Accession ID: MIRT039217 [miRNA, hsa-miR-769-5p :: FKRP, target gene]
pre-miRNA Information
pre-miRNA ID hsa-mir-769LinkOut: [miRBase ]
Synonyms MIRN769, hsa-mir-769, MIR769
Description Homo sapiens miR-769 stem-loop
2nd Structure of pre-miRNA
Disease
Mature miRNA Information
Mature miRNA hsa-miR-769-5p
Mature Sequence 30| UGAGACCUCUGGGUUCUGAGCU |51
Evidence Experimental
Experiments Cloned
Putative hsa-miR-769-5p Targets LinkOut: [ TargetScanS 5.1 | MicroCosm | microRNA.org | miRecords | miRDB | miRo | miRNAMap 2.0 ]
Gene Information
Gene Symbol FKRP LinkOut: [ Entrez Gene | BioGPS | Wikipedia | iHop ]
Synonyms LGMD2I, MDC1C, MDDGA5, MDDGB5, MDDGC5
Description fukutin related protein
Transcript NM_001039885    LinkOut: [ RefSeq ]
Other Transcripts NM_024301   
Expression LinkOut: [ BioGPS ]
Putative miRNA Targets on FKRP LinkOut: [ TargetScan 5.1 | MicroCosm | miRNAMap 2.0 ]
3'UTR of FKRP
(miRNA target sites are highlighted)
>FKRP|NM_001039885|3'UTR
   1 AGCCCTGATAACCTCGCCTTTGTTTTTCGGGGGTCTGTCTGGATGTGGAGAAGCTCTGTGTGAGCGGTGAGGGGTGGAGG
  81 GATGTCGCGGAGAGGGGAAGGGGGAAACTGACCAAGAAAGAAATTCTAAGGAGAGCATGAGAGAAGGCTGGCATTGGCAG
 161 GAGGAGAGCACCAGGACGAGGATGGGAAGCGACCTCCAGATTTATCAAATGGTCATGCCCACTGGGAGCCGTGGATATGC
 241 GTGGGGACATCCTGGGTCATCTCAGTCATGGAGGGAGACGGGGATGTCACGCCGTCCCGCAGGGCCCAGCACAGCCCCAG
 321 ACCCGAAAAAAGTGTTCTGCCCAAGATTCCGAGAGCCCTGCGCTCTAGGGCAGGGGCAGAGTTTTGGAAACAGTGCAGGC
 401 TCTGGAGCCAGACTGGCGAGATTCAAATCCTGGCTCTATCGCTTCGGAGCCAGGTGGGCCTGGGGGGGCGTCGCAGTCTC
 481 TCTGTGCCTCAGTTGCTTCCAGGATGCGGGACCCTTGGCTGCAGGGGTTGCTTCCGCCACTAGAGGGCGCGCCGGTCCCG
 561 CTCCTGGTGGCCCACTGTGGCTGCCCGGGCGACAGTACGCCCAGGGCCTGTGTTCCATAGCCATCTACTCTCTTGAGCCT
 641 TTGGACTTCTCTCCAAGCCCCTGTGGGAGGCGGACAGCAGTGACCACCTCCCCTTCTTTTGGACTGCGACCTCCTTCCCT
 721 CCTGGGAGAGCCCTGTGACCTGCATGCTACTCTTAACTGTTCTATTCAAGACTGAATAGAAGTATTTCAGTCTTGCAGAG
 801 GAGGAAATGCTCAGAGCTCCGAGGTGCGGCTGTGGTCGAGAACCGGGTGCTGGGCCGGGCGCGGGGGCTCACGCCTGTAA
 881 TCCCAGCACTTTGGGAGGCCGAGGTGGGAGGATCGCTTGAGCCCAGGAGTCTGAGACCAGCCTCGGCAACATGCCAAGAC
 961 CCCGTCTCTATTTTTAAAAAAGAAAAAGAACCGACTTCTGAATCGCAGCTCCACTCATGACTAATACCTCATTATTTCAG
1041 CTGTCTGCACCTAATTCCCCACTTGCACGGCAGTGTAGACAATAACCATAGCTCACACTCACTGAGCACCTACTGGGTAC
1121 CAGGCACCATTCTCAGTGTTTCACCTGGATCAACTAATGCGTCCCTCACCTCAGCCCTCTGAAGTGACAGCTGCTATTAT
1201 TTTCATTACACAGATGAAAAAGCTGAGGCCAGAATCGTGAAGTCACTTGCTCAAGGTCAGGCAGCTTAGGAAGGGGCAGA
1281 TCGGGGGCTTGAACCCAGGTGGTCAGGCTCTGGAGCCCACAATTGTCTTACCCACTATGCCCCTCTCTAGTCATGGTCCC
1361 CAAGAGGGGCTTGGAGACCCACTTAGCAGGTGAAAGCAATGGCAGCCTTCCTTATTTGATTATGCACCTAAGAATAAATG
1441 GTATTTGGGCATGTATTCCCAATATGTGTATATTTATTTATAAATATATACAGATACTATTATCTGTATGTTAGTAATAA
1521 AGCTTAAATTATTCCATTTTAAAATTATGAATATGAATAGGGTTTTTTTTATGTTTCTTGCCTCATCCCAATGACTTTTG
1601 CACACCCAGGTGTGAGCACCCAGCATTCAAGACCACG
Target sites Provided by authors  Predicted by miRanda
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' ucGAGUCUUGGGUCUCCAgagu 5'
            ||||||:|:| |||||    
Target 5' tgCTCAGAGCTCCGAGGTgcgg 3'
808 - 829 124.00 -25.70
2
miRNA  3' ucgagucuuGGGUCUCCAGAgu 5'
                   ::|:|:|||||  
Target 5' cctttgtttTTCGGGGGTCTgt 3'
17 - 38 117.00 -15.10
3
miRNA  3' ucGAGUCUUGGGUC------UCC-AGAgu 5'
            ||: ||||||||      ||| |||  
Target 5' ggCTT-GAACCCAGGTGGTCAGGCTCTgg 3'
1286 - 1313 113.00 -23.01
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target hsa-miR-769-5p :: FKRP    [ Functional MTI ]
Validation Method CLASH
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak, A. Kudla, G. Dudnakova, T. Tollervey, D., 2013, Cell.

Article - Helwak, A. Kudla, G. Dudnakova, T. Tollervey, D.
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile:

 
MiRNA-Target Expression Profile(TCGA):

 
MiRNA-Target Interaction Network:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR)
Other evidence
198 hsa-miR-769-5p Target Genes:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004869 TRAPPC2P1 trafficking protein particle complex 2 pseudogene 1 2 1
MIRT016090 PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1 1
MIRT016091 SCP2 sterol carrier protein 2 1 1
MIRT016092 FAM126B family with sequence similarity 126, member B 1 1
MIRT016093 TAOK2 TAO kinase 2 1 1
MIRT016094 HIC2 hypermethylated in cancer 2 1 1
MIRT016095 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 1
MIRT016096 ATF7 activating transcription factor 7 1 1
MIRT016097 CKAP2L cytoskeleton associated protein 2-like 1 1
MIRT016098 RGMB RGM domain family, member B 1 1
MIRT016099 PTPN9 protein tyrosine phosphatase, non-receptor type 9 1 1
MIRT039138 FBXO45 F-box protein 45 1 1
MIRT039139 CLYBL citrate lyase beta like 1 1
MIRT039140 ATP11A ATPase, class VI, type 11A 1 1
MIRT039141 FANCD2 Fanconi anemia, complementation group D2 1 1
MIRT039142 ILF3 interleukin enhancer binding factor 3, 90kDa 1 1
MIRT039143 IGSF3 immunoglobulin superfamily, member 3 1 1
MIRT039144 PARP6 poly (ADP-ribose) polymerase family, member 6 1 1
MIRT039145 MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1 1
MIRT039146 NCSTN nicastrin 1 1
MIRT039147 ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 1 1
MIRT039148 PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 1 1
MIRT039149 NDE1 nudE nuclear distribution E homolog 1 (A. nidulans) 1 1
MIRT039150 GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 1 1
MIRT039151 H2AFY2 H2A histone family, member Y2 1 1
MIRT039152 KIAA1211 KIAA1211 1 1
MIRT039153 LPIN2 lipin 2 1 1
MIRT039154 RPL14 ribosomal protein L14 1 1
MIRT039155 AK1 adenylate kinase 1 1 1
MIRT039156 ZC3H14 zinc finger CCCH-type containing 14 1 1
MIRT039157 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1 1
MIRT039158 TMEM165 transmembrane protein 165 1 1
MIRT039159 AKAP2 A kinase (PRKA) anchor protein 2 1 1
MIRT039160 CNOT6 CCR4-NOT transcription complex, subunit 6 1 1
MIRT039161 MAPK1 mitogen-activated protein kinase 1 1 1
MIRT039162 NCLN nicalin 1 1
MIRT039163 WDR18 WD repeat domain 18 1 1
MIRT039164 NABP2 nucleic acid binding protein 2 1 1
MIRT039165 KDM2A lysine (K)-specific demethylase 2A 1 1
MIRT039166 SPEN spen homolog, transcriptional regulator (Drosophila) 1 1
MIRT039167 RNF40 ring finger protein 40, E3 ubiquitin protein ligase 1 1
MIRT039168 CREBBP CREB binding protein 1 1
MIRT039169 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 1 1
MIRT039170 GGPS1 geranylgeranyl diphosphate synthase 1 1 1
MIRT039171 ARL1 ADP-ribosylation factor-like 1 1 1
MIRT039172 ADPGK ADP-dependent glucokinase 1 1
MIRT039173 PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1 1
MIRT039174 NBPF15 neuroblastoma breakpoint family, member 15 1 1
MIRT039175 WDR62 WD repeat domain 62 1 1
MIRT039176 LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1 1
MIRT039177 ACTN4 actinin, alpha 4 1 1
MIRT039178 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1 1
MIRT039179 TRMT61A tRNA methyltransferase 61 homolog A (S. cerevisiae) 1 1
MIRT039180 HELLS helicase, lymphoid-specific 1 1
MIRT039181 DPH5 DPH5 homolog (S. cerevisiae) 1 1
MIRT039182 EIF5A eukaryotic translation initiation factor 5A 1 1
MIRT039183 PKM pyruvate kinase, muscle 1 1
MIRT039184 FAM49B family with sequence similarity 49, member B 1 1
MIRT039185 HIST2H4B histone cluster 2, H4b 1 1
MIRT039186 CTC1 CTS telomere maintenance complex component 1 1 1
MIRT039187 RPRD2 regulation of nuclear pre-mRNA domain containing 2 1 1
MIRT039188 SPAG5 sperm associated antigen 5 1 1
MIRT039189 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1 1
MIRT039190 GSE1 Gse1 coiled-coil protein homolog (mouse) 1 1
MIRT039191 TRIM59 tripartite motif containing 59 1 1
MIRT039192 EIF4E eukaryotic translation initiation factor 4E 1 1
MIRT039193 GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1 1
MIRT039194 BARX2 BARX homeobox 2 1 1
MIRT039195 BCAT1 branched chain amino-acid transaminase 1, cytosolic 1 1
MIRT039196 TFRC transferrin receptor (p90, CD71) 1 1
MIRT039197 PRUNE2 prune homolog 2 (Drosophila) 1 1
MIRT039198 SCML2 sex comb on midleg-like 2 (Drosophila) 1 1
MIRT039199 SPIRE1 spire homolog 1 (Drosophila) 1 1
MIRT039200 TSKU tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) 1 1
MIRT039201 CAPNS1 calpain, small subunit 1 1 1
MIRT039202 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT039203 LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1 1
MIRT039204 MTG2 GTP binding protein 5 (putative) 1 1
MIRT039205 MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 1 2
MIRT039206 GLA galactosidase, alpha 1 1
MIRT039207 FOXK2 forkhead box K2 1 1
MIRT039208 DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 1 1
MIRT039209 UBQLN4 ubiquilin 4 1 1
MIRT039210 PRDX4 peroxiredoxin 4 1 1
MIRT039211 BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 1 1
MIRT039212 TCERG1 transcription elongation regulator 1 1 1
MIRT039213 QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1 1
MIRT039214 INTS1 integrator complex subunit 1 1 1
MIRT039215 SRSF4 serine/arginine-rich splicing factor 4 1 1
MIRT039216 FAM21B family with sequence similarity 21, member B 1 1
MIRT039217 FKRP fukutin related protein 1 1
MIRT039218 TMEM97 transmembrane protein 97 1 1
MIRT405266 ZNF678 zinc finger protein 678 1 1
MIRT444839 PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 1 1
MIRT444909 KIAA1841 KIAA1841 1 1
MIRT445788 ALG13 asparagine-linked glycosylation 13 homolog (S. cerevisiae) 1 1
MIRT447404 PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 1 1
MIRT447648 RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 1 1
MIRT447661 SLC7A6OS solute carrier family 7, member 6 opposite strand 1 1
MIRT448709 KLHL11 kelch-like 11 (Drosophila) 1 1
MIRT450329 LRWD1 leucine-rich repeats and WD repeat domain containing 1 1 1
MIRT450750 POLI polymerase (DNA directed) iota 1 2
MIRT451673 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 1 1
MIRT452764 TCEA3 transcription elongation factor A (SII), 3 1 2
MIRT455626 PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 1 5
MIRT455637 PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 1 5
MIRT457851 ZNF324B zinc finger protein 324B 1 1
MIRT459844 HEATR3 HEAT repeat containing 3 1 1
MIRT460855 TBC1D19 TBC1 domain family, member 19 1 1
MIRT466105 TMEM170B transmembrane protein 170B 1 1
MIRT467601 SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 1 1
MIRT471740 OSBPL2 oxysterol binding protein-like 2 1 1
MIRT472944 MSMO1 methylsterol monooxygenase 1 1 2
MIRT475032 JOSD1 Josephin domain containing 1 1 1
MIRT476024 GSPT1 G1 to S phase transition 1 1 2
MIRT483973 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 1 1
MIRT484663 HOXD3 homeobox D3 1 2
MIRT485419 LZIC leucine zipper and CTNNBIP1 domain containing 1 4
MIRT491019 LRPPRC leucine-rich pentatricopeptide repeat containing 1 5
MIRT491171 LRP3 low density lipoprotein receptor-related protein 3 1 1
MIRT493990 EHD1 EH-domain containing 1 1 1
MIRT512140 COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 1 1
MIRT513133 ZNF431 zinc finger protein 431 1 1
MIRT514244 ZNF573 zinc finger protein 573 1 1
MIRT514254 S1PR2 sphingosine-1-phosphate receptor 2 1 1
MIRT515301 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 1 2
MIRT517284 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1 2
MIRT520261 URGCP upregulator of cell proliferation 1 1
MIRT521683 PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 1 1
MIRT522124 NELL2 NEL-like 2 (chicken) 1 1
MIRT524490 CEP97 centrosomal protein 97kDa 1 1
MIRT525120 ZNF665 zinc finger protein 665 1 1
MIRT526010 RBM4B RNA binding motif protein 4B 1 1
MIRT529797 ZDHHC8 zinc finger, DHHC-type containing 8 1 1
MIRT531708 TFEC transcription factor EC 1 1
MIRT532231 KLF2 Kruppel-like factor 2 (lung) 1 1
MIRT533077 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 1
MIRT535324 PHACTR4 phosphatase and actin regulator 4 1 1
MIRT539742 SH3RF2 SH3 domain containing ring finger 2 1 1
MIRT540453 PEX26 peroxisomal biogenesis factor 26 1 1
MIRT540546 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 1 2
MIRT541733 ZC3HAV1 zinc finger CCCH-type, antiviral 1 1 1
MIRT542002 XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 1 1
MIRT542016 PEX2 peroxisomal biogenesis factor 2 1 1
MIRT542364 PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1 1
MIRT542489 WDR13 WD repeat domain 13 1 1
MIRT542565 ZNF280B zinc finger protein 280B 1 1
MIRT548094 GFPT1 glutamine--fructose-6-phosphate transaminase 1 1 2
MIRT559654 AHCYL2 adenosylhomocysteinase-like 2 1 1
MIRT561467 TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 1 1
MIRT562722 ZNF714 zinc finger protein 714 1 1
MIRT563041 NBPF12 neuroblastoma breakpoint family, member 12 1 1
MIRT570074 VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 1 1
MIRT606812 BICD2 bicaudal D homolog 2 (Drosophila) 1 1
MIRT608654 ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 1 1
MIRT610110 IL17REL interleukin 17 receptor E-like 1 1
MIRT636051 ZSCAN29 zinc finger and SCAN domain containing 29 1 2
MIRT639208 RAD51 RAD51 homolog (S. cerevisiae) 1 1
MIRT663657 ZNF486 zinc finger protein 486 1 2
MIRT663953 ZNF554 zinc finger protein 554 1 1
MIRT665662 TRAF1 TNF receptor-associated factor 1 1 1
MIRT667138 NT5DC3 5'-nucleotidase domain containing 3 1 1
MIRT672414 SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 1 1
MIRT681081 OGFRL1 opioid growth factor receptor-like 1 1 1
MIRT687539 MOB1B MOB kinase activator 1B 1 1
MIRT688952 ATXN3 ataxin 3 1 1
MIRT689014 ARSB arylsulfatase B 1 1
MIRT689525 ORC6 origin recognition complex, subunit 6 1 1
MIRT692912 EXOSC2 exosome component 2 1 1
MIRT695364 PHAX phosphorylated adaptor for RNA export 1 1
MIRT695643 NUP205 nucleoporin 205kDa 1 1
MIRT696064 ZNF264 zinc finger protein 264 1 1
MIRT696657 AGXT2 alanine--glyoxylate aminotransferase 2 1 1
MIRT696682 APOC3 apolipoprotein C-III 1 1
MIRT697184 QPCTL glutaminyl-peptide cyclotransferase-like 1 1
MIRT697301 ZNF652 zinc finger protein 652 1 1
MIRT697730 USP6NL USP6 N-terminal like 1 1
MIRT697868 UBE2D3 ubiquitin-conjugating enzyme E2D 3 1 1
MIRT697881 UBE2B ubiquitin-conjugating enzyme E2B 1 1
MIRT698074 TRIM45 tripartite motif containing 45 1 1
MIRT700147 RNF115 ring finger protein 115 1 1
MIRT700910 PDXK pyridoxal (pyridoxine, vitamin B6) kinase 1 1
MIRT701091 PAPOLG poly(A) polymerase gamma 1 1
MIRT701189 OTUD3 OTU domain containing 3 1 1
MIRT701852 MRO maestro 1 1
MIRT702078 PCDHB11 protocadherin beta 11 1 1
MIRT702605 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 1 1
MIRT703302 GGCX gamma-glutamyl carboxylase 1 1
MIRT704317 DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) 1 1
MIRT704386 CTSS cathepsin S 1 1
MIRT704459 CRNKL1 crooked neck pre-mRNA splicing factor-like 1 (Drosophila) 1 1
MIRT704634 CLCC1 chloride channel CLIC-like 1 1 1
MIRT705569 ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 1 1
MIRT705871 AEN apoptosis enhancing nuclease 1 1
MIRT711313 IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1 1
MIRT716815 FGG fibrinogen gamma chain 1 1
MIRT718897 SLFN5 schlafen family member 5 1 1
MIRT722886 MOB3A MOB kinase activator 3A 1 1
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