Accession ID: MIRT005585 [miRNA, hsa-miR-221-3p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-221LinkOut: [miRBase ]
Synonyms MIRN221, miRNA221, mir-221, MIR221
Description Homo sapiens miR-221 stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-221-3p
Mature Sequence 65| AGCUACAUUGUCUGCUGGGUUUC |87
Evidence Experimental
Experiments Cloned
Putative hsa-miR-221-3p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_0003    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_0003|3'UTR
   1 TGAATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAA
  81 TGGCAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACAT
 161 CCACAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAG
 241 GACATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACT
 321 GATGTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTT
 401 CACATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACAT
 481 TCTAATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATAT
 561 ACCATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGT
 641 CACTGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGG
 721 GGTACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACAC
 801 AGCAACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGAT
 881 TTATTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGT
 961 TAGTACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCT
1041 GCCTGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAG
1121 TAAGCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACAT
1201 TCTATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATA
1281 CATATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAA
1361 AAAAAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTT
1521 CAATTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTA
1601 TTGTAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTT
1681 GACATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTC
1761 ACTAGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATG
1841 GCAAATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCA
1921 TTCAACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATT
2001 GATTGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTC
2081 TTTCATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGT
2161 TACAATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGA
2241 CATTATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTT
2321 TCAATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATA
2401 TATAAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACT
2481 GAAAGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCT
2561 CTGAGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTT
2641 TAAGAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAA
2721 GGGTAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAA
2801 ATGTTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACG
2881 ATGGCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAA
2961 CTGTGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTT
3041 TTCATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGT
3121 GCTGTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAAT
3201 GCCTCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAA
3281 AACTGATTAAAGTCTCATTCTTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors  Predicted by miRanda
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-221-3p :: PTEN    [ Functional MTI ]
Validation Method Flow , Immunohistochemistry , Luciferase reporter assay , qRT-PCR , Western blot
Conditions OA chondrocyte3s
Location of target site 3'UTR
Original Description (Extracted from the article) ... MiR-221 and miR-222 Directly Target PTEN and TIMP3 3'UTRs. ...

- Garofalo, M. Di Leva, G. Romano, G. Nuovo, et al., 2009, Cancer Cell.

Article - Garofalo, M. Di Leva, G. Romano, G. Nuovo, et al.
- Cancer Cell, 2009
Lung and liver cancers are among the most deadly types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor, underlining the need for development of targeted therapies. MicroRNAs represent a class of small RNAs frequently deregulated in human malignancies. We now report that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells. We show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases. Finally, we demonstrate that the MET oncogene is involved in miR-221&222 activation through the c-Jun transcription factor.
LinkOut: [PMID: 19962668]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-221-3p :: PTEN    [ Functional MTI ]
Validation Method FACS , Flow , Luciferase reporter assay , Northern blot , Western blot , Other
Conditions SGC7901 , HEK293
Location of target site 3'UTR
Tools used in this research PicTar
Original Description (Extracted from the article) ... Notably, the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN, and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype. PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222.// ...

- Chun-Zhi, Z. Lei, H. An-Ling, Z. Yan-Chao, et al., 2010, BMC Cancer.

Article - Chun-Zhi, Z. Lei, H. An-Ling, Z. Yan-Chao, et al.
- BMC Cancer, 2010
BACKGROUND: MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were discovered to induce cell growth and cell cycle progression via direct targeting of p27 and p57 in various human malignancies. However, the roles of miR-221 and miR-222 have not been reported in human gastric cancer. In this study, we examined the impact of miR-221 and miR-222 on human gastric cancer cells, and identified target genes for miR-221 and miR-222 that might mediate their biology. METHODS: The human gastric cancer cell line SGC7901 was transfected with AS-miR-221/222 or transduced with pMSCV-miR-221/222 to knockdown or restore expression of miR-221 and miR-222, respectively. The effects of miR-221 and miR-222 were then assessed by cell viability, cell cycle analysis, apoptosis, transwell, and clonogenic assay. Potential target genes were identified by Western blot and luciferase reporter assay. RESULTS: Upregulation of miR-221 and miR-222 induced the malignant phenotype of SGC7901 cells, whereas knockdown of miR-221 and miR-222 reversed this phenotype via induction of PTEN expression. In addition, knockdonwn of miR-221 and miR-222 inhibited cell growth and invasion and increased the radiosensitivity of SGC7901 cells. Notably, the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN, and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype. PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222. CONCLUSION: These results demonstrate that miR-221 and miR-222 regulate radiosensitivity, and cell growth and invasion of SGC7901 cells, possibly via direct modulation of PTEN expression. Our study suggests that inhibition of miR-221 and miR-222 might form a novel therapeutic strategy for human gastric cancer.
LinkOut: [PMID: 20618998]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-221-3p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions MG-63 , SOSP-9607
Location of target site 3'UTR
Tools used in this research miRanda , PicTar , TargetScan
Original Description (Extracted from the article) ... PTEN is a direct target of miR-221 and miR-221 reduces PTEN expression leading to activation of PTEN/Akt pathway. ...

- Zhao, G. Cai, C. Yang, T. Qiu, X. Liao, B. et al., 2013, PLoS One.

Article - Zhao, G. Cai, C. Yang, T. Qiu, X. Liao, B. et al.
- PLoS One, 2013
BACKGROUND: MicroRNAs are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional and/or translational level and are deeply involved in the pathogenesis of several types of cancers. Specifically, microRNA-221 (miR-221) is overexpressed in many human cancers, wherein accumulating evidence indicates that it functions as an oncogene. However, the function of miR-221 in human osteosarcoma has not been totally elucidated. In the present study, the effects of miR-221 on osteosarcoma and the possible mechanism by which miR-221 affected the survival, apoptosis, and cisplatin resistance of osteosarcoma were investigated. METHODOLOGY/PRINCIPAL FINDINGS: Real-time quantitative PCR analysis revealed miR-221 was significantly upregulated in osteosarcoma cell lines than in osteoblasts. Both human osteosarcoma cell lines SOSP-9607 and MG63 were transfected with miR-221 mimic or inhibitor to regulate miR-221 expression. The effects of miR-221 were then assessed by cell viability, cell cycle analysis, apoptosis assay, and cisplatin resistance assay. In both cells, upregulation of miR-221 induced cell survival and cisplatin resistance and reduced cell apoptosis. In addition, knockdown of miR-221 inhibited cell growth and cisplatin resistance and induced cell apoptosis. Potential target genes of miR-221 were predicted using bioinformatics. Moreover, luciferase reporter assay and western blot confirmed that PTEN was a direct target of miR-221. Furthermore, introduction of PTEN cDNA lacking 3'-UTR or PI3K inhibitor LY294002 abrogated miR-221-induced cisplatin resistance. Finally, both miR-221 and PTEN expression levels in osteosarcoma samples were examined by using real-time quantitative PCR and immunohistochemistry. High miR-221 expression level and inverse correlation between miR-221 and PTEN levels were revealed in osteosarcoma tissues. CONCLUSIONS/SIGNIFICANCE: These results for the first time demonstrate that upregulation of miR-221 induces the malignant phenotype of human osteosarcoma whereas knockdown of miR-221 reverses this phenotype, suggesting that miR-221 could be a potential target for osteosarcoma treatment.
LinkOut: [PMID: 23372675]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
252 hsa-miR-221-3p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000137 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 6 24
MIRT000140 BCL2L11 BCL2-like 11 (apoptosis facilitator) 2 2
MIRT000141 BMF Bcl2 modifying factor 4 1
MIRT000434 FOXO3 forkhead box O3 4 1
MIRT001780 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 5 12
MIRT001971 HOXB5 homeobox B5 1 1
MIRT002272 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 5 5
MIRT002335 TMED7 transmembrane emp24 protein transport domain containing 7 4 9
MIRT003358 DDIT4 DNA-damage-inducible transcript 4 6 2
MIRT003359 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 5 1
MIRT003360 TBK1 TANK-binding kinase 1 4 1
MIRT003361 MYBL1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 2 1
MIRT003362 DKK2 dickkopf homolog 2 (Xenopus laevis) 2 1
MIRT003363 CREBZF CREB/ATF bZIP transcription factor 2 1
MIRT003364 BRAP BRCA1 associated protein 2 1
MIRT003365 USP18 ubiquitin specific peptidase 18 2 1
MIRT003366 ARIH2 ariadne homolog 2 (Drosophila) 2 1
MIRT003367 BBC3 BCL2 binding component 3 4 3
MIRT003368 HMGXB4 HMG box domain containing 4 2 1
MIRT003452 TIMP3 TIMP metallopeptidase inhibitor 3 3 4
MIRT003757 TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2 1
MIRT004430 ICAM1 intercellular adhesion molecule 1 3 2
MIRT004484 FOS FBJ murine osteosarcoma viral oncogene homolog 4 2
MIRT004753 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 5 1
MIRT005295 NAIP NLR family, apoptosis inhibitory protein 2 1
MIRT005320 ESR1 estrogen receptor 1 4 1
MIRT005475 TICAM1 toll-like receptor adaptor molecule 1 4 1
MIRT005585 PTEN phosphatase and tensin homolog 4 3
MIRT005714 SELE selectin E 1 1
MIRT005785 TP53 tumor protein p53 1 1
MIRT005787 CORO1A coronin, actin binding protein, 1A 2 2
MIRT005789 TCEAL1 transcription elongation factor A (SII)-like 1 1 1
MIRT006018 DIRAS3 DIRAS family, GTP-binding RAS-like 3 3 1
MIRT006063 ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 3 1
MIRT006376 DICER1 dicer 1, ribonuclease type III 1 1
MIRT006841 TRPS1 trichorhinophalangeal syndrome I 4 1
MIRT006917 CERS2 LAG1 homolog, ceramide synthase 2 3 1
MIRT007377 FMR1 fragile X mental retardation 1 1 1
MIRT024137 PDIK1L PDLIM1 interacting kinase 1 like 1 1
MIRT024138 ABHD3 abhydrolase domain containing 3 1 1
MIRT024139 NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 1 1
MIRT024140 SPTSSA chromosome 14 open reading frame 147 1 1
MIRT024141 CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 1 1
MIRT024142 NR2C2AP nuclear receptor 2C2-associated protein 1 1
MIRT024143 APOL2 apolipoprotein L, 2 1 1
MIRT024144 TDRP chromosome 8 open reading frame 42 1 1
MIRT024145 GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 1 1
MIRT024146 TMEM168 transmembrane protein 168 1 1
MIRT024147 TUB tubby homolog (mouse) 1 1
MIRT024148 ZNF652 zinc finger protein 652 1 1
MIRT024149 DVL2 dishevelled, dsh homolog 2 (Drosophila) 2 1
MIRT024150 EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 1 1
MIRT024151 TNIP1 TNFAIP3 interacting protein 1 1 1
MIRT024152 KLF9 Kruppel-like factor 9 1 1
MIRT024153 TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1 1
MIRT024154 TMEM64 transmembrane protein 64 1 1
MIRT024155 GID8 chromosome 20 open reading frame 11 1 1
MIRT024156 ZNF571 zinc finger protein 571 1 1
MIRT024157 CASP3 caspase 3, apoptosis-related cysteine peptidase 1 1
MIRT024158 ATL2 atlastin GTPase 2 1 1
MIRT024159 E2F3 E2F transcription factor 3 1 1
MIRT024160 PTBP3 ROD1 regulator of differentiation 1 (S. pombe) 1 1
MIRT024161 CXorf38 chromosome X open reading frame 38 1 1
MIRT024162 ARID1A AT rich interactive domain 1A (SWI-like) 1 1
MIRT024163 NHSL1 NHS-like 1 1 1
MIRT024164 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 1 1
MIRT024165 WDR61 WD repeat domain 61 1 1
MIRT024166 TRPC3 transient receptor potential cation channel, subfamily C, member 3 1 1
MIRT024167 SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 1 1
MIRT024168 TMEM245 chromosome 9 open reading frame 5 1 1
MIRT024169 RNF20 ring finger protein 20 1 1
MIRT024170 PHF12 PHD finger protein 12 1 1
MIRT024171 WEE1 WEE1 homolog (S. pombe) 1 1
MIRT024172 NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 1 1
MIRT024173 LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 1 1
MIRT024174 NDFIP1 Nedd4 family interacting protein 1 1 1
MIRT024175 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 1 1
MIRT024176 GPR107 G protein-coupled receptor 107 1 1
MIRT024177 LHFPL2 lipoma HMGIC fusion partner-like 2 1 1
MIRT024178 STAMBP STAM binding protein 1 1
MIRT024179 HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 1 1
MIRT024180 UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 1 1
MIRT024181 ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 1 1
MIRT024182 ACSL3 acyl-CoA synthetase long-chain family member 3 1 1
MIRT024183 RNF4 ring finger protein 4 1 1
MIRT024184 ASXL3 additional sex combs like 3 (Drosophila) 1 1
MIRT024185 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1 1
MIRT024186 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1 1
MIRT024187 RNF44 ring finger protein 44 1 1
MIRT024188 LIMS1 LIM and senescent cell antigen-like domains 1 1 1
MIRT024189 ZNF275 zinc finger protein 275 1 1
MIRT024190 TMEM132B transmembrane protein 132B 1 1
MIRT024191 CCSAP chromosome 1 open reading frame 96 1 1
MIRT024192 BRD1 bromodomain containing 1 1 1
MIRT024193 AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 1 1
MIRT024194 FBXO28 F-box protein 28 1 1
MIRT024195 TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1 1
MIRT024196 PANK3 pantothenate kinase 3 1 1
MIRT024197 ZKSCAN8 zinc finger protein 192 1 1
MIRT024198 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 1 1
MIRT024199 UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 1 1
MIRT024200 MIDN midnolin 1 1
MIRT024201 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1 1
MIRT024202 ATXN1 ataxin 1 1 2
MIRT024203 POGZ pogo transposable element with ZNF domain 1 1
MIRT024204 PPP1R15B protein phosphatase 1, regulatory (inhibitor) subunit 15B 1 1
MIRT024205 HECTD2 HECT domain containing 2 1 1
MIRT024206 POU3F2 POU class 3 homeobox 2 1 1
MIRT024207 HOXC10 homeobox C10 1 1
MIRT024208 MEOX2 mesenchyme homeobox 2 2 1
MIRT024209 ZEB2 zinc finger E-box binding homeobox 2 3 1
MIRT046837 RUNDC3B RUN domain containing 3B 1 1
MIRT046838 TRAF4 TNF receptor-associated factor 4 1 1
MIRT046839 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 1
MIRT046840 C15orf40 chromosome 15 open reading frame 40 1 1
MIRT046841 RBM33 RNA binding motif protein 33 1 1
MIRT046842 CROT carnitine O-octanoyltransferase 1 1
MIRT046843 ACTB actin, beta 1 1
MIRT046844 HIST2H2AC histone cluster 2, H2ac 1 1
MIRT046845 USP28 ubiquitin specific peptidase 28 1 1
MIRT046846 PALB2 partner and localizer of BRCA2 1 1
MIRT046847 CCT3 chaperonin containing TCP1, subunit 3 (gamma) 1 1
MIRT046848 YY1 YY1 transcription factor 1 1
MIRT046849 PLP2 proteolipid protein 2 (colonic epithelium-enriched) 1 1
MIRT046850 PXN paxillin 1 1
MIRT046851 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1 1
MIRT046852 RPS24 ribosomal protein S24 1 1
MIRT046853 TSN translin 1 1
MIRT046854 HIST1H3D histone cluster 1, H3d 1 1
MIRT046855 AMMECR1L AMME chromosomal region gene 1-like 1 1
MIRT046856 PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1 1
MIRT046857 PELO pelota homolog (Drosophila) 1 1
MIRT046859 XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1 1
MIRT046860 FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) 1 1
MIRT046861 HIST2H3D histone cluster 2, H3d 1 1
MIRT046862 MTSS1L metastasis suppressor 1-like 1 1
MIRT046863 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT046864 NOP58 NOP58 ribonucleoprotein homolog (yeast) 1 1
MIRT046865 TUBA1C tubulin, alpha 1c 1 1
MIRT046866 DDAH1 dimethylarginine dimethylaminohydrolase 1 1 1
MIRT046867 TMEM248 chromosome 7 open reading frame 42 1 1
MIRT046868 RAB5C RAB5C, member RAS oncogene family 1 1
MIRT046869 RPL15 ribosomal protein L15 1 1
MIRT046870 VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 1 1
MIRT046871 LPHN2 latrophilin 2 1 1
MIRT046872 DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1 1
MIRT046873 TIAM1 T-cell lymphoma invasion and metastasis 1 1 1
MIRT046874 ASXL2 additional sex combs like 2 (Drosophila) 1 1
MIRT046875 UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 1 1
MIRT046876 B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 1 1
MIRT046877 HSPA1B heat shock 70kDa protein 1B 1 1
MIRT046878 PEX19 peroxisomal biogenesis factor 19 1 1
MIRT046879 PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 1 1
MIRT046880 AP2A1 adaptor-related protein complex 2, alpha 1 subunit 1 1
MIRT046881 KIF16B kinesin family member 16B 1 1
MIRT046882 SEPHS1 selenophosphate synthetase 1 1 1
MIRT046883 KPNA6 karyopherin alpha 6 (importin alpha 7) 1 1
MIRT046884 SF1 splicing factor 1 1 1
MIRT046885 RHOA ras homolog gene family, member A 1 1
MIRT046886 RBM39 RNA binding motif protein 39 1 1
MIRT046887 HIST1H2AE histone cluster 1, H2ae 1 1
MIRT046888 FLNA filamin A, alpha 1 1
MIRT046889 CCDC142 coiled-coil domain containing 142 1 1
MIRT046890 ZYX zyxin 1 1
MIRT046891 KLHL8 kelch-like 8 (Drosophila) 1 1
MIRT046892 TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 1 1
MIRT046893 MDFIC MyoD family inhibitor domain containing 1 1
MIRT046894 NME2 non-metastatic cells 2, protein (NM23B) expressed in 1 1
MIRT046895 EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 1 1
MIRT046896 UBC ubiquitin C 1 1
MIRT046897 UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 1 1
MIRT046898 ADD1 adducin 1 (alpha) 1 1
MIRT046899 HECTD1 HECT domain containing 1 1 1
MIRT046900 FUS fused in sarcoma 1 1
MIRT046901 CNOT1 CCR4-NOT transcription complex, subunit 1 1 1
MIRT046902 HIST1H2AC histone cluster 1, H2ac 1 1
MIRT046903 RPL21 ribosomal protein L21 1 1
MIRT046904 WDR34 WD repeat domain 34 1 1
MIRT046905 NT5DC2 5'-nucleotidase domain containing 2 1 1
MIRT046906 LRP6 low density lipoprotein receptor-related protein 6 1 1
MIRT046907 AP3B1 adaptor-related protein complex 3, beta 1 subunit 1 1
MIRT046908 EVL Enah/Vasp-like 1 1
MIRT046909 NCL nucleolin 1 1
MIRT046910 GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 1 1
MIRT046911 PEG10 paternally expressed 10 1 1
MIRT046912 ANKRD28 ankyrin repeat domain 28 1 1
MIRT046913 TMEM183A transmembrane protein 183A 1 1
MIRT046914 LDHB lactate dehydrogenase B 1 1
MIRT046915 TRIM28 tripartite motif-containing 28 1 1
MIRT046916 NUP210 nucleoporin 210kDa 1 1
MIRT046917 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 1 1
MIRT046918 PEX1 peroxisomal biogenesis factor 1 1 1
MIRT046919 MKI67 antigen identified by monoclonal antibody Ki-67 1 1
MIRT046920 SRP68 signal recognition particle 68kDa 1 1
MIRT046921 NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 1 1
MIRT046922 FARSA phenylalanyl-tRNA synthetase, alpha subunit 1 1
MIRT046923 CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1 1
MIRT046924 CLIC1 chloride intracellular channel 1 1 1
MIRT046925 UHRF1 ubiquitin-like with PHD and ring finger domains 1 1 1
MIRT046926 NFYC nuclear transcription factor Y, gamma 1 1
MIRT046927 PHF21A PHD finger protein 21A 1 1
MIRT046928 TSC22D2 TSC22 domain family, member 2 1 1
MIRT046929 PKM pyruvate kinase, muscle 1 1
MIRT046930 CENPT centromere protein T 1 1
MIRT046931 DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 1 1
MIRT046932 LAMTOR5 hepatitis B virus x interacting protein 1 1
MIRT046933 MIEN1 chromosome 17 open reading frame 37 1 1
MIRT046934 RPS7 ribosomal protein S7 1 1
MIRT046935 NABP2 oligonucleotide/oligosaccharide-binding fold containing 2B 1 1
MIRT046936 IQCE IQ motif containing E 1 1
MIRT046937 RPLP0 ribosomal protein, large, P0 1 1
MIRT046938 YOD1 YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) 1 1
MIRT046939 CDC25C cell division cycle 25 homolog C (S. pombe) 1 1
MIRT046940 TOB2 transducer of ERBB2, 2 1 1
MIRT046941 MBNL1 muscleblind-like (Drosophila) 1 1
MIRT046942 RACGAP1 Rac GTPase activating protein 1 1 1
MIRT046943 SPAG5 sperm associated antigen 5 1 1
MIRT046944 TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 1 1
MIRT046945 SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 1 1
MIRT046946 SAPCD2 chromosome 9 open reading frame 140 1 1
MIRT046947 NFYA nuclear transcription factor Y, alpha 1 1
MIRT046948 KHSRP KH-type splicing regulatory protein 1 1
MIRT046949 AMOT angiomotin 1 1
MIRT046950 POLG polymerase (DNA directed), gamma 1 1
MIRT046951 SKI v-ski sarcoma viral oncogene homolog (avian) 1 1
MIRT046952 FBN3 fibrillin 3 1 1
MIRT046953 SPRYD3 SPRY domain containing 3 1 1
MIRT046954 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT046955 BAG3 BCL2-associated athanogene 3 1 1
MIRT046956 ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 1 1
MIRT046957 PRDM16 PR domain containing 16 1 1
MIRT046958 GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 1 1
MIRT046959 UNC13B unc-13 homolog B (C. elegans) 1 1
MIRT046960 ERC1 ELKS/RAB6-interacting/CAST family member 1 1 1
MIRT046961 SF3B3 splicing factor 3b, subunit 3, 130kDa 1 1
MIRT046962 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT046963 ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 1 1
MIRT046964 PTPRF protein tyrosine phosphatase, receptor type, F 1 1
MIRT046965 SLC30A7 solute carrier family 30 (zinc transporter), member 7 1 1
MIRT046966 RBM6 RNA binding motif protein 6 1 1
MIRT046967 ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1 1
MIRT046968 CNRIP1 cannabinoid receptor interacting protein 1 1 1
MIRT046969 NUP205 nucleoporin 205kDa 1 1
MIRT046970 DENR density-regulated protein 1 1
MIRT046971 ACTG1 actin, gamma 1 1 1
MIRT046972 ZNF35 zinc finger protein 35 1 1
MIRT046973 PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1 1
MIRT046974 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 1 1
MIRT046975 CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 1 1
MIRT046976 MFN2 mitofusin 2 1 1
MIRT046977 ARHGAP42 Rho GTPase activating protein 42 1 1
MIRT046978 DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 1 1