasts, while inhibition of miR-26a by antisense oligonucleotides or by Tough-Decoys delays differentiation. miR-26a targets the transcription factors Smad1 and Smad4, critical for the TGF-beta/BMP pathway, and expression of microRNA-resistant forms of these transcription factors inhibits differentiation. Injection of antagomirs specific to miR-26a into neonatal mice derepressed both Smad expression and activity and consequently inhibited skeletal muscle differentiation. In addition, miR-26a is induced during skeletal muscle regeneration after injury. Inhibiting miR-26a in the tibialis anterior muscles through the injection of adeno-associated virus expressing a Tough-Decoy targeting miR-26a prevents Smad down-regulation and delays regeneration. These findings provide evidence for the requirement of miR-26a for skeletal muscle differentiation and regeneration in vivo.
LinkOut: [PMID: 23028144]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
181 hsa-miR-26a-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000109 HMGA2 high mobility group AT-hook 2 4 3
MIRT000110 HMGA1 high mobility group AT-hook 1 3 3
MIRT000111 CCNE2 cyclin E2 3 1
MIRT000112 CCND2 cyclin D2 3 2
MIRT001021 CDK8 cyclin-dependent kinase 8 2 2
MIRT001022 CDC6 cell division cycle 6 homolog (S. cerevisiae) 2 2
MIRT001039 LIF leukemia inhibitory factor (cholinergic differentiation factor) 1 2
MIRT001095 PTEN phosphatase and tensin homolog 3 5
MIRT001771 EZH2 enhancer of zeste homolog 2 (Drosophila) 5 9
MIRT001772 PLAG1 pleiomorphic adenoma gene 1 3 2
MIRT002315 SERBP1 SERPINE1 mRNA binding protein 1 3 3
MIRT002340 SMAD1 SMAD family member 1 3 5
MIRT003212 MAP3K2 mitogen-activated protein kinase kinase kinase 2 3 2
MIRT003213 RB1 retinoblastoma 1 5 2
MIRT003803 SMAD4 SMAD family member 4 3 3
MIRT003968 MYC v-myc myelocytomatosis viral oncogene homolog (avian) 2 2
MIRT004338 CTGF connective tissue growth factor 2 2
MIRT004339 STRADB STE20-related kinase adaptor beta 2 2
MIRT004615 IFNB1 interferon, beta 1, fibroblast 3 2
MIRT004676 GSK3B glycogen synthase kinase 3 beta 5 2
MIRT005587 CPEB2 cytoplasmic polyadenylation element binding protein 2 3 2
MIRT005588 CPEB3 cytoplasmic polyadenylation element binding protein 3 4 2
MIRT005589 CPEB4 cytoplasmic polyadenylation element binding protein 4 3 2
MIRT005751 GDAP1 ganglioside-induced differentiation-associated protein 1 3 1
MIRT005920 MTDH metadherin 3 1
MIRT006306 CDK6 cyclin-dependent kinase 6 2 1
MIRT006309 CCNE1 cyclin E1 2 1
MIRT006389 ESR1 estrogen receptor 1 1 1
MIRT006711 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2 1
MIRT006712 ARL4C ADP-ribosylation factor-like 4C 2 1
MIRT007177 E2F7 E2F transcription factor 7 1 1
MIRT007347 NOS2 nitric oxide synthase 2, inducible 2 1
MIRT007374 IL6 interleukin 6 (interferon, beta 2) 1 1
MIRT030358 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1 1
MIRT050053 HIST1H4E histone cluster 1, H4e 1 1
MIRT050054 ZNF814 zinc finger protein 814 1 1
MIRT050055 ZNF233 zinc finger protein 233 1 1
MIRT050056 ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1 1
MIRT050057 SCRN1 secernin 1 1 1
MIRT050058 NABP1 oligonucleotide/oligosaccharide-binding fold containing 2A 1 1
MIRT050059 FAM20B family with sequence similarity 20, member B 1 1
MIRT050060 ARCN1 archain 1 1 1
MIRT050061 ANO3 anoctamin 3 1 1
MIRT050062 TFAM transcription factor A, mitochondrial 1 1
MIRT050063 FER fer (fps/fes related) tyrosine kinase 1 1
MIRT050064 HIAT1 hippocampus abundant transcript 1 1 1
MIRT050065 PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 1 1
MIRT050066 SLC35B4 solute carrier family 35, member B4 1 1
MIRT050067 RASA1 RAS p21 protein activator (GTPase activating protein) 1 1 1
MIRT050068 COX1 cytochrome c oxidase subunit I 1 1
MIRT050069 MSL3 male-specific lethal 3 homolog (Drosophila) 1 1
MIRT050070 GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 1 1
MIRT050071 GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1 1
MIRT050072 DNMT1 DNA (cytosine-5-)-methyltransferase 1 1 1
MIRT050073 MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1 1
MIRT050074 UBA2 ubiquitin-like modifier activating enzyme 2 1 1
MIRT050075 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT050076 MTRF1 mitochondrial translational release factor 1 1 1
MIRT050077 WBSCR16 Williams-Beuren syndrome chromosome region 16 1 1
MIRT050078 NUAK1 NUAK family, SNF1-like kinase, 1 1 1
MIRT050079 TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 1 1
MIRT050080 PNMA2 paraneoplastic antigen MA2 1 1
MIRT050081 ACTL8 actin-like 8 1 1
MIRT050082 HSPA8 heat shock 70kDa protein 8 1 1
MIRT050083 DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 1 1
MIRT050084 TCP1 t-complex 1 1 1
MIRT050085 SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 1 1
MIRT050086 LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 1 1
MIRT050087 CAMKV CaM kinase-like vesicle-associated 1 1
MIRT050088 ALG10B asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) 1 1
MIRT050089 TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 1 1
MIRT050090 RPL13A ribosomal protein L13a 1 1
MIRT050091 AGO1 eukaryotic translation initiation factor 2C, 1 1 1
MIRT050092 TXLNG taxilin gamma 1 1
MIRT050093 RAB18 RAB18, member RAS oncogene family 1 1
MIRT050094 RPS27A ribosomal protein S27a 1 1
MIRT050095 RPS26 ribosomal protein S26 1 1
MIRT050096 PIKFYVE phosphoinositide kinase, FYVE finger containing 1 1
MIRT050097 TP53INP1 tumor protein p53 inducible nuclear protein 1 1 1
MIRT050098 ZNF703 zinc finger protein 703 1 1
MIRT050099 MTRF1L mitochondrial translational release factor 1-like 1 1
MIRT050100 ZNF506 zinc finger protein 506 1 1
MIRT050101 KCTD5 potassium channel tetramerisation domain containing 5 1 1
MIRT050102 CTC1 chromosome 17 open reading frame 68 1 1
MIRT050103 TKT transketolase 1 1
MIRT050104 LYST lysosomal trafficking regulator 1 1
MIRT050105 FAM134A family with sequence similarity 134, member A 1 1
MIRT050106 NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 1 1
MIRT050107 AURKAIP1 aurora kinase A interacting protein 1 1 1
MIRT050108 ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1 1
MIRT050109 COASY CoA synthase 1 1
MIRT050110 CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1 1
MIRT050111 COX3 cytochrome c oxidase III 1 1
MIRT050112 ELOVL6 ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) 1 1
MIRT050113 PIGT phosphatidylinositol glycan anchor biosynthesis, class T 1 1
MIRT050114 TMCC3 transmembrane and coiled-coil domain family 3 1 1
MIRT050115 ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 1 1
MIRT050116 SHC2 SHC (Src homology 2 domain containing) transforming protein 2 1 1
MIRT050117 PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1 1
MIRT050118 PTTG1 pituitary tumor-transforming 1 1 1
MIRT050119 RPS24 ribosomal protein S24 1 1
MIRT050120 SPTBN1 spectrin, beta, non-erythrocytic 1 1 1
MIRT050121 UBTF upstream binding transcription factor, RNA polymerase I 1 1
MIRT050122 BTBD3 BTB (POZ) domain containing 3 1 1
MIRT050123 AHR aryl hydrocarbon receptor 1 1
MIRT050124 EEF1B2 eukaryotic translation elongation factor 1 beta 2 1 1
MIRT050125 MRPL51 mitochondrial ribosomal protein L51 1 1
MIRT050126 SETD2 SET domain containing 2 1 1
MIRT050127 LRP6 low density lipoprotein receptor-related protein 6 1 1
MIRT050128 RHOBTB1 Rho-related BTB domain containing 1 1 1
MIRT050129 HIST1H4J histone cluster 1, H4j 1 1
MIRT050130 MYO10 myosin X 1 1
MIRT050131 ATP7B ATPase, Cu++ transporting, beta polypeptide 1 1
MIRT050132 CSRP2BP CSRP2 binding protein 1 1
MIRT050133 RBM39 RNA binding motif protein 39 1 1
MIRT050134 C14orf37 chromosome 14 open reading frame 37 1 1
MIRT050135 SFMBT1 Scm-like with four mbt domains 1 1 1
MIRT050136 KIAA1704 KIAA1704 1 1
MIRT050137 ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 1 1
MIRT050138 ADM adrenomedullin 1 1
MIRT050139 USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 1 1
MIRT050140 TTN titin 1 1
MIRT050141 HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 1 1
MIRT050142 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 1
MIRT050143 CEPT1 choline/ethanolamine phosphotransferase 1 1 1
MIRT050144 HOXC8 homeobox C8 1 1
MIRT050145 CTBP1 C-terminal binding protein 1 1 1
MIRT050146 SET SET nuclear oncogene 1 1
MIRT050147 MCM3AP minichromosome maintenance complex component 3 associated protein 1 1
MIRT050148 TPGS2 chromosome 18 open reading frame 10 1 1
MIRT050149 CA2 carbonic anhydrase II 1 1
MIRT050150 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 1 1
MIRT050151 ACTN4 actinin, alpha 4 1 1
MIRT050152 EPG5 KIAA1632 1 1
MIRT050153 OLA1 Obg-like ATPase 1 1 1
MIRT050154 RRM2 ribonucleotide reductase M2 1 1
MIRT050155 BBX bobby sox homolog (Drosophila) 1 1
MIRT050156 NUP205 nucleoporin 205kDa 1 1
MIRT050157 C6orf47 chromosome 6 open reading frame 47 1 1
MIRT050158 CFLAR CASP8 and FADD-like apoptosis regulator 1 1
MIRT050159 SEC31A SEC31 homolog A (S. cerevisiae) 1 1
MIRT050160 GLG1 golgi glycoprotein 1 1 1
MIRT050161 TBC1D16 TBC1 domain family, member 16 1 1
MIRT050162 BTBD9 BTB (POZ) domain containing 9 1 1
MIRT050163 RND2 Rho family GTPase 2 1 1
MIRT050164 TUBG1 tubulin, gamma 1 1 1
MIRT050165 AHRR aryl-hydrocarbon receptor repressor 1 1
MIRT050166 CNTD2 cyclin N-terminal domain containing 2 1 1
MIRT050167 UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 1 1
MIRT050168 CCDC43 coiled-coil domain containing 43 1 1
MIRT050169 MSH6 mutS homolog 6 (E. coli) 1 1
MIRT050170 HIST4H4 histone cluster 4, H4 1 1
MIRT050171 C17orf51 chromosome 17 open reading frame 51 1 1
MIRT050172 SLC25A30 solute carrier family 25, member 30 1 1
MIRT050173 USB1 chromosome 16 open reading frame 57 1 1
MIRT050174 MYH10 myosin, heavy chain 10, non-muscle 1 1
MIRT050175 LINS lines homolog 1 (Drosophila) 1 1
MIRT050176 UBR4 ubiquitin protein ligase E3 component n-recognin 4 1 1
MIRT050177 ZNF207 zinc finger protein 207 1 1
MIRT050178 OGT O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1 1
MIRT050179 TXNL1 thioredoxin-like 1 1 1
MIRT050180 FOXO3 forkhead box O3 1 1
MIRT050181 COPB1 coatomer protein complex, subunit beta 1 1 1
MIRT050182 FASN fatty acid synthase 1 1
MIRT050183 SARS seryl-tRNA synthetase 1 1
MIRT050184 DDB1 damage-specific DNA binding protein 1, 127kDa 1 1
MIRT050185 PPIA peptidylprolyl isomerase A (cyclophilin A) 1 1
MIRT050186 SLC35A4 solute carrier family 35, member A4 1 1
MIRT050187 TXNDC11 thioredoxin domain containing 11 1 1
MIRT050188 HIST2H2AA3 histone cluster 2, H2aa3 1 1
MIRT050189 TRAP1 TNF receptor-associated protein 1 1 1
MIRT050190 SDCBP syndecan binding protein (syntenin) 1 1
MIRT050191 ASCC2 activating signal cointegrator 1 complex subunit 2 1 1
MIRT050192 KDM5C lysine (K)-specific demethylase 5C 1 1
MIRT050193 DST dystonin 1 1
MIRT050194 CLIC4 chloride intracellular channel 4 1 1
MIRT050195 WWP2 WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT050196 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT050197 RPL13 ribosomal protein L13 1 1
MIRT050198 CNBP CCHC-type zinc finger, nucleic acid binding protein 1 1
MIRT052649 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 1 1