Accession ID: MIRT004736 [miRNA, hsa-miR-18a-5p :: SMAD4, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-18aLinkOut: [miRBase ]
Synonyms MIR18, MIRN18, MIRN18A, hsa-mir-18, hsa-mir-18a, miR-18, miRNA18A, MIR18A
Description Homo sapiens miR-18a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-18 precursor-13 in reference .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-18a-5p
Mature Sequence 6| UAAGGUGCAUCUAGUGCAGAUAG |28
Evidence Experimental
Experiments Cloned
Putative hsa-miR-18a-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol SMAD4 LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms DPC4, JIP, MADH4
Description SMAD family member 4
Transcript NM_0053    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on SMAD4 LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of SMAD4
(miRNA target sites are highlighted)
>SMAD4|NM_0053|3'UTR
   1 CCTTTAGACTGAGGTCTTTTACCGTTGGGGCCCTTAACCTTATCAGGATGGTGGACTACAAAATACAATCCTGTTTATAA
  81 TCTGAAGATATATTTCACTTTTGTTCTGCTTTATCTTTTCATAAAGGGTTGAAAATGTGTTTGCTGCCTTGCTCCTAGCA
 161 GACAGAAACTGGATTAAAACAATTTTTTTTTTCCTCTTCAGAACTTGTCAGGCATGGCTCAGAGCTTGAAGATTAGGAGA
 241 AACACATTCTTATTAATTCTTCACCTGTTATGTATGAAGGAATCATTCCAGTGCTAGAAAATTTAGCCCTTTAAAACGTC
 321 TTAGAGCCTTTTATCTGCAGAACATCGATATGTATATCATTCTACAGAATAATCCAGTATTGCTGATTTTAAAGGCAGAG
 401 AAGTTCTCAAAGTTAATTCACCTATGTTATTTTGTGTACAAGTTGTTATTGTTGAACATACTTCAAAAATAATGTGCCAT
 481 GTGGGTGAGTTAATTTTACCAAGAGTAACTTTACTCTGTGTTTAAAAAGTAAGTTAATAATGTATTGTAATCTTTCATCC
 561 AAAATATTTTTTGCAAGTTATATTAGTGAAGATGGTTTCAATTCAGATTGTCTTGCAACTTCAGTTTTATTTTTGCCAAG
 641 GCAAAAAACTCTTAATCTGTGTGTATATTGAGAATCCCTTAAAATTACCAGACAAAAAAATTTAAAATTACGTTTGTTAT
 721 TCCTAGTGGATGACTGTTGATGAAGTATACTTTTCCCCTGTTAAACAGTAGTTGTATTCTTCTGTATTTCTAGGCACAAG
 801 GTTGGTTGCTAAGAAGCCTATAAGAGGAATTTCTTTTCCTTCATTCATAGGGAAAGGTTTTGTATTTTTTAAAACACTAA
 881 AAGCAGCGTCACTCTACCTAATGTCTCACTGTTCTGCAAAGGTGGCAATGCTTAAACTAAATAATGAATAAACTGAATAT
 961 TTTGGAAACTGCTAAATTCTATGTTAAATACTGTGCAGAATAATGGAAACATTACAGTTCATAATAGGTAGTTTGGATAT
1041 TTTTGTACTTGATTTGATGTGACTTTTTTTGGTATAATGTTTAAATCATGTATGTTATGATATTGTTTAAAATTCAGTTT
1121 TTGTATCTTGGGGCAAGACTGCAAACTTTTTTATATCTTTTGGTTATTCTAAGCCCTTTGCCATCAATGATCATATCAAT
1201 TGGCAGTGACTTTGTATAGAGAATTTAAGTAGAAAAGTTGCAGATGTATTGACTGTACCACAGACACAATATGTATGCTT
1281 TTTACCTAGCTGGTAGCATAAATAAAACTGAATCTCAACATACAAAGTTGAATTCTAGGTTTGATTTTTAAGATTTTTTT
1361 TTTCTTTTGCACTTTTGAGTCCAATCTCAGTGATGAGGTACCTTCTACTAAATGACAGGCAACAGCCAGTTCTATTGGGC
1441 AGCTTTGTTTTTTTCCCTCACACTCTACCGGGACTTCCCCATGGACATTGTGTATCATGTGTAGAGTTGGTTTTTTTTTT
1521 TTTTAATTTTTATTTTACTATAGCAGAAATAGACCTGATTATCTACAAGATGATAAATAGATTGTCTACAGGATAAATAG
1601 TATGAAATAAAATCAAGGATTATCTTTCAGATGTGTTTACTTTTGCCTGGAGAACTTTTAGCTATAGAAACACTTGTGTG
1681 ATGATAGTCCTCCTTATATCACCTGGAATGAACACAGCTTCTACTGCCTTGCTCAGAAGGTCTTTTAAATAGACCATCCT
1761 AGAAACCACTGAGTTTGCTTATTTCTGTGATTTAAACATAGATCTTGATCCAAGCTACATGACTTTTGTCTTTAAATAAC
1841 TTATCTACCACCTCATTTGTACTCTTGATTACTTACAAATTCTTTCAGTAAACACCTAATTTTCTTCTGTAAAAGTTTGG
1921 TGATTTAAGTTTTATTGGCAGTTTTATAAAAAGACATCTTCTCTAGAAATTGCTAACTTTAGGTCCATTTTACTGTGAAT
2001 GAGGAATAGGAGTGAGTTTTAGAATAACAGATTTTTAAAAATCCAGATGATTTGATTAAAACCTTAATCATACATTGACA
2081 TAATTCATTGCTTCTTTTTTTTGAGATATGGAGTCTTGCTGTGTTGCCCAGGCAGGAGTGCAGTGGTATGATCTCAGCTC
2161 ACTGCAACCTCTGCCTCCCGGGTTCAACTGATTCTCCTGCCTCAGCCTCCCTGGTAGCTAGGATTACAGGTGCCCGCCAC
2241 CATGCCTGGCTAACTTTTGTAGTTTTAGTAGAGACGGGGTTTTGCCTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCA
2321 AGTGATCCATCCACCTTGGCCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCACTGTCCCTGGCCTCATTGTTCCCTTTT
2401 CTACTTTAAGGAAAGTTTTCATGTTTAATCATCTGGGGAAAGTATGTGAAAAATATTTGTTAAGAAGTATCTCTTTGGAG
2481 CCAAGCCACCTGTCTTGGTTTCTTTCTACTAAGAGCCATAAAGTATAGAAATACTTCTAGTTGTTAAGTGCTTATATTTG
2561 TACCTAGATTTAGTCACACGCTTTTGAGAAAACATCTAGTATGTTATGATCAGCTATTCCTGAGAGCTTGGTTGTTAATC
2641 TATATTTCTATTTCTTAGTGGTAGTCATCTTTGATGAATAAGACTAAAGATTCTCACAGGTTTAAAATTTTATGTCTACT
2721 TTAAGGGTAAAATTATGAGGTTATGGTTCTGGGTGGGTTTTCTCTAGCTAATTCATATCTCAAAGAGTCTCAAAATGTTG
2801 AATTTCAGTGCAAGCTGAATGAGAGATGAGCCATGTACACCCACCGTAAGACCTCATTCCATGTTTGTCCAGTGCCTTTC
2881 AGTGCATTATCAAAGGGAATCCTTCATGGTGTTGCCTTTATTTTCCGGGGAGTAGATCGTGGGATATAGTCTATCTCATT
2961 TTTAATAGTTTACCGCCCCTGGTATACAAAGATAATGACAATAAATCACTGCCATATAACCTTGCTTTTTCCAGAAACAT
3041 GGCTGTTTTGTATTGCTGTAACCACTAAATAGGTTGCCTATACCATTCCTCCTGTGAACAGTGCAGATTTACAGGTTGCA
3121 TGGTCTGGCTTAAGGAGAGCCATACTTGAGACATGTGAGTAAACTGAACTCATATTAGCTGTGCTGCATTTCAGACTTAA
3201 AATCCATTTTTGTGGGGCAGGGTGTGGTGTGTAAAGGGGGGTGTTTGTAATACAAGTTGAAGGCAAAATAAAATGTCCTG
3281 TCTCCCAGATGATATACATCTTATTATTTTTAAAGTTTATTGCTAATTGTAGGAAGGTGAGTTGCAGGTATCTTTGACTA
3361 TGGTCATCTGGGGAAGGAAAATTTTACATTTTACTATTAATGCTCCTTAAGTGTCTATGGAGGTTAAAGAATAAAATGGT
3441 AAATGTTTCTGTGCCTGGTTTGATGGTAACTGGTTAATAGTTACTCACCATTTTATGCAGAGTCACATTAGTTCACACCC
3521 TTTCTGAGAGCCTTTTGGGAGAAGCAGTTTTATTCTCTGAGTGGAACAGAGTTCTTTTTGTTGATAATTTCTAGTTTGCT
3601 CCCTTCGTTATTGCCAACTTTACTGGCATTTTATTTAATGATAGCAGATTGGGAAAATGGCAAATTTAGGTTACGGAGGT
3681 AAATGAGTATATGAAAGCAATTACCTCTAAAGCCAGTTAACAATTATTTTGTAGGTGGGGTACACTCAGCTTAAAGTAAT
3761 GCATTTTTTTTTCCCGTAAAGGCAGAATCCATCTTGTTGCAGATAGCTATCTAAATAATCTCATATCCTCTTTTGCAAAG
3841 ACTACAGAGAATAGGCTATGACAATCTTGTTCAAGCCTTTCCATTTTTTTCCCTGATAACTAAGTAATTTCTTTGAACAT
3921 ACCAAGAAGTATGTAAAAAGTCCATGGCCTTATTCATCCACAAAGTGGCATCCTAGGCCCAGCCTTATCCCTAGCAGTTG
4001 TCCCAGTGCTGCTAGGTTGCTTATCTTGTTTATCTGGAATCACTGTGGAGTGAAATTTTCCACATCATCCAGAATTGCCT
4081 TATTTAAGAAGTAAAACGTTTTAATTTTTAGCCTTTTTTTGGTGGAGTTATTTAATATGTATATCAGAGGATATACTAGA
4161 TGGTAACATTTCTTTCTGTGCTTGGCTATCTTTGTGGACTTCAGGGGCTTCTAAAACAGACAGGACTGTGTTGCCTTTAC
4241 TAAATGGTCTGAGACAGCTATGGTTTTGAATTTTTAGTTTTTTTTTTTTAACCCACTTCCCCTCCTGGTCTCTTCCCTCT
4321 CTGATAATTACCATTCATATGTGAGTGTTAGTGTGCCTCCTTTTAGCATTTTCTTCTTCTCTTTCTGATTCTTCATTTCT
4401 GACTGCCTAGGCAAGGAAACCAGATAACCAAACTTACTAGAACGTTCTTTAAAACACAAGTACAAACTCTGGGACAGGAC
4481 CCAAGACACTTTCCTGTGAAGTGCTGAAAAAGACCTCATTGTATTGGCATTTGATATCAGTTTGATGTAGCTTAGAGTGC
4561 TTCCTGATTCTTGCTGAGTTTCAGGTAGTTGAGATAGAGAGAAGTGAGTCATATTCATATTTTCCCCCTTAGAATAATAT
4641 TTTGAAAGGTTTCATTGCTTCCACTTGAATGCTGCTCTTACAAAAACTGGGGTTACAAGGGTTACTAAATTAGCATCAGT
4721 AGCCAGAGGCAATACCGTTGTCTGGAGGACACCAGCAAACAACACACAACAAAGCAAAACAAACCTTGGGAAACTAAGGC
4801 CATTTGTTTTGTTTTGGTGTCCCCTTTGAAGCCCTGCCTTCTGGCCTTACTCCTGTACAGATATTTTTGACCTATAGGTG
4881 CCTTTATGAGAATTGAGGGTCTGACATCCTGCCCCAAGGAGTAGCTAAAGTAATTGCTAGTGTTTTCAGGGATTTTAACA
4961 TCAGACTGGAATGAATGAATGAAACTTTTTGTCCTTTTTTTTTCTGTTTTTTTTTTTCTAATGTAGTAAGGACTAAGGAA
5041 AACCTTTGGTGAAGACAATCATTTCTCTCTGTTGATGTGGATACTTTTCACACCGTTTATTTAAATGCTTTCTCAATAGG
5121 TCCAGAGCCAGTGTTCTTGTTCAACCTGAAAGTAATGGCTCTGGGTTGGGCCAGACAGTTGCACTCTCTAGTTTGCCCTC
5201 TGCCACAAATTTGATGTGTGACCTTTGGGCAAGTCATTTATCTTCTCTGGGCCTTAGTTGCCTCATCTGTAAAATGAGGG
5281 AGTTGGAGTAGATTAATTATTCCAGCTCTGAAATTCTAAGTGACCTTGGCTACCTTGCAGCAGTTTTGGATTTCTTCCTT
5361 ATCTTTGTTCTGCTGTTTGAGGGGGCTTTTTACTTATTTCCATGTTATTCAAAGGAGACTAGGCTTGATATTTTATTACT
5441 GTTCTTTTATGGACAAAAGGTTACATAGTATGCCCTTAAGACTTAATTTTAACCAAAGGCCTAGCACCACCTTAGGGGCT
5521 GCAATAAACACTTAACGCGCGTGCGCACGCGCGCGCGCACACACACACACACACACACACACACACACAGGTCAGAGTTT
5601 AAGGCTTTCGAGTCATGACATTCTAGCTTTTGAATTGCGTGCACACACACACGCACGCACACACTCTGGTCAGAGTTTAT
5681 TAAGGCTTTCGAGTCATGACATTATAGCTTTTGAGTTGGTGTGTGTGACACCACCCTCCTAAGTGGTGTGTGCTTGTAAT
5761 TTTTTTTTTCAGTGAAAATGGATTGAAAACCTGTTGTTAATGCTTAGTGATATTATGCTCAAAACAAGGAAATTCCCTTG
5841 AACCGTGTCAATTAAACTGGTTTATATGACTCAAGAAAACAATACCAGTAGATGATTATTAACTTTATTCTTGGCTCTTT
5921 TTAGGTCCATTTTGATTAAGTGACTTTTGGCTGGATCATTCAGAGCTCTCTTCTAGCCTACCCTTGGATGAGTACAATTA
6001 ATGAAATTCATATTTTCAAGGACCTGGGAGCCTTCCTTGGGGCTGGGTTGAGGGTGGGGGGTTGGGGAGTCCTGGTAGAG
6081 GCCAGCTTTGTGGTAGCTGGAGAGGAAGGGATGAAACCAGCTGCTGTTGCAAAGGCTGCTTGTCATTGATAGAAGGACTC
6161 ACGGGCTTGGATTGATTAAGACTAAACATGGAGTTGGCAAACTTTCTTCAAGTATTGAGTTCTGTTCAATGCATTGGACA
6241 TGTGATTTAAGGGAAAAGTGTGAATGCTTATAGATGATGAAAACCTGGTGGGCTGCAGAGCCCAGTTTAGAAGAAGTGAG
6321 TTGGGGGTTGGGGACAGATTTGGTGGTGGTATTTCCCAACTGTTTCCTCCCCTAAATTCAGAGGAATGCAGCTATGCCAG
6401 AAGCCAGAGAAGAGCCACTCGTAGCTTCTGCTTTGGGGACAACTGGTCAGTTGAAAGTCCCAGGAGTTCCTTTGTGGCTT
6481 TCTGTATACTTTTGCCTGGTTAAAGTCTGTGGCTAAAAAATAGTCGAACCTTTCTTGAGAACTCTGTAACAAAGTATGTT
6561 TTTGATTAAAAGAGAAAGCCAACTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors  Predicted by miRanda
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-18a-5p :: SMAD4    [ Functional MTI ]
Validation Method Immunoblot , Luciferase reporter assay , Microarray , qRT-PCR , Western blot , Other
Conditions HCT 116
Disease colon carcinoma;
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... Immunoblotting revealed that Smad2 and Smad3 levels were unaffected by miR-17∼92, but Smad4 levels were appreciably lower in miR-17∼92–transduced cells ...

- Dews, M. Fox, J. L. Hultine, S. Sundaram, et al., 2010, Cancer Res.

Article - Dews, M. Fox, J. L. Hultine, S. Sundaram, et al.
- Cancer Res, 2010
c-Myc stimulates angiogenesis in tumors through mechanisms that remain incompletely understood. Recent work indicates that c-Myc upregulates the miR-17 approximately 92 microRNA cluster and downregulates the angiogenesis inhibitor thrombospondin-1, along with other members of the thrombospondin type 1 repeat superfamily. Here, we show that downregulation of the thrombospondin type 1 repeat protein clusterin in cells overexpressing c-Myc and miR-17 approximately 92 promotes angiogenesis and tumor growth. However, clusterin downregulation by miR-17 approximately 92 is indirect. It occurs as a result of reduced transforming growth factor-beta (TGFbeta) signaling caused by targeting of several regulatory components in this signaling pathway. Specifically, miR-17-5p and miR-20 reduce the expression of the type II TGFbeta receptor and miR-18 limits the expression of Smad4. Supporting these results, in human cancer cell lines, levels of the miR-17 approximately 92 primary transcript MIR17HG negatively correlate with those of many TGFbeta-induced genes that are not direct targets of miR-17 approximately 92 (e.g., clusterin and angiopoietin-like 4). Furthermore, enforced expression of miR-17 approximately 92 in MIR17HG(low) cell lines (e.g., glioblastoma) results in impaired gene activation by TGFbeta. Together, our results define a pathway in which c-Myc activation of miR-17 approximately 92 attenuates the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth.
LinkOut: [PMID: 20940405]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
168 hsa-miR-18a-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000703 ESR1 estrogen receptor 1 5 3
MIRT000792 IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 1 1
MIRT003370 PTEN phosphatase and tensin homolog 4 1
MIRT004174 CTGF connective tissue growth factor 4 3
MIRT004311 NCOA3 nuclear receptor coactivator 3 2 1
MIRT004383 CCNL1 cyclin L1 2 1
MIRT004384 SPPL3 signal peptide peptidase 3 1 1
MIRT004385 CSRNP3 cysteine-serine-rich nuclear protein 3 2 1
MIRT004386 THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) 2 1
MIRT004387 TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3 1
MIRT004545 NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3 1
MIRT004547 TSC22D3 TSC22 domain family, member 3 2 1
MIRT004569 BCL2L11 BCL2-like 11 (apoptosis facilitator) 1 2
MIRT004587 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1 2
MIRT004592 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3 2
MIRT004665 Prmt5 protein arginine methyltransferase 5 4 1
MIRT004666 Myc myelocytomatosis oncogene 4 1
MIRT004736 SMAD4 SMAD family member 4 5 1
MIRT005361 HSF2 heat shock transcription factor 2 4 1
MIRT006118 ATM ataxia telangiectasia mutated 4 3
MIRT006613 Smad2 MAD homolog 2 (Drosophila) 3 1
MIRT006614 Smad4 MAD homolog 4 (Drosophila) 3 1
MIRT006817 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 1
MIRT006818 CDK19 cyclin-dependent kinase 19 2 1
MIRT007178 DICER1 dicer 1, ribonuclease type III 5 2
MIRT007323 SMAD3 SMAD family member 3 1 1
MIRT031310 THBS1 thrombospondin 1 1 1
MIRT031311 ZFAND5 zinc finger, AN1-type domain 5 1 1
MIRT031312 LMNB2 lamin B2 1 1
MIRT031313 FAM127B family with sequence similarity 127, member B 1 1
MIRT031314 PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1 1
MIRT031315 RAB23 RAB23, member RAS oncogene family 1 1
MIRT031316 MID1 midline 1 (Opitz/BBB syndrome) 1 1
MIRT031317 ZNF711 zinc finger protein 711 1 1
MIRT031318 MOB4 MOB1, Mps One Binder kinase activator-like 3 (yeast) 1 1
MIRT031319 SON SON DNA binding protein 1 1
MIRT031320 SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 1 1
MIRT031321 ACTL6A actin-like 6A 1 1
MIRT031322 CKAP5 cytoskeleton associated protein 5 1 1
MIRT031323 PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1 1
MIRT031324 TMUB2 transmembrane and ubiquitin-like domain containing 2 1 1
MIRT031325 NCOA6 nuclear receptor coactivator 6 1 1
MIRT031326 POGK pogo transposable element with KRAB domain 1 2
MIRT031327 KIAA0907 KIAA0907 1 1
MIRT031328 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) 1 1
MIRT031329 GABPA GA binding protein transcription factor, alpha subunit 60kDa 1 1
MIRT031330 PCNP PEST proteolytic signal containing nuclear protein 1 1
MIRT031331 HNRNPR heterogeneous nuclear ribonucleoprotein R 1 1
MIRT031332 RASSF3 Ras association (RalGDS/AF-6) domain family member 3 1 1
MIRT031333 HOXA9 homeobox A9 1 1
MIRT031334 ZNF33A zinc finger protein 33A 1 1
MIRT031335 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT031336 FEM1C fem-1 homolog c (C. elegans) 1 1
MIRT031337 ZNF708 zinc finger protein 708 1 1
MIRT031338 EZR ezrin 1 1
MIRT031339 SERTAD3 SERTA domain containing 3 1 1
MIRT031340 FAM120C family with sequence similarity 120C 1 1
MIRT031341 PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 1 1
MIRT031342 UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 1 1
MIRT031343 UBL5 ubiquitin-like 5 1 1
MIRT031344 UBTD2 ubiquitin domain containing 2 1 1
MIRT031345 SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 1 1
MIRT031346 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 1
MIRT031347 SYPL1 synaptophysin-like 1 1 1
MIRT031348 CA12 carbonic anhydrase XII 1 1
MIRT031349 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT031350 CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 1 1
MIRT031351 RAB5A RAB5A, member RAS oncogene family 1 1
MIRT031352 PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 1 1
MIRT031353 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1 1
MIRT031354 XYLT2 xylosyltransferase II 1 1
MIRT031355 DAAM2 dishevelled associated activator of morphogenesis 2 1 1
MIRT031356 PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 1 1
MIRT031357 CA13 carbonic anhydrase XIII 1 1
MIRT031358 GIGYF1 GRB10 interacting GYF protein 1 1 2
MIRT031359 MAP7D1 MAP7 domain containing 1 1 1
MIRT031360 CREBL2 cAMP responsive element binding protein-like 2 1 1
MIRT050649 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 1 1
MIRT050650 ZNF703 zinc finger protein 703 1 1
MIRT050651 ZC3H18 zinc finger CCCH-type containing 18 1 1
MIRT050652 RBPJ recombination signal binding protein for immunoglobulin kappa J region 1 1
MIRT050653 DDAH1 dimethylarginine dimethylaminohydrolase 1 1 1
MIRT050654 ZSWIM6 zinc finger, SWIM-type containing 6 1 1
MIRT050655 MXD3 MAX dimerization protein 3 1 1
MIRT050656 IRS4 insulin receptor substrate 4 1 1
MIRT050657 MSL3 male-specific lethal 3 homolog (Drosophila) 1 1
MIRT050658 ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1 1
MIRT050659 AFF4 AF4/FMR2 family, member 4 1 1
MIRT050660 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT050661 PELP1 proline, glutamate and leucine rich protein 1 1 1
MIRT050662 DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 1 1
MIRT050663 PON2 paraoxonase 2 1 1
MIRT050664 TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) 1 1
MIRT050665 YBX3 cold shock domain protein A 1 1
MIRT050666 RPL9 ribosomal protein L9 1 1
MIRT050667 STX12 syntaxin 12 1 1
MIRT050668 RICTOR RPTOR independent companion of MTOR, complex 2 1 1
MIRT050669 LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1 1
MIRT050670 CIZ1 CDKN1A interacting zinc finger protein 1 1 1
MIRT050671 GCH1 GTP cyclohydrolase 1 1 1
MIRT050672 GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1 1
MIRT050673 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT050674 TNPO1 transportin 1 1 1
MIRT050675 ZMYND8 zinc finger, MYND-type containing 8 1 1
MIRT050676 ZFP36L2 zinc finger protein 36, C3H type-like 2 1 1
MIRT050677 MCM5 minichromosome maintenance complex component 5 1 1
MIRT050678 ERRFI1 ERBB receptor feedback inhibitor 1 1 1
MIRT050679 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT050680 IGHMBP2 immunoglobulin mu binding protein 2 1 1
MIRT050681 RPL7A ribosomal protein L7a 1 1
MIRT050682 TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 1 1
MIRT050683 TCP1 t-complex 1 1 1
MIRT050684 DIAPH1 diaphanous homolog 1 (Drosophila) 1 1
MIRT050685 CUL4A cullin 4A 1 1
MIRT050686 ZNF770 zinc finger protein 770 1 1
MIRT050687 COX7B cytochrome c oxidase subunit VIIb 1 1
MIRT050688 MATR3 matrin 3 1 1
MIRT050689 CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 1 1
MIRT050690 PPIA peptidylprolyl isomerase A (cyclophilin A) 1 1
MIRT050691 UBQLN4 ubiquilin 4 1 1
MIRT050692 CANX calnexin 1 1
MIRT050693 NBEA neurobeachin 1 1
MIRT050694 FAM104A family with sequence similarity 104, member A 1 1
MIRT050695 PI4KB phosphatidylinositol 4-kinase, catalytic, beta 1 1
MIRT050696 AHRR aryl-hydrocarbon receptor repressor 1 1
MIRT050697 MDC1 mediator of DNA-damage checkpoint 1 1 1
MIRT050698 SASS6 spindle assembly 6 homolog (C. elegans) 1 1
MIRT050699 RNF4 ring finger protein 4 1 1
MIRT050700 ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 1 1
MIRT050701 GDAP2 ganglioside induced differentiation associated protein 2 1 1
MIRT050702 CXorf40B chromosome X open reading frame 40B 1 1
MIRT050703 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1 1
MIRT050704 DCTN2 dynactin 2 (p50) 1 1
MIRT050705 RABAC1 Rab acceptor 1 (prenylated) 1 1
MIRT050706 ZMYM3 zinc finger, MYM-type 3 1 1
MIRT050707 LRRC41 leucine rich repeat containing 41 1 1
MIRT050708 CDC20 cell division cycle 20 homolog (S. cerevisiae) 1 1
MIRT050709 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT050710 UBC ubiquitin C 1 1
MIRT050711 PNPO pyridoxamine 5'-phosphate oxidase 1 1
MIRT050712 TRAPPC1 trafficking protein particle complex 1 1 1
MIRT050713 LARGE like-glycosyltransferase 1 1
MIRT050714 FAM173B family with sequence similarity 173, member B 1 1
MIRT050715 BVES blood vessel epicardial substance 1 1
MIRT050716 PDIK1L PDLIM1 interacting kinase 1 like 1 1
MIRT050717 WAC WW domain containing adaptor with coiled-coil 1 1
MIRT050718 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1 1
MIRT050719 SRSF6 splicing factor, arginine/serine-rich 6 1 1
MIRT050720 PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1 1
MIRT050721 ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 1 1
MIRT050722 PCNA proliferating cell nuclear antigen 1 1
MIRT050723 SEC24B SEC24 family, member B (S. cerevisiae) 1 1
MIRT050724 HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 1 1
MIRT050725 PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 1 1
MIRT050726 KIAA0100 KIAA0100 1 1
MIRT050727 GLRX5 glutaredoxin 5 1 1
MIRT050728 ABR active BCR-related gene 1 1
MIRT050729 WWTR1 WW domain containing transcription regulator 1 1 1
MIRT050730 IRGQ immunity-related GTPase family, Q 1 1
MIRT050731 TCEA2 transcription elongation factor A (SII), 2 1 1
MIRT050732 CDCA5 cell division cycle associated 5 1 1
MIRT050733 ETFA electron-transfer-flavoprotein, alpha polypeptide 1 1
MIRT050734 VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1 1
MIRT050735 RNF157 ring finger protein 157 1 1
MIRT050736 TXNDC15 thioredoxin domain containing 15 1 1
MIRT050737 ORAI3 ORAI calcium release-activated calcium modulator 3 1 1
MIRT050738 B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1 1
MIRT050739 ADAM15 ADAM metallopeptidase domain 15 1 1