Accession ID: MIRT005630 [miRNA, hsa-miR-19a-3p :: SMAD4, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-19aLinkOut: [miRBase ]
Synonyms MIRN19A, hsa-mir-19a, miR-19a, miRNA19A, MIR19A
Description Homo sapiens miR-19a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-19a-3p
Mature Sequence 49| UGUGCAAAUCUAUGCAAAACUGA |71
Evidence Experimental
Experiments Cloned
Putative hsa-miR-19a-3p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol SMAD4 LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms DPC4, JIP, MADH4, MYHRS
Description SMAD family member 4
Transcript NM_005359    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on SMAD4 LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of SMAD4
(miRNA target sites are highlighted)
>SMAD4|NM_005359|3'UTR
   1 CCTTTAGACTGAGGTCTTTTACCGTTGGGGCCCTTAACCTTATCAGGATGGTGGACTACAAAATACAATCCTGTTTATAA
  81 TCTGAAGATATATTTCACTTTTGTTCTGCTTTATCTTTTCATAAAGGGTTGAAAATGTGTTTGCTGCCTTGCTCCTAGCA
 161 GACAGAAACTGGATTAAAACAATTTTTTTTTTCCTCTTCAGAACTTGTCAGGCATGGCTCAGAGCTTGAAGATTAGGAGA
 241 AACACATTCTTATTAATTCTTCACCTGTTATGTATGAAGGAATCATTCCAGTGCTAGAAAATTTAGCCCTTTAAAACGTC
 321 TTAGAGCCTTTTATCTGCAGAACATCGATATGTATATCATTCTACAGAATAATCCAGTATTGCTGATTTTAAAGGCAGAG
 401 AAGTTCTCAAAGTTAATTCACCTATGTTATTTTGTGTACAAGTTGTTATTGTTGAACATACTTCAAAAATAATGTGCCAT
 481 GTGGGTGAGTTAATTTTACCAAGAGTAACTTTACTCTGTGTTTAAAAAGTAAGTTAATAATGTATTGTAATCTTTCATCC
 561 AAAATATTTTTTGCAAGTTATATTAGTGAAGATGGTTTCAATTCAGATTGTCTTGCAACTTCAGTTTTATTTTTGCCAAG
 641 GCAAAAAACTCTTAATCTGTGTGTATATTGAGAATCCCTTAAAATTACCAGACAAAAAAATTTAAAATTACGTTTGTTAT
 721 TCCTAGTGGATGACTGTTGATGAAGTATACTTTTCCCCTGTTAAACAGTAGTTGTATTCTTCTGTATTTCTAGGCACAAG
 801 GTTGGTTGCTAAGAAGCCTATAAGAGGAATTTCTTTTCCTTCATTCATAGGGAAAGGTTTTGTATTTTTTAAAACACTAA
 881 AAGCAGCGTCACTCTACCTAATGTCTCACTGTTCTGCAAAGGTGGCAATGCTTAAACTAAATAATGAATAAACTGAATAT
 961 TTTGGAAACTGCTAAATTCTATGTTAAATACTGTGCAGAATAATGGAAACATTACAGTTCATAATAGGTAGTTTGGATAT
1041 TTTTGTACTTGATTTGATGTGACTTTTTTTGGTATAATGTTTAAATCATGTATGTTATGATATTGTTTAAAATTCAGTTT
1121 TTGTATCTTGGGGCAAGACTGCAAACTTTTTTATATCTTTTGGTTATTCTAAGCCCTTTGCCATCAATGATCATATCAAT
1201 TGGCAGTGACTTTGTATAGAGAATTTAAGTAGAAAAGTTGCAGATGTATTGACTGTACCACAGACACAATATGTATGCTT
1281 TTTACCTAGCTGGTAGCATAAATAAAACTGAATCTCAACATACAAAGTTGAATTCTAGGTTTGATTTTTAAGATTTTTTT
1361 TTTCTTTTGCACTTTTGAGTCCAATCTCAGTGATGAGGTACCTTCTACTAAATGACAGGCAACAGCCAGTTCTATTGGGC
1441 AGCTTTGTTTTTTTCCCTCACACTCTACCGGGACTTCCCCATGGACATTGTGTATCATGTGTAGAGTTGGTTTTTTTTTT
1521 TTTTAATTTTTATTTTACTATAGCAGAAATAGACCTGATTATCTACAAGATGATAAATAGATTGTCTACAGGATAAATAG
1601 TATGAAATAAAATCAAGGATTATCTTTCAGATGTGTTTACTTTTGCCTGGAGAACTTTTAGCTATAGAAACACTTGTGTG
1681 ATGATAGTCCTCCTTATATCACCTGGAATGAACACAGCTTCTACTGCCTTGCTCAGAAGGTCTTTTAAATAGACCATCCT
1761 AGAAACCACTGAGTTTGCTTATTTCTGTGATTTAAACATAGATCTTGATCCAAGCTACATGACTTTTGTCTTTAAATAAC
1841 TTATCTACCACCTCATTTGTACTCTTGATTACTTACAAATTCTTTCAGTAAACACCTAATTTTCTTCTGTAAAAGTTTGG
1921 TGATTTAAGTTTTATTGGCAGTTTTATAAAAAGACATCTTCTCTAGAAATTGCTAACTTTAGGTCCATTTTACTGTGAAT
2001 GAGGAATAGGAGTGAGTTTTAGAATAACAGATTTTTAAAAATCCAGATGATTTGATTAAAACCTTAATCATACATTGACA
2081 TAATTCATTGCTTCTTTTTTTTGAGATATGGAGTCTTGCTGTGTTGCCCAGGCAGGAGTGCAGTGGTATGATCTCAGCTC
2161 ACTGCAACCTCTGCCTCCCGGGTTCAACTGATTCTCCTGCCTCAGCCTCCCTGGTAGCTAGGATTACAGGTGCCCGCCAC
2241 CATGCCTGGCTAACTTTTGTAGTTTTAGTAGAGACGGGGTTTTGCCTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCA
2321 AGTGATCCATCCACCTTGGCCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCACTGTCCCTGGCCTCATTGTTCCCTTTT
2401 CTACTTTAAGGAAAGTTTTCATGTTTAATCATCTGGGGAAAGTATGTGAAAAATATTTGTTAAGAAGTATCTCTTTGGAG
2481 CCAAGCCACCTGTCTTGGTTTCTTTCTACTAAGAGCCATAAAGTATAGAAATACTTCTAGTTGTTAAGTGCTTATATTTG
2561 TACCTAGATTTAGTCACACGCTTTTGAGAAAACATCTAGTATGTTATGATCAGCTATTCCTGAGAGCTTGGTTGTTAATC
2641 TATATTTCTATTTCTTAGTGGTAGTCATCTTTGATGAATAAGACTAAAGATTCTCACAGGTTTAAAATTTTATGTCTACT
2721 TTAAGGGTAAAATTATGAGGTTATGGTTCTGGGTGGGTTTTCTCTAGCTAATTCATATCTCAAAGAGTCTCAAAATGTTG
2801 AATTTCAGTGCAAGCTGAATGAGAGATGAGCCATGTACACCCACCGTAAGACCTCATTCCATGTTTGTCCAGTGCCTTTC
2881 AGTGCATTATCAAAGGGAATCCTTCATGGTGTTGCCTTTATTTTCCGGGGAGTAGATCGTGGGATATAGTCTATCTCATT
2961 TTTAATAGTTTACCGCCCCTGGTATACAAAGATAATGACAATAAATCACTGCCATATAACCTTGCTTTTTCCAGAAACAT
3041 GGCTGTTTTGTATTGCTGTAACCACTAAATAGGTTGCCTATACCATTCCTCCTGTGAACAGTGCAGATTTACAGGTTGCA
3121 TGGTCTGGCTTAAGGAGAGCCATACTTGAGACATGTGAGTAAACTGAACTCATATTAGCTGTGCTGCATTTCAGACTTAA
3201 AATCCATTTTTGTGGGGCAGGGTGTGGTGTGTAAAGGGGGGTGTTTGTAATACAAGTTGAAGGCAAAATAAAATGTCCTG
3281 TCTCCCAGATGATATACATCTTATTATTTTTAAAGTTTATTGCTAATTGTAGGAAGGTGAGTTGCAGGTATCTTTGACTA
3361 TGGTCATCTGGGGAAGGAAAATTTTACATTTTACTATTAATGCTCCTTAAGTGTCTATGGAGGTTAAAGAATAAAATGGT
3441 AAATGTTTCTGTGCCTGGTTTGATGGTAACTGGTTAATAGTTACTCACCATTTTATGCAGAGTCACATTAGTTCACACCC
3521 TTTCTGAGAGCCTTTTGGGAGAAGCAGTTTTATTCTCTGAGTGGAACAGAGTTCTTTTTGTTGATAATTTCTAGTTTGCT
3601 CCCTTCGTTATTGCCAACTTTACTGGCATTTTATTTAATGATAGCAGATTGGGAAAATGGCAAATTTAGGTTACGGAGGT
3681 AAATGAGTATATGAAAGCAATTACCTCTAAAGCCAGTTAACAATTATTTTGTAGGTGGGGTACACTCAGCTTAAAGTAAT
3761 GCATTTTTTTTTCCCGTAAAGGCAGAATCCATCTTGTTGCAGATAGCTATCTAAATAATCTCATATCCTCTTTTGCAAAG
3841 ACTACAGAGAATAGGCTATGACAATCTTGTTCAAGCCTTTCCATTTTTTTCCCTGATAACTAAGTAATTTCTTTGAACAT
3921 ACCAAGAAGTATGTAAAAAGTCCATGGCCTTATTCATCCACAAAGTGGCATCCTAGGCCCAGCCTTATCCCTAGCAGTTG
4001 TCCCAGTGCTGCTAGGTTGCTTATCTTGTTTATCTGGAATCACTGTGGAGTGAAATTTTCCACATCATCCAGAATTGCCT
4081 TATTTAAGAAGTAAAACGTTTTAATTTTTAGCCTTTTTTTGGTGGAGTTATTTAATATGTATATCAGAGGATATACTAGA
4161 TGGTAACATTTCTTTCTGTGCTTGGCTATCTTTGTGGACTTCAGGGGCTTCTAAAACAGACAGGACTGTGTTGCCTTTAC
4241 TAAATGGTCTGAGACAGCTATGGTTTTGAATTTTTAGTTTTTTTTTTTTAACCCACTTCCCCTCCTGGTCTCTTCCCTCT
4321 CTGATAATTACCATTCATATGTGAGTGTTAGTGTGCCTCCTTTTAGCATTTTCTTCTTCTCTTTCTGATTCTTCATTTCT
4401 GACTGCCTAGGCAAGGAAACCAGATAACCAAACTTACTAGAACGTTCTTTAAAACACAAGTACAAACTCTGGGACAGGAC
4481 CCAAGACACTTTCCTGTGAAGTGCTGAAAAAGACCTCATTGTATTGGCATTTGATATCAGTTTGATGTAGCTTAGAGTGC
4561 TTCCTGATTCTTGCTGAGTTTCAGGTAGTTGAGATAGAGAGAAGTGAGTCATATTCATATTTTCCCCCTTAGAATAATAT
4641 TTTGAAAGGTTTCATTGCTTCCACTTGAATGCTGCTCTTACAAAAACTGGGGTTACAAGGGTTACTAAATTAGCATCAGT
4721 AGCCAGAGGCAATACCGTTGTCTGGAGGACACCAGCAAACAACACACAACAAAGCAAAACAAACCTTGGGAAACTAAGGC
4801 CATTTGTTTTGTTTTGGTGTCCCCTTTGAAGCCCTGCCTTCTGGCCTTACTCCTGTACAGATATTTTTGACCTATAGGTG
4881 CCTTTATGAGAATTGAGGGTCTGACATCCTGCCCCAAGGAGTAGCTAAAGTAATTGCTAGTGTTTTCAGGGATTTTAACA
4961 TCAGACTGGAATGAATGAATGAAACTTTTTGTCCTTTTTTTTTCTGTTTTTTTTTTTCTAATGTAGTAAGGACTAAGGAA
5041 AACCTTTGGTGAAGACAATCATTTCTCTCTGTTGATGTGGATACTTTTCACACCGTTTATTTAAATGCTTTCTCAATAGG
5121 TCCAGAGCCAGTGTTCTTGTTCAACCTGAAAGTAATGGCTCTGGGTTGGGCCAGACAGTTGCACTCTCTAGTTTGCCCTC
5201 TGCCACAAATTTGATGTGTGACCTTTGGGCAAGTCATTTATCTTCTCTGGGCCTTAGTTGCCTCATCTGTAAAATGAGGG
5281 AGTTGGAGTAGATTAATTATTCCAGCTCTGAAATTCTAAGTGACCTTGGCTACCTTGCAGCAGTTTTGGATTTCTTCCTT
5361 ATCTTTGTTCTGCTGTTTGAGGGGGCTTTTTACTTATTTCCATGTTATTCAAAGGAGACTAGGCTTGATATTTTATTACT
5441 GTTCTTTTATGGACAAAAGGTTACATAGTATGCCCTTAAGACTTAATTTTAACCAAAGGCCTAGCACCACCTTAGGGGCT
5521 GCAATAAACACTTAACGCGCGTGCGCACGCGCGCGCGCACACACACACACACACACACACACACACACAGGTCAGAGTTT
5601 AAGGCTTTCGAGTCATGACATTCTAGCTTTTGAATTGCGTGCACACACACACGCACGCACACACTCTGGTCAGAGTTTAT
5681 TAAGGCTTTCGAGTCATGACATTATAGCTTTTGAGTTGGTGTGTGTGACACCACCCTCCTAAGTGGTGTGTGCTTGTAAT
5761 TTTTTTTTTCAGTGAAAATGGATTGAAAACCTGTTGTTAATGCTTAGTGATATTATGCTCAAAACAAGGAAATTCCCTTG
5841 AACCGTGTCAATTAAACTGGTTTATATGACTCAAGAAAACAATACCAGTAGATGATTATTAACTTTATTCTTGGCTCTTT
5921 TTAGGTCCATTTTGATTAAGTGACTTTTGGCTGGATCATTCAGAGCTCTCTTCTAGCCTACCCTTGGATGAGTACAATTA
6001 ATGAAATTCATATTTTCAAGGACCTGGGAGCCTTCCTTGGGGCTGGGTTGAGGGTGGGGGGTTGGGGAGTCCTGGTAGAG
6081 GCCAGCTTTGTGGTAGCTGGAGAGGAAGGGATGAAACCAGCTGCTGTTGCAAAGGCTGCTTGTCATTGATAGAAGGACTC
6161 ACGGGCTTGGATTGATTAAGACTAAACATGGAGTTGGCAAACTTTCTTCAAGTATTGAGTTCTGTTCAATGCATTGGACA
6241 TGTGATTTAAGGGAAAAGTGTGAATGCTTATAGATGATGAAAACCTGGTGGGCTGCAGAGCCCAGTTTAGAAGAAGTGAG
6321 TTGGGGGTTGGGGACAGATTTGGTGGTGGTATTTCCCAACTGTTTCCTCCCCTAAATTCAGAGGAATGCAGCTATGCCAG
6401 AAGCCAGAGAAGAGCCACTCGTAGCTTCTGCTTTGGGGACAACTGGTCAGTTGAAAGTCCCAGGAGTTCCTTTGTGGCTT
6481 TCTGTATACTTTTGCCTGGTTAAAGTCTGTGGCTAAAAAATAGTCGAACCTTTCTTGAGAACTCTGTAACAAAGTATGTT
6561 TTTGATTAAAAGAGAAAGCCAACTAAA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' agUCAAAACGUAUCUAAACGUGu 5'
            | |||| : |   ||||||| 
Target 5' agATTTTTTTTTTCTTTTGCACt 3'
1351 - 1373 153.00 -5.60
2
miRNA  3' agUCAAAACGUAUCUAAACGUGu 5'
            || |||| |||  ||||:|| 
Target 5' gtAG-TTTGGATATTTTTGTACt 3'
1028 - 1049 152.00 -12.40
3
miRNA  3' agUCA--AA---ACGUAUCUAAACGUGu 5'
            |||  ||   ||| || |||||:|| 
Target 5' ctAGTTGTTAAGTGCTTATATTTGTACc 3'
2537 - 2564 151.00 -10.50
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: SMAD4    [ Functional MTI ]
Validation Method Other
Article - Tsai, Z. Y. Singh, S. Yu, S. L. Kao, L. P. et al.
- J Cell Biochem, 2010
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited supply of different cell types for tissue replacement, drug screening, and functional genomics studies. The hES-T3 cells with normal female karyotype cultured on either mouse embryonic fibroblasts (MEF) in hES medium (containing 4 ng/ml bFGF) (T3MF) or feeder-free Matrigel in MEF-conditioned medium (supplemented with additional 4 ng/ml bFGF) (T3CM) were found to express very similar profiles of mRNAs and microRNAs, indicating that the unlimited self-renewal and pluripotency of hES cells can be maintained by continuing culture on these two conditions. However, the expression profiles, especially microRNAs, of the hES-T3 cells cultured on Matrigel in hES medium supplemented with 4 ng/ml bFGF and 5 ng/ml activin A (T3BA) were found to be different from those of T3MF and T3CM cells. In T3BA cells, four hES cell-specific microRNAs miR-372, miR-302d, miR-367, and miR-200c, as well as three other microRNAs miR-199a, miR-19a, and miR-217, were found to be up-regulated, whereas five miRNAs miR-19b, miR-221, miR-222, let-7b, and let-7c were down-regulated by activin A. Thirteen abundantly differentially expressed mRNAs, including NR4A2, ERBB4, CXCR4, PCDH9, TMEFF2, CD24, and COX6A1 genes, targeted by seven over-expressed miRNAs were identified by inverse expression levels of these seven microRNAs to their target mRNAs in T3BA and T3CM cells. The NR4A2, ERBB4, and CXCR4 target genes were further found to be regulated by EGF and/or TNF. The 50 abundantly differentially expressed genes targeted by five under-expressed miRNAs were also identified. The abundantly expressed mRNAs in T3BA and T3CM cells were also analyzed for the network and signaling pathways, and roles of activin A in cell proliferation and differentiation were found. These findings will help elucidate the complex signaling network which maintains the self-renewal and pluripotency of hES cells.
LinkOut: [PMID: 19885849]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: SMAD4    [ Functional MTI ]
Validation Method
Article - Hafner, M. Landthaler, M. Burger, L. et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 3 for Non-Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: SMAD4    [ Non-Functional MTI ]
Validation Method Luciferase reporter assay , Microarray
Conditions DLD1
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... Interestingly, all miR-17a~92 mimics tested decreased Smad4 mRNA levels, but this downregulation was most profound with miR-18a (Fig. 4C). In the human Smad4 3′-UTR, TargetScan predicts binding sites for miR-17 and miR-19 as well as miR-18a. To determine whether any of these were bona fide target sites, we constructed six sets of psiCHECK2-based sensor plasmids as described above. DLD1 Dicer hypo cells were transfected with these constructs and also control or cognate mimics. The results in Fig. 4D show that of the three sequences tested, only the miR-18a homology region is a bona fide binding site. ...

- Dews, M. Fox, J. L. Hultine, S. Sundaram, et al., 2010, Cancer Res.

Article - Dews, M. Fox, J. L. Hultine, S. Sundaram, et al.
- Cancer Res, 2010
c-Myc stimulates angiogenesis in tumors through mechanisms that remain incompletely understood. Recent work indicates that c-Myc upregulates the miR-17 approximately 92 microRNA cluster and downregulates the angiogenesis inhibitor thrombospondin-1, along with other members of the thrombospondin type 1 repeat superfamily. Here, we show that downregulation of the thrombospondin type 1 repeat protein clusterin in cells overexpressing c-Myc and miR-17 approximately 92 promotes angiogenesis and tumor growth. However, clusterin downregulation by miR-17 approximately 92 is indirect. It occurs as a result of reduced transforming growth factor-beta (TGFbeta) signaling caused by targeting of several regulatory components in this signaling pathway. Specifically, miR-17-5p and miR-20 reduce the expression of the type II TGFbeta receptor and miR-18 limits the expression of Smad4. Supporting these results, in human cancer cell lines, levels of the miR-17 approximately 92 primary transcript MIR17HG negatively correlate with those of many TGFbeta-induced genes that are not direct targets of miR-17 approximately 92 (e.g., clusterin and angiopoietin-like 4). Furthermore, enforced expression of miR-17 approximately 92 in MIR17HG(low) cell lines (e.g., glioblastoma) results in impaired gene activation by TGFbeta. Together, our results define a pathway in which c-Myc activation of miR-17 approximately 92 attenuates the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth.
LinkOut: [PMID: 20940405]
Experimental Support 4 for Non-Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: SMAD4    [ Non-Functional MTI ]
Validation Method
Article - Memczak, S. Jens, M. Elefsinioti, A. Torti, et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 5 for Non-Functional miRNA-Target Interaction
miRNA:Target hsa-miR-19a-3p :: SMAD4    [ Non-Functional MTI ]
Validation Method
Article - Fuziwara, C. S. Kimura, E. T.
- Thyroid, 2013
Background: Excess iodine inhibits thyroid follicular cell proliferation associated with TGFbeta pathway activation, although thyroid cancers are frequently refractory to TGFbeta signaling. TGFbeta pathway is predicted to be regulated by miR-17-92 cluster microRNAs. MicroRNAs are small non-coding RNAs that inhibit target mRNAs translation and have emerged as potent modulators of tumorigenesis. Although BRAFV600E mutation is the most prevalent alteration in thyroid cancer, the impact of iodine intake on BRAF-mediated oncogenesis remains unclear. Therefore, the aim of this study was to investigate high iodine influence in miR-17-92 transcriptional regulation and expression in thyroid cells expressing activated BRAF. Methods: Rat thyroid follicular cells that conditionally express BRAFV600E under doxycycline stimulation (PC-BRAFV600E-6) were derived from PCCl3 line. These cells were treated with doxycycline for 2 days, in the absence or presence of 10 microM sodium iodide. Thyroid cancer cell lines BCPAP and KTC2 were also analyzed. Expression of miR-17-92 cluster and Notch1 was analyzed by qPCR, and expression of these genes was modulated by anti-miR or anti-Notch1 siRNAs transfection. Protein expression was assessed by Western-blot. Luciferase assays were used to quantify Smad4 3'-UTR/miR-19 interaction and Notch signaling activation. TGFbeta responsiveness was evaluated by cell cycle analysis of TGFbeta-treated cells. Results: High iodine blocked BRAFV600E-induced upregulation of miR-17-92, including miR-19a/b. miR-17-92 promoter region analysis revealed putative binding site for Hes1, a transcription factor responsive to Notch signaling. Notch-1 overexpression resulted in miR-19 upregulation in normal thyroid cells, while Notch-1 knockdown blocked BRAF-induced miR-19 expression. Moreover, in anaplastic thyroid cancer cells Notch-1 knockdown reduced miR-19. Expression of BRAFV600E decreased Smad4 protein in normal thyroid cells. Smad4 was validated as a miR-19 target by luciferase assays, which revealed reduced luminescence associated with miR-19 interaction in Smad4 3'-UTR. Iodine treatment restored Smad4 levels in BRAF-activated cells, resulting in enhanced G1-cell cycle arrest in response to TGFbeta. Moreover, this effect was mimicked in papillary thyroid cancer cells treated with anti-miR-19. Conclusion: High iodine abrogates BRAFV600E-induced activation of miR-19, a newly identified Smad4 regulator, through Notch pathway inhibition and restores responsiveness to TGFbeta signaling. Our results indicate that iodine exerts protective effects in thyroid cells, attenuating acute BRAF oncogene-mediated microRNA deregulation.
LinkOut: [PMID: 23998804]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000398417.2 | 3UTR | AUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000398417.2 | 3UTR | AUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000398417.2 | 3UTR | AUUUUUAAGAUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000398417.2 | 3UTR | AUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000398417.2 | 3UTR | AUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000398417.2 | 3UTR | AUUUUUUUUUUCUUUUGCACUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
550 hsa-miR-19a-3p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001794 HOXA5 homeobox A5 2 2
MIRT001795 MECP2 methyl CpG binding protein 2 (Rett syndrome) 4 4
MIRT002958 PTEN phosphatase and tensin homolog 5 9
MIRT003214 ESR1 estrogen receptor 1 4 2
MIRT003426 CCND1 cyclin D1 5 3
MIRT003533 ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 3 3
MIRT003536 NR4A2 nuclear receptor subfamily 4, group A, member 2 3 3
MIRT003781 ATXN1 ataxin 1 5 4
MIRT004334 KAT2B K(lysine) acetyltransferase 2B 3 2
MIRT004337 SOCS1 suppressor of cytokine signaling 1 5 7
MIRT004350 PRMT5 protein arginine methyltransferase 5 2 2
MIRT004452 BCL2L11 BCL2-like 11 (apoptosis facilitator) 2 5
MIRT004593 TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4 8
MIRT004934 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 5 5
MIRT005396 ARIH2 ariadne homolog 2 (Drosophila) 2 2
MIRT005630 SMAD4 SMAD family member 4 4 7
MIRT006179 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4 1
MIRT006475 CUL5 cullin 5 2 1
MIRT006646 TLR2 toll-like receptor 2 3 1
MIRT006787 TNF tumor necrosis factor 3 2
MIRT007118 SUZ12 suppressor of zeste 12 homolog (Drosophila) 2 2
MIRT007119 RAB13 RAB13, member RAS oncogene family 1 1
MIRT007120 MSMO1 methylsterol monooxygenase 1 2 3
MIRT007121 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1 1
MIRT007122 PSAP prosaposin 2 2
MIRT031304 THBS1 thrombospondin 1 2 2
MIRT031305 CTGF connective tissue growth factor 1 1
MIRT031306 DPYSL2 dihydropyrimidinase-like 2 1 1
MIRT031307 VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 1 1
MIRT031308 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 1 1
MIRT031309 RAB14 RAB14, member RAS oncogene family 2 3
MIRT050641 KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1 1
MIRT050642 RNF4 ring finger protein 4 1 1
MIRT050643 PRRC2C proline-rich coiled-coil 2C 1 1
MIRT050644 TMEM87A transmembrane protein 87A 1 1
MIRT050645 MTF2 metal response element binding transcription factor 2 1 1
MIRT050646 GRK6 G protein-coupled receptor kinase 6 1 1
MIRT050647 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 1 1
MIRT050648 WDFY3 WD repeat and FYVE domain containing 3 1 1
MIRT052969 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1 1
MIRT053155 MXD1 MAX dimerization protein 1 3 1
MIRT053165 TF transferrin 3 1
MIRT053789 IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 4 2
MIRT053790 NPEPL1 aminopeptidase-like 1 3 1
MIRT054156 AKT1 v-akt murine thymoma viral oncogene homolog 1 2 2
MIRT054459 ZBTB4 zinc finger and BTB domain containing 4 2 5
MIRT056046 MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 1 1
MIRT056174 OTUD1 OTU domain containing 1 1 1
MIRT056383 ZMYND11 zinc finger, MYND-type containing 11 1 2
MIRT057490 CEP55 centrosomal protein 55kDa 1 2
MIRT057811 SLC30A7 solute carrier family 30 (zinc transporter), member 7 1 2
MIRT060676 KLHL20 kelch-like 20 (Drosophila) 1 1
MIRT060822 CEP350 centrosomal protein 350kDa 1 3
MIRT062706 MLEC malectin 1 3
MIRT063592 FBXO28 F-box protein 28 1 2
MIRT063711 WDR26 WD repeat domain 26 1 2
MIRT063998 KLHL42 kelch domain containing 5 1 1
MIRT064747 CCND2 cyclin D2 1 5
MIRT064795 ZBTB18 zinc finger protein 238 1 2
MIRT065616 CLIC4 chloride intracellular channel 4 1 1
MIRT065885 RAB5B RAB5B, member RAS oncogene family 1 5
MIRT066882 RAB21 RAB21, member RAS oncogene family 1 1
MIRT066935 SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1 1
MIRT067193 STX12 syntaxin 12 1 1
MIRT068828 FNDC3A fibronectin type III domain containing 3A 1 1
MIRT069290 WDR20 WD repeat domain 20 1 1
MIRT069422 SIVA1 SIVA1, apoptosis-inducing factor 1 2
MIRT070993 SMOC1 SPARC related modular calcium binding 1 1 1
MIRT071086 RBM25 RNA binding motif protein 25 1 1
MIRT071480 CALM1 calmodulin 1 (phosphorylase kinase, delta) 1 1
MIRT071816 RNF11 ring finger protein 11 1 4
MIRT071901 ZFYVE9 zinc finger, FYVE domain containing 9 1 1
MIRT072478 RAB8B RAB8B, member RAS oncogene family 1 1
MIRT073803 ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 1 2
MIRT074500 NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1 2
MIRT074889 CHD9 chromodomain helicase DNA binding protein 9 1 1
MIRT075110 C16ORF70 chromosome 16 open reading frame 70 1 3
MIRT075330 SF3B3 splicing factor 3b, subunit 3, 130kDa 1 2
MIRT076024 COX10 cytochrome c oxidase assembly homolog 10 (yeast) 1 4
MIRT076583 NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 1 1
MIRT079342 CCDC137 coiled-coil domain containing 137 1 2
MIRT079465 FN3KRP fructosamine 3 kinase related protein 1 1
MIRT079744 RBBP8 retinoblastoma binding protein 8 1 1
MIRT080177 PRKACB protein kinase, cAMP-dependent, catalytic, beta 1 1
MIRT080680 KIAA1468 KIAA1468 1 1
MIRT081116 LDLR low density lipoprotein receptor 1 4
MIRT082387 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 1 3
MIRT083229 GINS1 GINS complex subunit 1 (Psf1 homolog) 1 1
MIRT085259 CCNT2 cyclin T2 1 1
MIRT085515 SLC37A1 solute carrier family 37 (glycerol-3-phosphate transporter), member 1 1 1
MIRT086398 MFSD6 major facilitator superfamily domain containing 6 1 1
MIRT087602 ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1 1
MIRT087862 CBY1 chibby homolog 1 (Drosophila) 1 2
MIRT087928 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT090333 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1 5
MIRT090801 MBNL1 muscleblind-like splicing regulator 1 1 3
MIRT090896 ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 1 1
MIRT091211 USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 1 1
MIRT091231 FXR1 fragile X mental retardation, autosomal homolog 1 1 1
MIRT091938 ZBTB47 zinc finger and BTB domain containing 47 1 3
MIRT092024 ABHD5 abhydrolase domain containing 5 1 3
MIRT092487 PTPRG protein tyrosine phosphatase, receptor type, G 1 1
MIRT092954 CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1 2
MIRT093076 SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1 1
MIRT094087 PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1 3
MIRT094221 G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1 5
MIRT094526 C5ORF30 chromosome 5 open reading frame 30 1 1
MIRT095135 C5ORF24 chromosome 5 open reading frame 24 1 1
MIRT095198 SMAD5 SMAD family member 5 1 1
MIRT095995 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 1 1
MIRT097459 PAPD4 PAP associated domain containing 4 1 1
MIRT097556 RASA1 RAS p21 protein activator (GTPase activating protein) 1 1 1
MIRT097688 ARRDC3 arrestin domain containing 3 1 1
MIRT099306 QKI QKI, KH domain containing, RNA binding 1 2
MIRT099822 SOX4 SRY (sex determining region Y)-box 4 1 5
MIRT100760 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 1 2
MIRT101801 PNRC1 proline-rich nuclear receptor coactivator 1 1 1
MIRT102245 HBP1 HMG-box transcription factor 1 1 3
MIRT102566 CREB3L2 cAMP responsive element binding protein 3-like 2 1 1
MIRT102614 UBN2 ubinuclein 2 1 4
MIRT104392 ANKIB1 ankyrin repeat and IBR domain containing 1 1 1
MIRT105199 EFR3A EFR3 homolog A (S. cerevisiae) 1 1
MIRT105302 VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1 1
MIRT105429 ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1 6
MIRT107274 FAM73B family with sequence similarity 73, member B 1 1
MIRT107488 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1 1
MIRT108873 HPRT1 hypoxanthine phosphoribosyltransferase 1 1 1
MIRT109826 MID1IP1 MID1 interacting protein 1 1 4
MIRT112758 ADIPOR2 adiponectin receptor 2 1 1
MIRT113257 TMBIM6 transmembrane BAX inhibitor motif containing 6 1 3
MIRT113580 ZDHHC18 zinc finger, DHHC-type containing 18 1 1
MIRT113882 KPNA6 karyopherin alpha 6 (importin alpha 7) 1 3
MIRT117352 TGIF1 TGFB-induced factor homeobox 1 1 2
MIRT125560 SCD stearoyl-CoA desaturase (delta-9-desaturase) 1 1
MIRT126661 RAB18 RAB18, member RAS oncogene family 1 1
MIRT127082 REEP3 receptor accessory protein 3 1 1
MIRT127203 PLAU plasminogen activator, urokinase 1 1
MIRT127441 FAS Fas (TNF receptor superfamily, member 6) 1 1
MIRT129454 CHEK1 checkpoint kinase 1 1 1
MIRT129779 FAM46C family with sequence similarity 46, member C 1 1
MIRT129958 TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1 1
MIRT130677 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT130845 ZBTB7B zinc finger and BTB domain containing 7B 1 1
MIRT132676 RASSF5 Ras association (RalGDS/AF-6) domain family member 5 1 1
MIRT132981 WNK1 WNK lysine deficient protein kinase 1 1 1
MIRT133161 GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1 1
MIRT133376 BCL7A B-cell CLL/lymphoma 7A 1 1
MIRT134301 GPR137B G protein-coupled receptor 137B 1 1
MIRT136439 PLXNC1 plexin C1 1 1
MIRT137249 AGO1 eukaryotic translation initiation factor 2C, 1 1 1
MIRT137289 MBNL2 muscleblind-like splicing regulator 2 1 1
MIRT137383 MACF1 microtubule-actin crosslinking factor 1 1 1
MIRT137540 RCOR1 REST corepressor 1 1 1
MIRT138187 KLHDC2 kelch domain containing 2 1 1
MIRT138346 FRMD6 FERM domain containing 6 1 1
MIRT139871 BTF3L4 basic transcription factor 3-like 4 1 4
MIRT139915 KLF13 Kruppel-like factor 13 1 1
MIRT140246 DMXL2 Dmx-like 2 1 1
MIRT140961 NPTN neuroplastin 1 1
MIRT141350 ABHD17C family with sequence similarity 108, member C1 1 1
MIRT141934 SMG1 smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 1 5
MIRT142377 TNRC6A trinucleotide repeat containing 6A 1 3
MIRT142988 TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1 1
MIRT144147 PHF13 PHD finger protein 13 1 1
MIRT144488 MIER1 mesoderm induction early response 1 homolog (Xenopus laevis) 1 1
MIRT144865 MAP2K3 mitogen-activated protein kinase kinase 3 1 1
MIRT145462 NF1 neurofibromin 1 1 1
MIRT147074 DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1 1
MIRT147919 CAMTA1 calmodulin binding transcription activator 1 1 1
MIRT147970 VAMP3 vesicle-associated membrane protein 3 1 1
MIRT148866 ANKRD12 ankyrin repeat domain 12 1 1
MIRT149309 PDE4A phosphodiesterase 4A, cAMP-specific 1 1
MIRT150380 CC2D1A coiled-coil and C2 domain containing 1A 1 1
MIRT150616 SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 1 1
MIRT151584 ZNF526 zinc finger protein 526 1 1
MIRT153283 FAM83D family with sequence similarity 83, member D 1 1
MIRT156402 RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1 1
MIRT156586 COQ10B coenzyme Q10 homolog B (S. cerevisiae) 1 1
MIRT157707 CAB39 calcium binding protein 39 1 1
MIRT158798 PPARA peroxisome proliferator-activated receptor alpha 1 1
MIRT159103 NRBP1 nuclear receptor binding protein 1 1 1
MIRT159677 AFTPH aftiphilin 1 1
MIRT162256 LMLN leishmanolysin-like (metallopeptidase M8 family) 1 2
MIRT162697 ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1 1
MIRT164476 RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1 1
MIRT166255 C5ORF51 chromosome 5 open reading frame 51 1 2
MIRT166399 MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1 1
MIRT168650 MAPK14 mitogen-activated protein kinase 14 1 1
MIRT170951 IKZF1 IKAROS family zinc finger 1 (Ikaros) 1 1
MIRT172151 FZD6 frizzled family receptor 6 1 5
MIRT172594 CNOT7 CCR4-NOT transcription complex, subunit 7 1 1
MIRT173377 TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 1 1
MIRT175592 OCRL oculocerebrorenal syndrome of Lowe 1 1
MIRT176283 DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 1 1
MIRT177384 WAC WW domain containing adaptor with coiled-coil 1 1
MIRT178061 SAMD8 sterile alpha motif domain containing 8 1 1
MIRT178924 C11ORF57 chromosome 11 open reading frame 57 1 2
MIRT179065 PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 1 3
MIRT179423 TBRG1 transforming growth factor beta regulator 1 1 3
MIRT187749 ESYT1 extended synaptotagmin-like protein 1 1 1
MIRT188209 RAP1B RAP1B, member of RAS oncogene family 1 1
MIRT193021 TMOD3 tropomodulin 3 (ubiquitous) 1 4
MIRT193529 RORA RAR-related orphan receptor A 1 2
MIRT195613 FAM195A family with sequence similarity 195, member A 1 3
MIRT195752 ATMIN ATM interactor 1 3
MIRT197826 DCAF7 DDB1 and CUL4 associated factor 7 1 2
MIRT203045 AMMECR1L AMME chromosomal region gene 1-like 1 2
MIRT208722 MED12L mediator complex subunit 12-like 1 3
MIRT209477 EIF4A2 eukaryotic translation initiation factor 4A2 1 4
MIRT211502 ELMOD2 ELMO/CED-12 domain containing 2 1 2
MIRT213428 MOB1B MOB kinase activator 1B 1 3
MIRT213702 AFF1 AF4/FMR2 family, member 1 1 1
MIRT213973 DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) 1 1
MIRT217599 NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 1 1
MIRT220279 TMEM106B transmembrane protein 106B 1 1
MIRT227992 NFIB nuclear factor I/B 1 2
MIRT230215 RPS4Y1 ribosomal protein S4, Y-linked 1 1 1
MIRT230963 PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1 1
MIRT243090 LCLAT1 lysocardiolipin acyltransferase 1 1 3
MIRT243389 SKIL SKI-like oncogene 1 5
MIRT245295 BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 1 1
MIRT248070 SLC38A2 solute carrier family 38, member 2 1 3
MIRT250718 DEF8 differentially expressed in FDCP 8 homolog (mouse) 1 1
MIRT251362 RNF167 ring finger protein 167 1 1
MIRT252920 BCL3 B-cell CLL/lymphoma 3 1 1
MIRT253410 EVI5L ecotropic viral integration site 5-like 1 2
MIRT259381 SLC6A8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 1 2
MIRT260199 KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 1 1
MIRT260227 ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 1 1
MIRT275173 BTG1 B-cell translocation gene 1, anti-proliferative 1 1
MIRT275508 ZIC5 Zic family member 5 1 1
MIRT278994 GMFB glia maturation factor, beta 1 6
MIRT280867 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 1 3
MIRT283021 NFIA nuclear factor I/A 1 1
MIRT284268 ALG1 asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT287194 STAT5B signal transducer and activator of transcription 5B 1 1
MIRT290693 POLI polymerase (DNA directed) iota 1 2
MIRT291961 CHERP calcium homeostasis endoplasmic reticulum protein 1 1
MIRT295902 DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) 1 1
MIRT296524 STX16 syntaxin 16 1 1
MIRT298581 BRWD1 bromodomain and WD repeat domain containing 1 1 2
MIRT313089 RNF44 ring finger protein 44 1 2
MIRT313686 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1 1
MIRT322045 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 2
MIRT323126 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 1 1
MIRT323692 PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 1 2
MIRT367152 HIST2H4A histone cluster 2, H4a 1 3
MIRT367176 HIST2H4B histone cluster 2, H4b 1 3
MIRT400560 MB21D2 Mab-21 domain containing 2 1 1
MIRT402567 ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 1 1
MIRT405626 WBP4 WW domain binding protein 4 1 2
MIRT438094 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT438478 CD22 CD22 molecule 2 1
MIRT438801 MYC v-myc myelocytomatosis viral oncogene homolog (avian) 1 1
MIRT438808 DNMT1 DNA (cytosine-5-)-methyltransferase 1 1 1
MIRT456095 MB21D1 Mab-21 domain containing 1 1 3
MIRT457965 PTPRB protein tyrosine phosphatase, receptor type, B 1 1
MIRT460412 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1 2
MIRT462956 ZNF800 zinc finger protein 800 1 7
MIRT463058 ZNF644 zinc finger protein 644 1 1
MIRT463650 YY1 YY1 transcription factor 1 4
MIRT463909 WNT7B wingless-type MMTV integration site family, member 7B 1 1
MIRT466377 TGOLN2 trans-golgi network protein 2 1 3
MIRT466813 STX6 syntaxin 6 1 4
MIRT468242 SGK1 serum/glucocorticoid regulated kinase 1 1 2
MIRT468564 SERINC3 serine incorporator 3 1 5
MIRT469279 RHOB ras homolog family member B 1 4
MIRT470338 PPP6R1 protein phosphatase 6, regulatory subunit 1 1 1
MIRT470388 PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 1 1
MIRT471566 PATL1 protein associated with topoisomerase II homolog 1 (yeast) 1 4
MIRT472561 NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 1 2
MIRT472785 MTMR6 myotubularin related protein 6 1 4
MIRT473735 MAP3K9 mitogen-activated protein kinase kinase kinase 9 1 1
MIRT474479 KLHL11 kelch-like 11 (Drosophila) 1 4
MIRT474747 KIF13A kinesin family member 13A 1 3
MIRT474952 KCTD10 potassium channel tetramerisation domain containing 10 1 2
MIRT475199 IMPDH1P11 IMP (inosine monophosphate) dehydrogenase 1 pseudogene 11 1 3
MIRT476915 FBLIM1 filamin binding LIM protein 1 1 2
MIRT477372 EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 1 2
MIRT477479 ELL2 elongation factor, RNA polymerase II, 2 1 1
MIRT478114 DLG5 discs, large homolog 5 (Drosophila) 1 3
MIRT478218 DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1 2
MIRT479662 CD164 CD164 molecule, sialomucin 1 2
MIRT479821 CCNA2 cyclin A2 1 4
MIRT480021 CAPRIN2 caprin family member 2 1 2
MIRT480846 BLCAP bladder cancer associated protein 1 6
MIRT481615 ARHGAP1 Rho GTPase activating protein 1 1 4
MIRT481864 ANKRD50 ankyrin repeat domain 50 1 1
MIRT482516 ACTB actin, beta 1 2
MIRT482595 ABHD14B abhydrolase domain containing 14B 1 1
MIRT483460 YTHDF1 YTH domain family, member 1 1 3
MIRT484947 ZFYVE26 zinc finger, FYVE domain containing 26 1 2
MIRT485130 SECISBP2L SECIS binding protein 2-like 1 3
MIRT485564 FOXQ1 forkhead box Q1 1 1
MIRT485653 DICER1 dicer 1, ribonuclease type III 1 2
MIRT485806 ARPP19 cAMP-regulated phosphoprotein, 19kDa 1 2
MIRT486737 CNOT4 CCR4-NOT transcription complex, subunit 4 1 3
MIRT491635 PDRG1 p53 and DNA-damage regulated 1 1 5
MIRT491940 WDR45B WDR45-like 1 4
MIRT492241 SLC48A1 solute carrier family 48 (heme transporter), member 1 1 1
MIRT493101 MMGT1 membrane magnesium transporter 1 1 6
MIRT494487 BRWD3 bromodomain and WD repeat domain containing 3 1 1
MIRT495274 NICN1 nicolin 1 1 2
MIRT496505 G6PC glucose-6-phosphatase, catalytic subunit 1 1
MIRT498464 PTBP2 polypyrimidine tract binding protein 2 1 5
MIRT500408 ZMAT3 zinc finger, matrin-type 3 1 5
MIRT500677 TRIM37 tripartite motif containing 37 1 1
MIRT501253 SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 1 4
MIRT501531 PPP1R15B protein phosphatase 1, regulatory subunit 15B 1 5
MIRT501662 PHLDA3 pleckstrin homology-like domain, family A, member 3 1 1
MIRT501792 NRBF2 nuclear receptor binding factor 2 1 3
MIRT501994 MAPK1 mitogen-activated protein kinase 1 1 5
MIRT502764 CLIP1 CAP-GLY domain containing linker protein 1 1 5
MIRT502979 CCNL1 cyclin L1 1 4
MIRT503054 CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 1 2
MIRT503467 ZNF154 zinc finger protein 154 1 3
MIRT503674 SLC46A1 solute carrier family 46 (folate transporter), member 1 1 1
MIRT505253 UBE2D3 ubiquitin-conjugating enzyme E2D 3 1 1
MIRT505526 SPATA2 spermatogenesis associated 2 1 2
MIRT505700 SESN3 sestrin 3 1 1
MIRT505788 SATB1 SATB homeobox 1 1 2
MIRT506351 NUP54 nucleoporin 54kDa 1 4
MIRT506470 NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1 2
MIRT506697 LZIC leucine zipper and CTNNBIP1 domain containing 1 2
MIRT507968 BEND3 BEN domain containing 3 1 4
MIRT509028 PALM2-AKAP2 PALM2-AKAP2 readthrough 1 1
MIRT509047 AKAP2 A kinase (PRKA) anchor protein 2 1 1
MIRT510563 USP8 ubiquitin specific peptidase 8 1 2
MIRT510725 SPG20 spastic paraplegia 20 (Troyer syndrome) 1 3
MIRT510856 RAN RAN, member RAS oncogene family 1 5
MIRT510948 PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 1 4
MIRT510985 PFN2 profilin 2 1 3
MIRT511153 MRPL17 mitochondrial ribosomal protein L17 1 3
MIRT511966 ELOVL5 ELOVL fatty acid elongase 5 1 4
MIRT512136 CREBL2 cAMP responsive element binding protein-like 2 1 5
MIRT512576 DCC deleted in colorectal carcinoma 1 2
MIRT512705 ZNF134 zinc finger protein 134 1 3
MIRT513482 ADRM1 adhesion regulating molecule 1 1 1
MIRT513597 ZFAND5 zinc finger, AN1-type domain 5 1 3
MIRT513625 VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 1 2
MIRT513720 RBM20 RNA binding motif protein 20 1 2
MIRT513914 GRB10 growth factor receptor-bound protein 10 1 3
MIRT513950 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 1 3
MIRT521318 RRAGD Ras-related GTP binding D 1 2
MIRT524508 CEP170 centrosomal protein 170kDa 1 2
MIRT529430 MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 1 1
MIRT530121 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1 1
MIRT533711 TMEM64 transmembrane protein 64 1 2
MIRT534274 SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7 1 1
MIRT535359 PFN1 profilin 1 1 1
MIRT538084 DGKH diacylglycerol kinase, eta 1 1
MIRT538502 CLOCK clock homolog (mouse) 1 2
MIRT539382 ADSS adenylosuccinate synthase 1 4
MIRT541005 ZNF367 zinc finger protein 367 1 2
MIRT541137 RAB34 RAB34, member RAS oncogene family 1 1
MIRT543097 TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1 1
MIRT543213 TMEM117 transmembrane protein 117 1 1
MIRT543559 RPF2 ribosome production factor 2 homolog (S. cerevisiae) 1 2
MIRT544722 NDRG1 N-myc downstream regulated 1 1 1
MIRT544977 MFF mitochondrial fission factor 1 2
MIRT545800 ZNF772 zinc finger protein 772 1 2
MIRT546397 STOX2 storkhead box 2 1 2
MIRT546426 SNX5 sorting nexin 5 1 1
MIRT546777 RLIM ring finger protein, LIM domain interacting 1 1
MIRT546860 RAB1A RAB1A, member RAS oncogene family 1 1
MIRT546958 SFTPA1 surfactant protein A1 1 1
MIRT547031 POGZ pogo transposable element with ZNF domain 1 1
MIRT547496 MBNL3 muscleblind-like splicing regulator 3 1 2
MIRT548085 GIGYF1 GRB10 interacting GYF protein 1 1 2
MIRT548105 GFPT1 glutamine--fructose-6-phosphate transaminase 1 1 2
MIRT548414 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 1 1
MIRT548507 E2F8 E2F transcription factor 8 1 2
MIRT548607 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) 1 1
MIRT548734 CREBRF CREB3 regulatory factor 1 1
MIRT548850 CERCAM cerebral endothelial cell adhesion molecule 1 1
MIRT548924 CHEK2 checkpoint kinase 2 1 2
MIRT549040 CASZ1 castor zinc finger 1 1 2
MIRT549185 BMP3 bone morphogenetic protein 3 1 1
MIRT549336 ARHGAP12 Rho GTPase activating protein 12 1 3
MIRT549357 ARC activity-regulated cytoskeleton-associated protein 1 1
MIRT549466 ACSL4 acyl-CoA synthetase long-chain family member 4 1 2
MIRT549492 ACBD5 acyl-CoA binding domain containing 5 1 2
MIRT550132 ZNF138 zinc finger protein 138 1 1
MIRT550205 MAVS mitochondrial antiviral signaling protein 1 2
MIRT550986 RBM38 RNA binding motif protein 38 1 1
MIRT551821 TMEM138 transmembrane protein 138 1 1
MIRT552148 DAD1 defender against cell death 1 1 2
MIRT552843 WNK3 WNK lysine deficient protein kinase 3 1 1
MIRT552877 WASL Wiskott-Aldrich syndrome-like 1 2
MIRT553207 UBE2A ubiquitin-conjugating enzyme E2A 1 1
MIRT553214 TXLNG taxilin gamma 1 1
MIRT553353 TRPC3 transient receptor potential cation channel, subfamily C, member 3 1 2
MIRT553390 TRIM33 tripartite motif containing 33 1 2
MIRT554049 SOX6 SRY (sex determining region Y)-box 6 1 1
MIRT554947 RAP1A RAP1A, member of RAS oncogene family 1 2
MIRT555086 PURG purine-rich element binding protein G 1 1
MIRT555201 PRUNE2 prune homolog 2 (Drosophila) 1 1
MIRT555245 PRICKLE2 prickle homolog 2 (Drosophila) 1 1
MIRT556080 MPRIP myosin phosphatase Rho interacting protein 1 2
MIRT556200 MCC mutated in colorectal cancers 1 1
MIRT556867 JAZF1 JAZF zinc finger 1 1 1
MIRT557212 HNRNPF heterogeneous nuclear ribonucleoprotein F 1 2
MIRT557567 GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1 1
MIRT557776 FRS2 fibroblast growth factor receptor substrate 2 1 2
MIRT557911 FBXO8 F-box protein 8 1 1
MIRT558267 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 1 1
MIRT558406 DEPDC1 DEP domain containing 1 1 1
MIRT558492 DBN1 drebrin 1 1 1
MIRT558776 CFL2 cofilin 2 (muscle) 1 1
MIRT559413 GDNF glial cell derived neurotrophic factor 1 2
MIRT559486 ARL8A ADP-ribosylation factor-like 8A 1 2
MIRT559688 AGO3 eukaryotic translation initiation factor 2C, 3 1 1
MIRT560046 ZNF680 zinc finger protein 680 1 1
MIRT560641 ZNF107 zinc finger protein 107 1 2
MIRT563097 PABPC4L poly(A) binding protein, cytoplasmic 4-like 1 1
MIRT563189 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 1 1
MIRT563798 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 1
MIRT564185 CLVS2 clavesin 2 1 1
MIRT564537 CCDC80 coiled-coil domain containing 80 1 1
MIRT564641 ZNF544 zinc finger protein 544 1 1
MIRT564784 ZDHHC7 zinc finger, DHHC-type containing 7 1 2
MIRT566160 RACGAP1 Rac GTPase activating protein 1 1 1
MIRT567525 FGFR1OP FGFR1 oncogene partner 1 1
MIRT571672 RRAS2 related RAS viral (r-ras) oncogene homolog 2 1 1
MIRT575745 Zfp618 zinc fingerprotein 618 1 1
MIRT614961 HOMER1 homer homolog 1 (Drosophila) 1 1
MIRT620045 ODF4 outer dense fiber of sperm tails 4 1 1
MIRT625044 MBD3 methyl-CpG binding domain protein 3 1 1
MIRT632672 MTX3 metaxin 3 1 1
MIRT644933 PTCD2 pentatricopeptide repeat domain 2 1 1
MIRT668496 ETV3 ets variant 3 1 1
MIRT675087 C6orf132 chromosome 6 open reading frame 132 1 1
MIRT681481 DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 1 1
MIRT683140 MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1 1
MIRT683184 UBL3 ubiquitin-like 3 1 1
MIRT693228 KIAA0907 KIAA0907 1 3
MIRT697757 USP37 ubiquitin specific peptidase 37 1 2
MIRT698245 TMEM2 transmembrane protein 2 1 1
MIRT698796 STK38 serine/threonine kinase 38 1 2
MIRT702410 KITLG KIT ligand 1 1
MIRT703537 FKBP15 FK506 binding protein 15, 133kDa 1 2
MIRT705008 CAMSAP1 calmodulin regulated spectrin-associated protein 1 1 1
MIRT715058 TMTC1 transmembrane and tetratricopeptide repeat containing 1 1 1
MIRT726019 ZNF721 zinc finger protein 721 1 1
MIRT726045 ZNF217 zinc finger protein 217 1 1
MIRT726094 XIAP X-linked inhibitor of apoptosis 1 1
MIRT726098 WNT10A wingless-type MMTV integration site family, member 10A 1 1
MIRT726107 WDR1 WD repeat domain 1 1 1
MIRT726112 WBP2 WW domain binding protein 2 1 1
MIRT726149 VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 1 1
MIRT726240 TRAK2 trafficking protein, kinesin binding 2 1 1
MIRT726244 TP53INP1 tumor protein p53 inducible nuclear protein 1 1 1
MIRT726245 TP53 tumor protein p53 1 1
MIRT726258 TNPO2 transportin 2 1 1
MIRT726260 TNIP1 TNFAIP3 interacting protein 1 1 1
MIRT726266 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1 1
MIRT726276 TMEM9B TMEM9 domain family, member B 1 1
MIRT726336 TFB1M transcription factor B1, mitochondrial 1 1
MIRT726395 TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 1 1
MIRT726424 STK4 serine/threonine kinase 4 1 1
MIRT726479 SNX17 sorting nexin 17 1 1
MIRT726500 SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 1 1
MIRT726553 SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1 1
MIRT726582 SHCBP1 SHC SH2-domain binding protein 1 1 1
MIRT726592 SH3KBP1 SH3-domain kinase binding protein 1 1 1
MIRT726628 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT726630 SEPHS2 selenophosphate synthetase 2 1 1
MIRT726638 SEL1L sel-1 suppressor of lin-12-like (C. elegans) 1 1
MIRT726640 SEC63 SEC63 homolog (S. cerevisiae) 1 1
MIRT726650 SBF2 SET binding factor 2 1 1
MIRT726672 S1PR2 sphingosine-1-phosphate receptor 2 1 1
MIRT726724 RNF216 ring finger protein 216 1 1
MIRT726736 RNF111 ring finger protein 111 1 1
MIRT726749 RGL1 ral guanine nucleotide dissociation stimulator-like 1 1 1
MIRT726782 RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1 1
MIRT726784 RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 1 1
MIRT726785 RAP2C RAP2C, member of RAS oncogene family 1 1
MIRT726795 RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 1 1
MIRT726819 RAB2B RAB2B, member RAS oncogene family 1 1
MIRT726855 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1 1
MIRT726939 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 1 1
MIRT726944 PIGS phosphatidylinositol glycan anchor biosynthesis, class S 1 1
MIRT726959 PGM2L1 phosphoglucomutase 2-like 1 1 1
MIRT726964 PGK1 phosphoglycerate kinase 1 1 1
MIRT727000 PCDH10 protocadherin 10 1 1
MIRT727013 PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 1 1
MIRT727030 OTUD7B OTU domain containing 7B 1 1
MIRT727035 OTUD4 OTU domain containing 4 1 1
MIRT727114 NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 1 1
MIRT727142 MTMR12 myotubularin related protein 12 1 1
MIRT727189 MKL2 MKL/myocardin-like 2 1 1
MIRT727217 MEF2A myocyte enhancer factor 2A 1 1
MIRT727225 MCM3AP-AS1 MCM3AP antisense RNA 1 1 1
MIRT727238 MBD4 methyl-CpG binding domain protein 4 1 1
MIRT727252 MAP3K14 mitogen-activated protein kinase kinase kinase 14 1 1
MIRT727293 LOC613266 uncharacterized LOC613266 1 1
MIRT727300 LIN9 lin-9 homolog (C. elegans) 1 1
MIRT727334 KLHL3 kelch-like 3 (Drosophila) 1 1
MIRT727351 KIF3A kinesin family member 3A 1 1
MIRT727359 CCSER2 family with sequence similarity 190, member B 1 1
MIRT727366 ATG14 autophagy related 14 1 1
MIRT727383 KATNAL1 katanin p60 subunit A-like 1 1 1
MIRT727400 JARID2 jumonji, AT rich interactive domain 2 1 1
MIRT727447 INO80 INO80 homolog (S. cerevisiae) 1 1
MIRT727487 HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 1 1
MIRT727495 HIPK3 homeodomain interacting protein kinase 3 1 1
MIRT727501 HIC1 hypermethylated in cancer 1 1 1
MIRT727502 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT727513 HDAC4 histone deacetylase 4 1 1
MIRT727525 GRSF1 G-rich RNA sequence binding factor 1 1 1
MIRT727530 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1 1
MIRT727607 GAK cyclin G associated kinase 1 1
MIRT727650 FOXP1 forkhead box P1 1 1
MIRT727663 FBXO48 F-box protein 48 1 1
MIRT727680 FBXO10 F-box protein 10 1 1
MIRT727697 FAM73A family with sequence similarity 73, member A 1 1
MIRT727721 DENND6A DENN/MADD domain containing 6A 1 1
MIRT727728 FAM102A family with sequence similarity 102, member A 1 1
MIRT727737 EXOC7 exocyst complex component 7 1 1
MIRT727753 EPS15 epidermal growth factor receptor pathway substrate 15 1 1
MIRT727759 EPN2 epsin 2 1 1
MIRT727790 EIF4E2 eukaryotic translation initiation factor 4E family member 2 1 1
MIRT727794 EHD1 EH-domain containing 1 1 1
MIRT727838 DUT deoxyuridine triphosphatase 1 1
MIRT727852 DSCR3 Down syndrome critical region gene 3 1 1
MIRT727971 CNOT6 CCR4-NOT transcription complex, subunit 6 1 1
MIRT727986 CIT citron (rho-interacting, serine/threonine kinase 21) 1 1
MIRT728042 CBX7 chromobox homolog 7 1 1
MIRT728043 CBX5 chromobox homolog 5 1 1
MIRT728061 IDNK idnK, gluconokinase homolog (E. coli) 1 1
MIRT728099 C2orf42 chromosome 2 open reading frame 42 1 1
MIRT728105 PRR14L proline rich 14-like 1 1
MIRT728121 SDE2 SDE2 telomere maintenance homolog (S. pombe) 1 1
MIRT728134 C15orf38 chromosome 15 open reading frame 38 1 1
MIRT728148 SPTSSA serine palmitoyltransferase, small subunit A 1 1
MIRT728155 GSKIP GSK3B interacting protein 1 1
MIRT728182 BTBD7 BTB (POZ) domain containing 7 1 1
MIRT728197 BRD9 bromodomain containing 9 1 1
MIRT728216 BCL7B B-cell CLL/lymphoma 7B 1 1
MIRT728235 B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1 1
MIRT728239 AZIN1 antizyme inhibitor 1 1 1
MIRT728245 ATXN7 ataxin 7 1 1
MIRT728248 ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 1 1
MIRT728272 ATG5 autophagy related 5 1 1
MIRT728274 ATG2B autophagy related 2B 1 1
MIRT728308 ARMC8 armadillo repeat containing 8 1 1
MIRT728318 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 1 1
MIRT728352 ANGEL2 angel homolog 2 (Drosophila) 1 1
MIRT728356 ALG2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 1 1
MIRT728370 AHDC1 AT hook, DNA binding motif, containing 1 1 1
Error report submission
MIRT ID*
Your e-Mail*
Memo*