Accession ID: MIRT023441 [miRNA, hsa-miR-30b-5p :: GNA13, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-30bLinkOut: [miRBase ]
Description Homo sapiens miR-30b stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-30b-5p
Mature Sequence 17| UGUAAACAUCCUACACUCAGCU |38
Evidence Experimental
Experiments Cloned
Putative hsa-miR-30b-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol GNA13 LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms G13, MGC46138
Description guanine nucleotide binding protein (G protein), alpha 13
Transcript NM_0065    LinkOut: [ RefSeq ]
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on GNA13 LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of GNA13
(miRNA target sites are highlighted)
>GNA13|NM_0065|3'UTR
   1 TGATGTACAAAAGACTTGCTGTTTTAATATCTTTTTGTGTTTTTGATGTTTTCTGTTTGTTTTGTTTTTTAAAATAGCAG
  81 TTTACAACCAGAATTAGAACAATCTTAATTCTACGTTTAACTTCTTGAAAATCTTAGTACTTTTTCTGCGGCCTTTGGTT
 161 TGTGGCTGAAAGCTGTTGAGTGACTCATCGCCAAGATTTGCTGTAATGCAGGCTTTGATCTGTTTCACCATGGCTTCTAT
 241 TCAAGTCCAGTTAAAACCTCCCAGCTGACCTCAGACTAGGCATATTTCAGGCTTTAAATTATTCTACTTTCCAAACTGAA
 321 TTCTCCTGCAGTGCCAAGTATCAAAGGTGTCCTTAAATACTTGTAGGGATGAGGTTAGGAATATTCAGTTCCAAAACAAG
 401 ATATCTTCTGTCCGCCTTACATATAGCAGTGACACTTGTTGCCTAACTTTATGGTGACCTCCTATTTTGTAAGGGCTGTT
 481 AGAAGTTCTATCTAAGAAATGGCATTCTGTAGGTTTATAGAAGGTTTAGCCTTCATATTTTAATTGCTTGTATACACAAC
 561 AGCTGTTTTGCTTTTAGATTTCTGTGTTTCTGAAGGTAATGTTCTTCCTGTTTTCAAGTTTACATAAGGATCTTTGGTCT
 641 GATGCTGATGAAGAGTTCACAGGTGGTATGGGAGAGCAAAAGGCAAGCTAATGCTGTTTACCGTGTTTTGGTCAAACGTA
 721 ACGAGTGAAATAGAATTTGCCTTTCTCATATTTAATTATCATGTAGTTTAATGTACCATATGTGAAACATTCTGGCCATA
 801 GCAGCAACTAAAAACTGCAAGCAACTTGGTAACAGAACTTTCTAAATAAACTTAACCTGTTCCAGAATGTCATGTATTTG
 881 ACTTTTAAGCCCTATCTCAGTTGGTCAGTAAAGACCAATCCTTACTGTAGGAAATCATTGTTGTATCATCACAAACATCT
 961 ATCTTTTGCTGTCCTGTCCAGTCCCATCAACTCCACACTGTGCCATTTGTGGCATCGTTTTGTTTATTTGGAGTTTGCTA
1041 AGGGCAGTATTTTTCTGTCAAGACTATTCAAGAAGGCATTATTTGAGATTCCTGTTCATTCTTGGTGTGTCTCTAACAGA
1121 TACAGTATGTATACATTTGTATAATTGTTGTTGTTGAAAGTCCAGCTTTTTTGAGGTATATTTTAAATGTTTTAAGGATG
1201 CTTCTAAGGATCAGTAGTAATTTTTTTAGTTCGCACCTAAAGATGATTACATTGACCTCCCCCGACTGCTTACCAAATTA
1281 AAATGTGTCCACGAAGTAGCTTTGTGATCGCAGATACATTCATAGTGAACTCATCAGAATGGCTGGTTTGCAGTACTGAA
1361 ATACTATCTTCTAGGCTGTATGTAGTGCTACAATTAGAGAAACAGAAGTCCAAGGCTGGCGACAGCTTGAAAAGTCTGAC
1441 AGCTTTTCTACTTTTCCTGAAAATTTTAAGACTGTGATATCTGTCATTTTACTGTATAGCTGACTGTGTACTCAGGTATT
1521 TTATTGGTCCTTGAAAGATTGGTCGTTATGGATCACCCAGCCTTTCCAAGTCAGTGGCTGTTGTTCTGTCTTGCTGTCTG
1601 ATACGAGAGTGGGGCTTTTCAGTGAACTAACCAGGGATTGTTCTTGACATACCTGACTTTTCTCACATTTGAACTTCCAC
1681 TATCATTGTATCCATATAACTTCTAGCATTTTCATGCCATGGTAATCCATGAGCTACACATACGTAGCCCGGCACCGTGA
1761 TGCAAGTTCATGGTATCGTGCATGTTCGTGGTATCATGGTATCATTCATGCGTGTTTGAATAGTTCTACATCTAGTGCTT
1841 CTTGCCAAAAAGAATACATTGTTTAAATTCACAAAATTAGCATAATTGCAGTGCTAATGAATATCGGAATATGTGCACAG
1921 TAACATTTGGACTATTCATTGGAGAGTTTACCCATACATTTAGCAAATTGAATGGCCAAAACATTTGACTCCAGTGAGGG
2001 CTCAAGTTAGATCCCTATAGAAAGAGGACACTTCATCTTACTTAAGTCATAGTTAAGATCTGTGATACGAACCATAGATA
2081 TTGCCTGACAAAGCAGAAATCACCAAGTTTCCCCCTTTTGAATTACCACCAAGAAGTGTTGAAACACCAAATAGATATCA
2161 TGTTATTTTGGGCATTTGCAGTTTTCTTCCCTGCTGCATGTAATGTCTCAGAATCAACATTCTTTTAAAATCTAGACTAT
2241 ATTTTGAGGCAATGAATTACTTATATTCAACTTAGGCTTGTTTTGACATTCAGTAGAACTTTAAGTTCAATCTAAAGGCT
2321 TCAGTCCACATTTTTTTATACGTTGTATTTTAAAAACGTTTGAAAGGAGTCTTACACCTGTATCATGAAAACTGAATCCT
2401 TTTGAAATACCACTATATGAAGAGAGAGATGAAATTTAGTGAACAGAATTGAAAAGGTGCTCATAATTTCACTATGCAAA
2481 CTTACCCCAGTCTCTAAAAAAGTAATTTAGATTTAAAGTTCTTTGATGTATTTGATTTTCTAAATCTTTATGGTTATGAT
2561 TTGGAATAAAATGTGCCTAATCCTGTGTTACATTCTGTTCTTAAATCTGAATGCCTTCTCATTTAATTCTGAGGAAATAT
2641 CACACAAGTGTCTTCATTGACCTTGAAGAAATGTATATACAGTTGCCTTATAAAACAACATAAATTTAGACCATAACTTT
2721 TATAGAGAAAGGGTTTTGTCAAATGTTTTCTGAAAATCTGAGTAATTCAAAGCATGCCTCTGCCCCTTTAATATTTTTAA
2801 TAACCTGCATTGTTGCTGTCTGCCAAATATTAAATTGAAATCTTCATTTCAATTTTATTATCTGGAAAGGGCACTGGATT
2881 GCTCTGCAACCAAAGAAAGCAATATGGAATGAAAAAACTCATTCACTTTTGTCTTATTTTCTTTTAAGGTGTATTGGCAT
2961 GTAATTTGCATAGAGAAGGTCCTCTGGTTAGTCTCTCAAATTGAGGCTGTTTAGGGAAATCCTTATTCAGTTGGTGGCAG
3041 TGGTTGGTTTAAAGTAGAAGGAAATAAGATCGCCTTAATACCAGAAATGATTAGAAGTGCTGATTTAGATTCAACAAATA
3121 CCATATGTCCTTATCATTTTTTGTAAGAAGAAATTGGTTAAGTCCTAACTTTCAATGTGTACCCAAATACTTGTATTTAT
3201 GCTTTTGATAAAATGTATTTTCAGCATTAATACACATCCGATTATGCCTTATTTATATATGAAGAATAAAGTTACCATGT
3281 TATACTGTTATGTCCTAAAATTCAAATCACTATTTGAGAAACCCTCAAATTGGTGCTTTCATTATATAATGATACATTTA
3361 GACAAAACCCCAAACTAAGCCATTTGAAACAAGATTCTCTCCATTGCAGTTTGTAGCAATGTTATTTCTGTGTATGTCAT
3441 GAGAAGGCTAAATATCAGTGTTAATTTCTTGTTTGAATCCGTGAAATCATGCCTGTAAAGCCCAAACATTTGTAACAAAC
3521 TCCCTAATAAATTTAGAGAAAGTCACTCTGTTACCATTTCATTTATTTTAGTTTTATTTGAGAAATTAAGACCAGAAGTT
3601 TTGCTCATGTCTTTTTCACTTGGAAATCTGACTTAGTACCTAGTTAATTTGTCTCTCTCCCATCATTTTAAGGCGTTCGC
3681 TTCTGTTAATCACAGATGATCTGTCCTTGTGTTGTGCTGCTTGACTAAAAGCACTGTTTTGTTTTGTTTTGTTTTGTTTT
3761 TTAATGATAGGATACAGGGTGGCTTTTCAGTCTAGTAAACATGAGGAGGGGAGAGATTGTGGGTGGGTGTGGGTGTGTCC
3841 GCATGTCCCAAATACAGCACATGCCCATTTTTTTATGGTACGAGGTTAGGGCTTATTAATAAATGTATACTAGATCTTGA
3921 AGTGTAAGTCTAAGTCTGAACATTTTAAACAAGTTGGACTTTATGGCTTTTTCAAGTTCCATCAAGTAGATACTAGTCTT
4001 AGGCTGGTAGGTGATTAACAACATCATTTGGAGTACAGTGTTTGTACCACTAGCATTCTTATGTCTGTACTTGAACGTGT
4081 AGTTAGCATTTAAGTTATGTTCACTCTTGTAGCATTCAGGTCTTACCATCTGGTTTCAAATGCGAGAGCTTATATGAACA
4161 TTGTTTTGAAAGCATGAATGATATGGCAATATTTTATGTCTTGATAAGGAGAGTTTTGTGACATATACAAATCTGCTGTT
4241 GATGATGAAAGTTTACAGGTGGATCAGAGTATGCTGGAACTCAGTGTGCATAAAATTTCAGTCAGTGAATATCACTGAAC
4321 GTCATATACTACTTGGTATGTGACTTTGGTTTGTGTTAAGAAAGCTTGTATATAATATTTTTTGCCATAGTAAGTGAGAA
4401 ATTGTCCTTAATCATGCCTGTTTGATGGTACTAGGAAAGAAAGGGGTAGAGATTAATTCTTGCACAGTATAAGCAACAGT
4481 GCAACAAACTATGCCATTTACCTTTTACCTCTTACTTGAAGGCAGAATCGCAAAACGTTTGAAATGGCTTTTCTAAACTA
4561 CTCTACTCTGGTGAGAGCTCATTTACCACAAGAAGCCTTATAAAAAAGTATATTTTGTAATAACCCCGTAGATACTGTAC
4641 CTAACAAAACATGACTCGTATTAGCTCTATAAAATATTTGTGGCTTAGGATTTTTTTTTTACATATATCTTTTTATAACT
4721 TTCCAGGAACTAAGCACATTATCTGATAATTGTTGTAAATTTTTTTGTCAGTGCTTTAGTTCAGGATGGGCAATAAATTA
4801 TTTCTAAAGGAGGTCTAAAAGTGGAAAGAATGGTTTGATTTTATAAAATGAGTTGCTAGTTCATTACAGCTTTTTACTTT
4881 TGTACATATTTTGCAAAACATTTGCCTCTTGCTATTAATATTTGCTTTGTAAAAATTACTGACATTTAATAAACATTTGT
4961 AAACAATTCAA
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' ucgacUCACAUCCUACAAAUGu 5'
               ||   | | ||||||| 
Target 5' aggcaAGCTAATGCTGTTTACc 3'
681 - 702 145.00 -5.60
2
miRNA  3' ucgacUCACAUCCUACAAAUgu 5'
               | || ||| ||||||  
Target 5' ctcaaATTG-AGGCTGTTTAgg 3'
2995 - 3015 136.00 -7.39
3
miRNA  3' ucGACUCACAUCCUACAAAUGu 5'
            :|| || |  ||||||| | 
Target 5' ttTTGTGTTTTTGATGTTTTCt 3'
33 - 54 132.00 -8.12
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-30b-5p :: GNA13    [ Functional MTI ]
Validation Method Sequencing
Article - Hafner, M. Landthaler, M. Burger, L. et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
MiRNA-Target Expression Profile:

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
126 hsa-miR-30b-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006303 CCNE2 cyclin E2 2 1
MIRT006320 SMAD1 SMAD family member 1 2 1
MIRT006324 BCL6 B-cell CLL/lymphoma 6 3 1
MIRT006325 SOCS1 suppressor of cytokine signaling 1 3 1
MIRT006610 Snai1 snail homolog 1 (Drosophila) 2 1
MIRT006761 SNAI1 snail homolog 1 (Drosophila) 3 1
MIRT007067 CAT catalase 3 1
MIRT023404 KLHL28 kelch-like 28 (Drosophila) 1 1
MIRT023405 USP53 ubiquitin specific peptidase 53 1 1
MIRT023406 CHD1 chromodomain helicase DNA binding protein 1 1 1
MIRT023407 COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) 1 1
MIRT023408 MYO1E myosin IE 1 1
MIRT023409 RGMB RGM domain family, member B 1 1
MIRT023410 FBXO3 F-box protein 3 1 1
MIRT023411 SRPR signal recognition particle receptor (docking protein) 1 1
MIRT023412 BLOC1S6 pallidin homolog (mouse) 1 1
MIRT023413 PLIN3 perilipin 3 1 1
MIRT023414 KBTBD6 kelch repeat and BTB (POZ) domain containing 6 1 1
MIRT023415 ZNF543 zinc finger protein 543 1 1
MIRT023416 ZFYVE20 zinc finger, FYVE domain containing 20 1 1
MIRT023417 FAM8A1 family with sequence similarity 8, member A1 1 1
MIRT023418 NCOA6 nuclear receptor coactivator 6 1 1
MIRT023419 TRERF1 transcriptional regulating factor 1 1 1
MIRT023420 ZNF567 zinc finger protein 567 1 1
MIRT023421 DCAF12 DDB1 and CUL4 associated factor 12 1 1
MIRT023422 CLDN12 claudin 12 1 1
MIRT023423 PNN pinin, desmosome associated protein 1 1
MIRT023424 WDR89 WD repeat domain 89 1 1
MIRT023425 PHF13 PHD finger protein 13 1 1
MIRT023426 RRAGD Ras-related GTP binding D 1 1
MIRT023427 ZBTB38 zinc finger and BTB domain containing 38 1 1
MIRT023428 PDCD10 programmed cell death 10 1 1
MIRT023429 ZNF770 zinc finger protein 770 1 1
MIRT023430 NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1 1
MIRT023431 FRZB frizzled-related protein 1 1
MIRT023432 METTL21D chromosome 14 open reading frame 138 1 1
MIRT023433 ZDHHC17 zinc finger, DHHC-type containing 17 1 1
MIRT023434 CDCA7 cell division cycle associated 7 1 1
MIRT023435 HIC2 hypermethylated in cancer 2 1 1
MIRT023436 OTUD4 OTU domain containing 4 1 1
MIRT023437 GLCE glucuronic acid epimerase 1 1
MIRT023438 SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 1 1
MIRT023439 ARID3A AT rich interactive domain 3A (BRIGHT-like) 1 1
MIRT023440 AZIN1 antizyme inhibitor 1 1 1
MIRT023441 GNA13 guanine nucleotide binding protein (G protein), alpha 13 1 1
MIRT023442 NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1 1
MIRT023443 CD2AP CD2-associated protein 1 1
MIRT023444 TNRC6C trinucleotide repeat containing 6C 1 1
MIRT023445 SOX4 SRY (sex determining region Y)-box 4 1 1
MIRT023446 EML4 echinoderm microtubule associated protein like 4 1 1
MIRT023447 AP2A1 adaptor-related protein complex 2, alpha 1 subunit 1 1
MIRT023448 ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 1 1
MIRT023449 SYPL1 synaptophysin-like 1 1 1
MIRT023450 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 1 1
MIRT023451 PGM3 phosphoglucomutase 3 1 1
MIRT023452 DDAH1 dimethylarginine dimethylaminohydrolase 1 1 1
MIRT023453 SH2B3 SH2B adaptor protein 3 1 1
MIRT023454 RFX7 regulatory factor X, 7 1 1
MIRT023455 KLF10 Kruppel-like factor 10 1 1
MIRT023456 YOD1 YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) 1 1
MIRT023457 GNPDA1 glucosamine-6-phosphate deaminase 1 1 1
MIRT023458 TAOK1 TAO kinase 1 1 1
MIRT023459 GFPT2 glutamine-fructose-6-phosphate transaminase 2 1 1
MIRT023460 B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 1 1
MIRT023461 MIER3 mesoderm induction early response 1, family member 3 1 1
MIRT023462 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 1 1
MIRT046108 CAMKV CaM kinase-like vesicle-associated 1 1
MIRT046109 IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1 1
MIRT046110 KLF4 Kruppel-like factor 4 (gut) 1 1
MIRT046111 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1 1
MIRT046112 TSHZ3 teashirt zinc finger homeobox 3 1 1
MIRT046113 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 1 1
MIRT046114 BAZ1B bromodomain adjacent to zinc finger domain, 1B 1 1
MIRT046115 RUNX2 runt-related transcription factor 2 1 1
MIRT046116 NIPBL Nipped-B homolog (Drosophila) 1 1
MIRT046117 FEM1B fem-1 homolog b (C. elegans) 1 1
MIRT046118 WDR43 WD repeat domain 43 1 1
MIRT046119 STX17 syntaxin 17 1 1
MIRT046120 IKZF4 IKAROS family zinc finger 4 (Eos) 1 1
MIRT046121 CSF1 colony stimulating factor 1 (macrophage) 1 1
MIRT046122 POLRMT polymerase (RNA) mitochondrial (DNA directed) 1 1
MIRT046123 CHAT choline O-acetyltransferase 1 1
MIRT046124 CEP152 centrosomal protein 152kDa 1 1
MIRT046125 FERMT2 fermitin family homolog 2 (Drosophila) 1 1
MIRT046126 HEY1 hairy/enhancer-of-split related with YRPW motif 1 1 1
MIRT046127 RAB18 RAB18, member RAS oncogene family 1 1
MIRT046128 OLFML2B olfactomedin-like 2B 1 1
MIRT046129 RBBP7 retinoblastoma binding protein 7 1 1
MIRT046130 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT046131 MATR3 matrin 3 1 1
MIRT046132 RPS4X ribosomal protein S4, X-linked 1 1
MIRT046133 EYA3 eyes absent homolog 3 (Drosophila) 1 1
MIRT046134 APLN apelin 1 1
MIRT046135 G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1 1
MIRT046136 RAB22A RAB22A, member RAS oncogene family 1 1
MIRT046137 PARP1 poly (ADP-ribose) polymerase 1 1 1
MIRT046138 TMED5 transmembrane emp24 protein transport domain containing 5 1 1
MIRT046139 EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1 1
MIRT046140 ACER3 alkaline ceramidase 3 1 1
MIRT046141 WDR37 WD repeat domain 37 1 1
MIRT046142 CYB5B cytochrome b5 type B (outer mitochondrial membrane) 1 1
MIRT046143 HMGN2 high-mobility group nucleosomal binding domain 2 1 1
MIRT046144 ACTR10 actin-related protein 10 homolog (S. cerevisiae) 1 1
MIRT046145 KLHL15 kelch-like 15 (Drosophila) 1 1
MIRT046146 C1QBP complement component 1, q subcomponent binding protein 1 1
MIRT046147 PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B 1 1
MIRT046148 FAM134C family with sequence similarity 134, member C 1 1
MIRT046149 RNF34 ring finger protein 34 1 1
MIRT046150 TRIM59 tripartite motif-containing 59 1 1
MIRT046151 TMEM106B transmembrane protein 106B 1 1
MIRT046152 MCFD2 multiple coagulation factor deficiency 2 1 1
MIRT046153 RPS27A ribosomal protein S27a 1 1
MIRT046154 SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 1 1
MIRT046155 ZNF589 zinc finger protein 589 1 1
MIRT046156 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1 1
MIRT046157 TTLL12 tubulin tyrosine ligase-like family, member 12 1 1
MIRT046158 ZNF646 zinc finger protein 646 1 1
MIRT046159 GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 1 1
MIRT046160 ARF1 ADP-ribosylation factor 1 1 1
MIRT046161 RBM14 RNA binding motif protein 14 1 1
MIRT046162 SKIL SKI-like oncogene 1 1
MIRT046163 DNMT1 DNA (cytosine-5-)-methyltransferase 1 1 1
MIRT046164 PRMT7 protein arginine methyltransferase 7 1 1
MIRT046165 POU4F1 POU class 4 homeobox 1 1 1
MIRT046166 PCNT pericentrin 1 1
MIRT046167 ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 1 1