Accession ID: MIRT005865 [miRNA, hsa-miR-106b-5p :: PTEN, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-106bLinkOut: [miRBase ]
Description Homo sapiens miR-106b stem-loop
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-106b-5p
Mature Sequence 12| UAAAGUGCUGACAGUGCAGAU |32
Evidence Experimental
Experiments Cloned
Putative hsa-miR-106b-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol PTEN LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, PTEN1, TEP1
Description phosphatase and tensin homolog
Transcript NM_0003    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on PTEN LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of PTEN
(miRNA target sites are highlighted)
>PTEN|NM_0003|3'UTR
   1 TGAATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAA
  81 TGGCAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACAT
 161 CCACAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAG
 241 GACATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACT
 321 GATGTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTT
 401 CACATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACAT
 481 TCTAATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATAT
 561 ACCATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGT
 641 CACTGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGG
 721 GGTACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACAC
 801 AGCAACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGAT
 881 TTATTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGT
 961 TAGTACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCT
1041 GCCTGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAG
1121 TAAGCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACAT
1201 TCTATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATA
1281 CATATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAA
1361 AAAAAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTT
1521 CAATTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTA
1601 TTGTAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTT
1681 GACATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTC
1761 ACTAGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATG
1841 GCAAATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCA
1921 TTCAACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATT
2001 GATTGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTC
2081 TTTCATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGT
2161 TACAATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGA
2241 CATTATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTT
2321 TCAATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATA
2401 TATAAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACT
2481 GAAAGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCT
2561 CTGAGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTT
2641 TAAGAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAA
2721 GGGTAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAA
2801 ATGTTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACG
2881 ATGGCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAA
2961 CTGTGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTT
3041 TTCATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGT
3121 GCTGTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAAT
3201 GCCTCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAA
3281 AACTGATTAAAGTCTCATTCTTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' uagacgugaCAGUCGUGAAAu 5'
                   | ::||||||| 
Target 5' attaataaaGATGGCACTTTc 3'
262 - 282 144.00 -7.30
2
miRNA  3' uaGACG--UGACAG--UCGUGAAAu 5'
            ||||  ::|||:   |||:||| 
Target 5' caCTGCTTGTTGTTTGCGCATTTTt 3'
641 - 665 139.00 -13.10
3
miRNA  3' uaGACGUGACAGUCGUGAAAu 5'
            :| :|| || |||::||| 
Target 5' gaTTCTACAGTAAGCGTTTTt 3'
1111 - 1131 131.00 -8.40
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-106b-5p :: PTEN    [ Functional MTI ]
Validation Method Other
Article - Pichiorri, F. Suh, S. S. Ladetto, M. Kuehl, et al.
- Proc Natl Acad Sci U S A, 2008
Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marrow PCs from subjects with MM (n = 16), monoclonal gammopathy of undetermined significance (MGUS) (n = 6), and normal donors (n = 6). We identified overexpression of miR-21, miR-106b approximately 25 cluster, miR-181a and b in MM and MGUS samples with respect to healthy PCs. Selective up-regulation of miR-32 and miR-17 approximately 92 cluster was identified in MM subjects and cell lines but not in MGUS subjects or healthy PCs. Furthermore, two miRNAs, miR-19a and 19b, that are part of the miR-17 approximately 92 cluster, were shown to down regulate expression of SOCS-1, a gene frequently silenced in MM that plays a critical role as inhibitor of IL-6 growth signaling. We also identified p300-CBP-associated factor, a gene involved in p53 regulation, as a bona fide target of the miR106b approximately 25 cluster, miR-181a and b, and miR-32. Xenograft studies using human MM cell lines treated with miR-19a and b, and miR-181a and b antagonists resulted in significant suppression of tumor growth in nude mice. In summary, we have described a MM miRNA signature, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis.
LinkOut: [PMID: 18728182]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-106b-5p :: PTEN    [ Functional MTI ]
Validation Method Luciferase reporter assay
Conditions HEK293T
Location of target site 3'UTR
Tools used in this research DAVID , DIANA-microT , miRanda , mirGen , PicTar , TargetScan , TargetScanS
Original Description (Extracted from the article) ... Fig. 2A demonstrates that, with the exception of E2F3 and MAPK9, miR-17 significantly influences all target genes tested irrespective of an activating or inhibiting function in cell proliferation. Among the pro-proliferative targets, the strongest effects were seen for CCND1 (appr. 47% reduction in normalized Firefly activity) and E2F1 (29% reduction). RBL2 and CDKN1A showed the strongest reductions in activity among the set of anti-proliferative proteins tested (52% and 30% respectively). As seen in Figs. 2B and 2C, miR- 20a and miR-106b showed highly similar behavior compared to miR-17 regarding significant Firefly activity reductions and relative influences between the analyzed target genes. ...

- Trompeter, H. I. Abbad, H. Iwaniuk, K. M. et al., 2011, PLoS One.

Article - Trompeter, H. I. Abbad, H. Iwaniuk, K. M. et al.
- PLoS One, 2011
BACKGROUND: MicroRNAs are short ( approximately 22 nt) non-coding regulatory RNAs that control gene expression at the post-transcriptional level. Here the functional impact of microRNAs on cell cycle arrest during neuronal lineage differentiation of unrestricted somatic stem cells from human cord blood (USSC) was analyzed. METHODOLOGY/PRINCIPAL FINDINGS: Expression profiling revealed downregulation of microRNAs miR-17, -20a, and -106b in USSC differentiated into neuronal lineage but not in USSC differentiated into osteogenic lineage. Transfection experiments followed by Ki67 immunostainings demonstrated that each of these microRNAs was able to promote proliferation of native USSC and to prevent in part cell cycle arrest during neuronal lineage differentiation of USSC. Bioinformatic target gene predictions followed by experimental target gene validations revealed that miR-17, -20a, and -106b act in a common manner by downregulating an overlapping set of target genes mostly involved in regulation and execution of G(1)/S transition. Pro-proliferative target genes cyclinD1 (CCND1) and E2F1 as well as anti-proliferative targets CDKN1A (p21), PTEN, RB1, RBL1 (p107), RBL2 (p130) were shown as common targets for miR-17, -20a, and -106b. Furthermore, these microRNAs also downregulate WEE1 which is involved in G(2)/M transition. Most strikingly, miR-17, -20a, and -106b were found to promote cell proliferation by increasing the intracellular activity of E2F transcription factors, despite the fact that miR-17, -20a, and -106b directly target the transcripts that encode for this protein family. CONCLUSIONS/SIGNIFICANCE: Mir-17, -20a, and -106b downregulate a common set of pro- and anti-proliferative target genes to impact cell cycle progression of USSC and increase intracellular activity of E2F transcription factors to govern G(1)/S transition.
LinkOut: [PMID: 21283765]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
222 hsa-miR-106b-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000372 ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 4 5
MIRT000373 APP amyloid beta (A4) precursor protein 3 4
MIRT000603 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 5 11
MIRT003045 E2F1 E2F transcription factor 1 5 7
MIRT004333 KAT2B K(lysine) acetyltransferase 2B 4 3
MIRT004466 VEGFA vascular endothelial growth factor A 2 2
MIRT004664 RB1 retinoblastoma 1 4 4
MIRT005847 TCEAL1 transcription elongation factor A (SII)-like 1 4 3
MIRT005861 CCND1 cyclin D1 1 1
MIRT005862 CCND2 cyclin D2 1 1
MIRT005863 E2F3 E2F transcription factor 3 1 1
MIRT005864 MAPK9 mitogen-activated protein kinase 9 1 1
MIRT005865 PTEN phosphatase and tensin homolog 2 2
MIRT005866 RBL1 retinoblastoma-like 1 (p107) 1 1
MIRT005867 RBL2 retinoblastoma-like 2 (p130) 2 3
MIRT005868 WEE1 WEE1 homolog (S. pombe) 1 1
MIRT006568 EOMES eomesodermin homolog (Xenopus laevis) 1 1
MIRT007004 PURA purine-rich element binding protein A 1 1
MIRT007071 APC adenomatous polyposis coli 3 1
MIRT020417 CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 1 1
MIRT020418 IRF9 interferon regulatory factor 9 1 1
MIRT020419 LINC00483 chromosome 17 open reading frame 73 1 1
MIRT020420 OPRK1 opioid receptor, kappa 1 1 1
MIRT020421 SYT4 synaptotagmin IV 1 1
MIRT020422 GNPDA2 glucosamine-6-phosphate deaminase 2 1 1
MIRT020423 CABP2 calcium binding protein 2 1 1
MIRT020424 DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 1 1
MIRT020425 SSX7 synovial sarcoma, X breakpoint 7 1 1
MIRT020426 KIF23 kinesin family member 23 1 1
MIRT020427 AFP alpha-fetoprotein 1 1
MIRT020428 CD34 CD34 molecule 1 1
MIRT020429 OTP orthopedia homeobox 1 1
MIRT020430 HSP90B3P heat shock protein 90kDa beta (Grp94), member 3 (pseudogene) 1 1
MIRT020431 B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 1 1
MIRT020432 PRB2 proline-rich protein BstNI subfamily 2 1 1
MIRT020433 SBSN suprabasin 1 1
MIRT020434 GPM6A glycoprotein M6A 1 1
MIRT020435 OR52K1 olfactory receptor, family 52, subfamily K, member 1 1 1
MIRT020436 NAGK N-acetylglucosamine kinase 1 1
MIRT020437 KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 1 1
MIRT020438 TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 1 1
MIRT020439 C1orf111 chromosome 1 open reading frame 111 1 1
MIRT020440 TNNI1 troponin I type 1 (skeletal, slow) 1 1
MIRT020441 SPAG1 sperm associated antigen 1 1 1
MIRT020442 SUMF1 sulfatase modifying factor 1 1 1
MIRT020443 RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 1 1
MIRT020444 CASP7 caspase 7, apoptosis-related cysteine peptidase 1 1
MIRT020445 TLR2 toll-like receptor 2 1 1
MIRT020446 SMAD9 SMAD family member 9 1 1
MIRT020447 BTN3A3 butyrophilin, subfamily 3, member A3 1 1
MIRT020448 IFNAR2 interferon (alpha, beta and omega) receptor 2 1 1
MIRT020449 HMGB3 high-mobility group box 3 1 1
MIRT020450 MAT2B methionine adenosyltransferase II, beta 1 1
MIRT020451 ARL13B ADP-ribosylation factor-like 13B 1 1
MIRT020452 DPP9 dipeptidyl-peptidase 9 1 1
MIRT020453 MXI1 MAX interactor 1 2 2
MIRT020454 NUBP1 nucleotide binding protein 1 (MinD homolog, E. coli) 1 1
MIRT020455 NEFH neurofilament, heavy polypeptide 1 1
MIRT020456 COMMD6 COMM domain containing 6 1 1
MIRT020457 KIAA1598 KIAA1598 1 1
MIRT020458 LIN7B lin-7 homolog B (C. elegans) 1 1
MIRT020459 AGO1 eukaryotic translation initiation factor 2C, 1 2 2
MIRT020460 JAK1 Janus kinase 1 1 1
MIRT020461 LIMK1 LIM domain kinase 1 1 1
MIRT020462 KATNAL1 katanin p60 subunit A-like 1 1 1
MIRT020463 ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 1 1
MIRT020464 THAP6 THAP domain containing 6 1 1
MIRT020465 C9orf40 chromosome 9 open reading frame 40 2 2
MIRT020466 PLS1 plastin 1 1 1
MIRT020467 OSTM1 osteopetrosis associated transmembrane protein 1 1 1
MIRT020468 TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 1 1
MIRT020469 AKAP11 A kinase (PRKA) anchor protein 11 1 1
MIRT020470 IFIT5 interferon-induced protein with tetratricopeptide repeats 5 1 1
MIRT020471 CLOCK clock homolog (mouse) 1 1
MIRT020472 ATAD2 ATPase family, AAA domain containing 2 1 1
MIRT020473 TMEM245 chromosome 9 open reading frame 5 1 1
MIRT020474 EIF5A2 eukaryotic translation initiation factor 5A2 1 1
MIRT020475 RORA RAR-related orphan receptor A 1 1
MIRT020476 CROT carnitine O-octanoyltransferase 1 1
MIRT020477 BTG3 BTG family, member 3 1 1
MIRT020478 CDC37L1 cell division cycle 37 homolog (S. cerevisiae)-like 1 1 1
MIRT020479 PON2 paraoxonase 2 1 1
MIRT020480 BRMS1L breast cancer metastasis-suppressor 1-like 1 1
MIRT020481 EFCAB14 KIAA0494 1 1
MIRT020482 HN1 hematological and neurological expressed 1 1 1
MIRT020483 PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 1 1
MIRT020484 USP46 ubiquitin specific peptidase 46 1 1
MIRT020485 PKD2 polycystic kidney disease 2 (autosomal dominant) 1 1
MIRT044246 KANK2 KN motif and ankyrin repeat domains 2 1 1
MIRT044247 TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 1 1
MIRT044248 GON4L gon-4-like (C. elegans) 1 1
MIRT044249 RPL7 ribosomal protein L7 1 1
MIRT044250 PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 1 1
MIRT044251 DGKD diacylglycerol kinase, delta 130kDa 1 1
MIRT044252 APLP2 amyloid beta (A4) precursor-like protein 2 1 1
MIRT044253 ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 1 1
MIRT044254 PATE2 prostate and testis expressed 2 1 1
MIRT044255 CENPM centromere protein M 1 1
MIRT044256 ZC3H18 zinc finger CCCH-type containing 18 1 1
MIRT044257 YTHDF2 YTH domain family, member 2 1 1
MIRT044258 PFDN6 prefoldin subunit 6 1 1
MIRT044259 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 1 1
MIRT044260 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 1 1
MIRT044261 AP1G1 adaptor-related protein complex 1, gamma 1 subunit 1 1
MIRT044262 CLTC clathrin, heavy chain (Hc) 1 1
MIRT044263 SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 1 1
MIRT044264 LARS leucyl-tRNA synthetase 1 1
MIRT044265 TSC1 tuberous sclerosis 1 1 1
MIRT044266 UNC45A unc-45 homolog A (C. elegans) 1 1
MIRT044267 YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 1 1
MIRT044268 SLC10A7 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 1 1
MIRT044269 THADA thyroid adenoma associated 1 1
MIRT044270 RNPS1 RNA binding protein S1, serine-rich domain 1 1
MIRT044271 SLC52A3 chromosome 20 open reading frame 54 1 1
MIRT044272 YBX1 Y box binding protein 1 1 1
MIRT044273 TUBB4B tubulin, beta 2C 1 1
MIRT044274 KIF5C kinesin family member 5C 1 1
MIRT044275 TRIB2 tribbles homolog 2 (Drosophila) 1 1
MIRT044276 WDR33 WD repeat domain 33 1 1
MIRT044277 CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 1 1
MIRT044278 RPS14 ribosomal protein S14 1 1
MIRT044279 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT044280 HSPA1B heat shock 70kDa protein 1B 1 1
MIRT044281 RAD23B RAD23 homolog B (S. cerevisiae) 1 1
MIRT044282 GOLT1B golgi transport 1 homolog B (S. cerevisiae) 1 1
MIRT044283 CNOT6 CCR4-NOT transcription complex, subunit 6 1 1
MIRT044284 ABHD17C family with sequence similarity 108, member C1 1 1
MIRT044285 ZBTB7B zinc finger and BTB domain containing 7B 1 1
MIRT044286 RHOBTB2 Rho-related BTB domain containing 2 1 1
MIRT044287 MTMR1 myotubularin related protein 1 1 1
MIRT044288 IPO7 importin 7 1 1
MIRT044289 PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 1 1
MIRT044290 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT044291 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT044292 ELOVL6 ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) 1 1
MIRT044293 DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 1 1
MIRT044294 RPL21 ribosomal protein L21 1 1
MIRT044295 PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1 1
MIRT044296 SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 1 1
MIRT044297 KMT2D myeloid/lymphoid or mixed-lineage leukemia 2 1 1
MIRT044298 FNBP1 formin binding protein 1 1 1
MIRT044299 HTT huntingtin 1 1
MIRT044300 BRWD1 bromodomain and WD repeat domain containing 1 1 1
MIRT044301 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT044302 MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 1 1
MIRT044303 ZFYVE16 zinc finger, FYVE domain containing 16 1 1
MIRT044304 MSH6 mutS homolog 6 (E. coli) 1 1
MIRT044305 MAT2A methionine adenosyltransferase II, alpha 1 1
MIRT044306 ZNF598 zinc finger protein 598 1 1
MIRT044307 PANK3 pantothenate kinase 3 1 1
MIRT044308 FBXW2 F-box and WD repeat domain containing 2 1 1
MIRT044309 UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 1 1
MIRT044310 ZNF777 zinc finger protein 777 1 1
MIRT044311 PPP4C protein phosphatase 4, catalytic subunit 1 1
MIRT044312 RPL18 ribosomal protein L18 1 1
MIRT044313 NID1 nidogen 1 1 1
MIRT044314 SHISA2 shisa homolog 2 (Xenopus laevis) 1 1
MIRT044315 ZNF562 zinc finger protein 562 1 1
MIRT044316 ZNF587 zinc finger protein 587 1 1
MIRT044317 BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 1 1
MIRT044318 MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 1 1
MIRT044319 RREB1 ras responsive element binding protein 1 1 1
MIRT044320 DAP3 death associated protein 3 1 1
MIRT044321 PPIA peptidylprolyl isomerase A (cyclophilin A) 1 1
MIRT044322 CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 1 1
MIRT044323 UGP2 UDP-glucose pyrophosphorylase 2 1 1
MIRT044324 TXNRD2 thioredoxin reductase 2 1 1
MIRT044325 PTP4A2 protein tyrosine phosphatase type IVA, member 2 1 1
MIRT044326 SLC9A1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 1 1
MIRT044327 CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 1 1
MIRT044328 DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 1 1
MIRT044329 INSIG1 insulin induced gene 1 1 1
MIRT044330 ANAPC7 anaphase promoting complex subunit 7 1 1
MIRT044331 FAM199X family with sequence similarity 199, X-linked 1 1
MIRT044332 TRIP12 thyroid hormone receptor interactor 12 1 1
MIRT044333 RCCD1 RCC1 domain containing 1 1 1
MIRT044334 LRRC59 leucine rich repeat containing 59 1 1
MIRT044335 ANKFY1 ankyrin repeat and FYVE domain containing 1 1 1
MIRT044336 TMPO thymopoietin 1 1
MIRT044337 SETD2 SET domain containing 2 1 1
MIRT044338 TRRAP transformation/transcription domain-associated protein 1 1
MIRT044339 IGDCC3 immunoglobulin superfamily, DCC subclass, member 3 1 1
MIRT044340 CNOT6L CCR4-NOT transcription complex, subunit 6-like 1 1
MIRT044341 UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 1 1
MIRT044342 CES2 carboxylesterase 2 (intestine, liver) 1 1
MIRT044343 HUWE1 HECT, UBA and WWE domain containing 1 1 1
MIRT044344 FAM91A1 family with sequence similarity 91, member A1 1 1
MIRT044345 MIER2 mesoderm induction early response 1, family member 2 1 1
MIRT044346 FAM222B chromosome 17 open reading frame 63 1 1
MIRT044347 SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 1 1
MIRT044348 DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 1 1
MIRT044349 RPP30 ribonuclease P/MRP 30kDa subunit 1 1
MIRT044350 STK40 serine/threonine kinase 40 1 1
MIRT044351 NNT nicotinamide nucleotide transhydrogenase 1 1
MIRT044352 HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1 1
MIRT044353 ZNF706 zinc finger protein 706 1 1
MIRT044354 FAM171A2 family with sequence similarity 171, member A2 1 1
MIRT044355 EIF3F eukaryotic translation initiation factor 3, subunit F 1 1
MIRT044356 KAT7 MYST histone acetyltransferase 2 1 1
MIRT044357 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1 1
MIRT044358 CNOT7 CCR4-NOT transcription complex, subunit 7 1 1
MIRT044359 DCTPP1 dCTP pyrophosphatase 1 1 1
MIRT044360 AP2B1 adaptor-related protein complex 2, beta 1 subunit 1 1
MIRT044361 C6orf120 chromosome 6 open reading frame 120 1 1
MIRT044362 CCDC47 coiled-coil domain containing 47 1 1
MIRT044363 PRMT3 protein arginine methyltransferase 3 1 1
MIRT044364 SPEN spen homolog, transcriptional regulator (Drosophila) 1 1
MIRT044365 ERO1L ERO1-like (S. cerevisiae) 1 1
MIRT044366 HNRNPL heterogeneous nuclear ribonucleoprotein L 1 1
MIRT044367 PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 1 1
MIRT044368 KANSL1 KIAA1267 1 1
MIRT044369 CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1 1
MIRT044370 HMMR hyaluronan-mediated motility receptor (RHAMM) 1 1
MIRT044371 NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 1 1
MIRT044372 FBXO22 F-box protein 22 1 1
MIRT044373 STX12 syntaxin 12 1 1
MIRT044374 MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1 1
MIRT044375 RBM12B RNA binding motif protein 12B 1 1
MIRT044376 RPL18A ribosomal protein L18a 1 1
MIRT044377 TTPAL tocopherol (alpha) transfer protein-like 1 1
MIRT044378 ZBTB39 zinc finger and BTB domain containing 39 1 1
MIRT044379 PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 1 1